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N-Cbz-Nortropinone

N-Cbz-Nortropinone structure

CAS No.: 130753-13-8

Chemical Name:: N-Cbz-Nortropinone

Synonyms: N-Cbz-tropine;N-Cbz-Notropinone;N-CBZ-NORTROPINONE;N-Cbz-4-Nortropinone;N-Cbz-nortropinone ,97%;8-Cbz-3-oxo-8-azabicyclo[3.2.1]octane;Benzyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;benzyl (1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;(1S)-BENZYL 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE;Benzyl (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate

CBNumber:: CB6171135

Molecular Formula:: C15H17NO3

Molecular Weight:: 259.3

MDL Number:: MFCD14279161

MOL File:: 130753-13-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:22:33

Product description	Number	Pack Size	Price
N-Z-4-Nortropinone	240139	1g	$186
N-Z-4-Nortropinone	240139	5g	$273
N-Z-4-Nortropinone	240139	25g	$778
N-CBZ-NORTROPINONE 95%	57130	5G	$31
N-CBZ-NORTROPINONE 95%	57130	25G	$79
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N-Cbz-Nortropinone Properties

Boiling point	415.7±45.0 °C(Predicted)
Density	1.241±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	-1.70±0.20(Predicted)
color	white crystalline powder
InChI	InChI=1S/C15H17NO3/c17-14-8-12-6-7-13(9-14)16(12)15(18)19-10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2
InChIKey	RMIQGRJJCNFRRU-UHFFFAOYSA-N
SMILES	C12N(C(OCC3=CC=CC=C3)=O)C(CC1)CC(=O)C2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H227
Precautionary statements	P501-P261-P270-P210-P271-P264-P280-P370+P378-P362+P364-P301+P312+P330-P302+P352+P312-P304+P340+P312-P403+P235

N-Cbz-Nortropinone price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	240139	N-Z-4-Nortropinone	130753-13-8	1g	$186	2026-06-03	Buy
Usbiological	240139	N-Z-4-Nortropinone	130753-13-8	5g	$273	2026-06-03	Buy
Usbiological	240139	N-Z-4-Nortropinone	130753-13-8	25g	$778	2026-06-03	Buy
AstaTech	57130	N-CBZ-NORTROPINONE 95%	130753-13-8	5G	$31	2026-04-30	Buy
AstaTech	57130	N-CBZ-NORTROPINONE 95%	130753-13-8	25G	$79	2026-04-30	Buy

Product number	Packaging	Price	Buy
240139	1g	$186	Buy
240139	5g	$273	Buy
240139	25g	$778	Buy
57130	5G	$31	Buy
57130	25G	$79	Buy

N-Cbz-Nortropinone Chemical Properties,Uses,Production

Synthesis

25602-68-0

501-53-1

130753-13-8

1. 8-Azabicyclo[3,2,1]octan-3-one hydrochloride (10.0 g; 71.84 mmol) was dissolved in dichloroethane (DCE, 60 mL), and 1-chloroethyl chloroformate (ACE-C1, 14.5 mL; 19.11 g; 133.7 mmol) was added slowly and dropwise. The reaction mixture was stirred overnight at room temperature, then diluted with ether (Et2O, 400 mL) and filtered. The filtrate was concentrated under reduced pressure to give crude chloroethyl carbamate. 2. The above crude product was dissolved in methanol (MeOH, 200 mL) and stirred at room temperature for 1 h. Subsequently, it was concentrated under reduced pressure at 55 °C to obtain crude desmethyltropinone hydrochloride (brown solid, 11.4 g, 98% yield). 3. The crude product was purified by recrystallization from formonitrile to give a white crystalline solid (5 g, 43% yield).1H NMR (400 MHz, DMSO-d6) δ 1.79 (dd, J = 15.0,6.9 Hz, 2H), 2.09 (m, 2H), 2.40 (d, J = 16.7 Hz, 2H), 3.02 (dd, J = 17.1,4.3 Hz, 2H), 4.23 (s, 2H), 10.00 (br s, 2H). 4. desmethyltropinone (5.10 g; 31.55 mmol) was dissolved in dichloromethane (CH2Cl2, 50 mL) and benzyl chloroformate (4.29 mL; 5.11 g; 29.98 mmol) and diisopropylethylamine (DIPEA, 16.48 mL; 12.23 g; 94.66 mmol) were added slowly and dropwise (note exothermic reaction). The reaction mixture was stirred at room temperature for 30 min and then diluted with dichloromethane (100 mL). 5. The organic phase was washed with 1N hydrochloric acid (2 x 100 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give the crude product (7.2 g, 88% yield).1H NMR (400 MHz, CDCl3) δ 1.71 (dd, J = 15.0,7.2Hz, 2H), 2.12 (m, 2H), 2.38 (d, J = 15.9 Hz, 2H), 2.67 (m, 2H), 4.62 (s, 2H), 5.22 (s, 2H), 7.38 (m, 5H).

References

[1] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 84
[2] Patent: JP2015/124178, 2015, A. Location in patent: Paragraph 0143
[3] Patent: WO2004/100946, 2004, A1. Location in patent: Page 77
[4] Patent: WO2006/58303, 2006, A2. Location in patent: Page/Page column 71
[5] Patent: WO2010/126163, 2010, A1. Location in patent: Page/Page column 38-39

N-Cbz-Nortropinone synthesis

Synthesis of N-Cbz-Nortropinone from Nortropinone hydrochloride and Benzyl chloroformate

N-Cbz-Nortropinone Preparation Products And Raw materials

Raw materials

Nortropinone hydrochloride Tropinone N,N-Diisopropylethylamine Dichloromethane Nortropan-3-one

Benzyl chloroformate

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Preparation Products

N-Cbz-Nortropinone Suppliers

Global( 127)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific		tp@aladdinsci.com	United States	50108	58
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5838	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21135	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58

Supplier	Advantage
Aladdin Scientific	58
Hebei Yanxi Chemical Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from N-Cbz-Nortropinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-20	N-Cbz-Nortropinone 130753-13-8		1kg	0.99	20tons	Hebei Yanxi Chemical Co., Ltd.
2024-04-02	N-Cbz-Nortropinone 130753-13-8	$10.00-100.00	1kg	99%	5000 Metric Ton/Month	Wuhan Xinhao Biotechnology Co., Ltd
2023-04-12	N-Cbz-Nortropinone 130753-13-8	$1.00	1Kg/Bag	99.70% HPLC	100tons	Wuhan Dujiang Industrial Co., Ltd.

N-Cbz-Nortropinone
130753-13-8
$0.00
0.99
Hebei Yanxi Chemical Co., Ltd.

N-Cbz-Nortropinone
130753-13-8
$10.00-100.00
99%
Wuhan Xinhao Biotechnology Co., Ltd

N-Cbz-Nortropinone
130753-13-8
$1.00
99.70% HPLC
Wuhan Dujiang Industrial Co., Ltd.

N-Cbz-Nortropinone Spectrum

N-Cbz-Nortropinone(130753-13-8)¹HNMR

130753-13-8(N-Cbz-Nortropinone)Related Search:

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Tosyl-L-Phenylalanine chloromethylketone Benzyl N-Carbethoxy-4-tropinone

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N-Cbz-nortropinone ,97% N-Cbz-4-Nortropinone 8-Cbz-3-oxo-8-azabicyclo[3.2.1]octane Benzyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate N-Cbz-Notropinone benzyl (1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-oxo-, phenylmethyl ester Benzyl (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate (1R)-tert-Butyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate N-CBZ-NORTROPINONE N-Cbz-tropine (1S)-BENZYL 3-OXO-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE 3-Oxo-8-azabicyclo[3.2.1]octane-8-carboxylic acid benzyl ester rac-benzyl (1r,5s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 130753-13-8 pharmacetical Heterocycle