(S)-1-Boc-3-(aminomethyl)pyrrolidine
- CAS No.
- 199175-10-5
- Chemical Name:
- (S)-1-Boc-3-(aminomethyl)pyrrolidine
- Synonyms
- tert-butyl (S)-3-(aminomethyl)pyrrolidine-1-carboxylate;(S)-1-Boc-3-(aminomethyl)...;S-1-N-Boc-3-aMinoMethypyrrolidine;(S)-1-Boc-3-aminomethylpyrolidine;(S)-1-BOC-3-AMINOMETHYLPYRROLIDINE;(S)-N-BOC-3-(AMINOMETHYL)PYRROLIDINE;(3S)-3-Aminomethyl-1-Boc-pyrrolidine;(S)-3-(Aminomethyl)-1-Boc-pyrrolidine;(S)-1-N-BOC-3-(AMINOMETHYL)PYRROLIDINE;(S)-3-(AMINOMETHYL)-1-N-BOC-PYRROLIDINE
- CBNumber:
- CB6220253
- Molecular Formula:
- C10H20N2O2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD02179397
- MOL File:
- 199175-10-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 280.3±13.0 °C(Predicted) |
|---|---|
| Density | 1.044±0.06 g/cm3(Predicted) |
| refractive index | 1.4780 |
| storage temp. | 2-8°C |
| pka | 10.12±0.29(Predicted) |
| form | Liquid |
| color | Colorless to yellow |
| optical activity | Consistent with structure |
| Sensitive | Air Sensitive |
| InChI | 1S/C10H20N2O2/c1-10(2,3)14-9(13)12-5-4-8(6-11)7-12/h8H,4-7,11H2,1-3H3/t8-/m0/s1 |
| InChIKey | OGCCBDIYOAFOGK-QMMMGPOBSA-N |
| SMILES | CC(C)(C)OC(=O)N1CC[C@@H](CN)C1 |
| CAS DataBase Reference | 199175-10-5(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
(S)-1-Boc-3-(aminomethyl)pyrrolidine price More Price(79)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 689823 | (S)-3-(Aminomethyl)-1-Boc-pyrrolidine 95% | 199175-10-5 | 100mg | $61 | 2023-06-20 | Buy |
| Sigma-Aldrich | 689823 | (S)-3-(Aminomethyl)-1-Boc-pyrrolidine 95% | 199175-10-5 | 500mg | $252 | 2023-06-20 | Buy |
| Usbiological | 263920 | S-1-N-Boc-3-(aminomethyl)pyrrolidine Asreported | 199175-10-5 | 250mg | $360 | 2026-06-03 | Buy |
| Usbiological | 263920 | S-1-N-Boc-3-(aminomethyl)pyrrolidine Asreported | 199175-10-5 | 500mg | $509 | 2026-06-03 | Buy |
| Usbiological | 263920 | S-1-N-Boc-3-(aminomethyl)pyrrolidine Asreported | 199175-10-5 | 1g | $686 | 2026-06-03 | Buy |
(S)-1-Boc-3-(aminomethyl)pyrrolidine Chemical Properties, Uses, Production
Uses
(S)-1-Boc-3-(Aminomethyl)pyrrolidine is a useful research chemical for organic synthesis and other chemical processes.It is used in preparation of isoquinoline derivatives as progranulin modulators useful in treatment of progranulin- associated disorders.
Synthesis
132945-76-7
199175-10-5
c) Synthesis of 1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidine carboxylate 1,1-Dimethylethyl (3R)-3-cyano-1-pyrrolidine carboxylate (73.9 mmol) was dissolved in ethanol (100 mL) in a Parr bottle. Raney Nickel (73.9 mmol; about 2 scoops of aqueous Raney Nickel) was added under nitrogen protection. After sufficiently displacing the air in the reaction system with nitrogen, the reaction mixture was placed on a Parr shaker at 60 psi hydrogen pressure overnight. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth under nitrogen protection and the filter cake was washed with a small amount of ethanol. Subsequently, the filter cake was immediately treated with water. The ethanol filtrate was concentrated under reduced pressure to give the title product as a clear oil (71.9 mmol, 97% yield). The enantiomeric ratio of the product was determined to be 95:5 (i.e. >90% ee). The product was analyzed by chiral HPLC (Daicel Chiralpak AD-H column, 4.6 x 150 mm; mobile phase: heptane:ethanol:isopropylamine=85:10:0.1; flow rate: 1.0 mL/min; UV detection wavelength: 215 nm), and the retention of 1,1-dimethylethyl (3R)-3-(aminomethyl)-1-pyrrolidinecarboxylate time was 4.4 min, and the retention time of 1,1-dimethylethyl (3S)-3-(aminomethyl)-1-pyrrolidine carboxylate was 4.8 min. 1H NMR (400 MHz, CDCl3) δ ppm: 1.47 (s, 9H), 1.54-1.73 (m, 1H), 1.91-2.13 (m, 1H), 2.28-2.52 (m, 1H), 2.78-2.93 (m, 1H), 2.95-3.16 (m, 1H), 3.24-3.67 (m, 5H) .
References
[1] Patent: WO2011/56635, 2011, A1. Location in patent: Page/Page column 50
[2] Patent: WO2011/66211, 2011, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2013/28445, 2013, A1. Location in patent: Page/Page column 51; 52
[4] Patent: WO2012/37298, 2012, A1. Location in patent: Page/Page column 83
(S)-1-Boc-3-(aminomethyl)pyrrolidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from (S)-1-Boc-3-(aminomethyl)pyrrolidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | (S)-1-Boc-3-(aminomethyl)pyrrolidine
199175-10-5
|
$1.00 | 1KG | 95% | 200KG | Career Henan Chemical Co |
-
- (S)-1-Boc-3-(aminomethyl)pyrrolidine
199175-10-5
- $1.00
- 95%
- Career Henan Chemical Co
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