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ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate structure

CAS No.: 238749-50-3

Chemical Name:: ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

Synonyms: ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate;Ethyl2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate,95%;2-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-, ethyl e...;4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-, ethyl ester

CBNumber:: CB62525503

Molecular Formula:: C9H8BrNO2S

Molecular Weight:: 274.14

MDL Number:: MFCD15730638

MOL File:: 238749-50-3.mol

MSDS File:: SDS

Last updated:2026-05-28 02:56:57

Product description	Number	Pack Size	Price
Ethyl 2-bromo-4H-thieno-[3,2-b]pyrrole-5-carboxylate	144105	1.00g	$916
Ethyl 2-bromo-4H-thieno-[3,2-b]pyrrole-5-carboxylate	144105	5.00g	$1841
Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate >98%	E69587	250mg	$61
Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate >98%	E69587	1g	$90
Ethyl 2-Bromo-4H-Thieno[3,2-B]Pyrrole-5-Carboxylate 95%(stabilizedwithCu+HQ+MgO)	AA00BG11	100mg	$17

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ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Properties

Boiling point	398.8±37.0 °C(Predicted)
Density	1.692±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	13.72±0.30(Predicted)
Appearance	Light yellow to yellow Solid
Water Solubility	Sparingly soluble in water.
InChI	InChI=1S/C9H8BrNO2S/c1-2-13-9(12)6-3-7-5(11-6)4-8(10)14-7/h3-4,11H,2H2,1H3
InChIKey	KXGSKTSSCQBDOA-UHFFFAOYSA-N
SMILES	N1C(C(OCC)=O)=CC2SC(Br)=CC1=2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

NFPA 704

	1
2		0

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	144105	Ethyl 2-bromo-4H-thieno-[3,2-b]pyrrole-5-carboxylate	238749-50-3	1.00g	$916	2026-05-18	Buy
Matrix Scientific	144105	Ethyl 2-bromo-4H-thieno-[3,2-b]pyrrole-5-carboxylate	238749-50-3	5.00g	$1841	2026-05-18	Buy
Synthonix	E69587	Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate >98%	238749-50-3	250mg	$61	2026-05-06	Buy
Synthonix	E69587	Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate >98%	238749-50-3	1g	$90	2026-05-06	Buy
aablocks	AA00BG11	Ethyl 2-Bromo-4H-Thieno[3,2-B]Pyrrole-5-Carboxylate 95%(stabilizedwithCu+HQ+MgO)	238749-50-3	100mg	$17	2026-05-28	Buy

Product number	Packaging	Price	Buy
144105	1.00g	$916	Buy
144105	5.00g	$1841	Buy
E69587	250mg	$61	Buy
E69587	1g	$90	Buy
AA00BG11	100mg	$17	Buy

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate is used as an important raw material in organic synthesis.

Synthesis

4701-17-1

637-81-0

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate

238749-50-3

Under argon protection, 5-bromo-2-thiophenecarboxaldehyde (19.1 g, 0.1 mol) and ethyl azidoacetate (51.6 g, 0.4 mol) were dissolved in anhydrous ethanol (800 mL) in a 2 L four-necked flask and the air in the reaction system was displaced by a stream of argon gas. An ethanolic solution of sodium mass ethanolate (136 g, 0.4 mol) was slowly added dropwise to the above mixed solution under the condition of cooling to 0 °C in an ice bath, followed by stirring the reaction for 2 hours at 0 °C. After completion of the reaction, saturated aqueous ammonium chloride solution was added to adjust the reaction solution to weak acidity (pH ≈ 6). Then, appropriate amount of water was added to dilute the reaction mixture, and the precipitate precipitated was collected by filtration and dried to obtain ethyl 2-azido-3-(5-bromo-2-thienyl)-acrylate as a yellow solid (yield: 18.4 g, yield: 61.3%). Next, ethyl 2-azido-3-(5-bromo-2-thienyl)-acrylate (18.1 g, 60 mmol) was transferred to a 500 mL aubergine flask, dissolved in o-xylene (200 mL), heated to reflux and stirred for 1.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure and the resulting crude product was purified by recrystallization (solvent: hexane/ethyl acetate mixture). The crystalline product was collected by filtration and dried to give ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate (d-1) (Yield: 12.1 g, Yield: 73.8%).

References

[1] Patent: US2015/158888, 2015, A1. Location in patent: Paragraph 0075-0080
[2] Chemistry - An Asian Journal, 2015, vol. 10, # 6, p. 1335 - 1343
[3] Patent: US2016/271273, 2016, A1. Location in patent: Paragraph 0289

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Preparation Products And Raw materials

Raw materials

5-Bromothiophene-2-carbaldehyde Ethyl Azidoacetate o-Xylene Ethanol Sodium ethoxide

Preparation Products

ethyl 2-broMo-6-forMyl-4H-thieno[3,2-b]pyrrole-5-carboxylate

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Suppliers

Global( 65)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25333	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9976	58
Golden Pharma Co., Limited	+86-18958062155	sales@zjgoldpharm.com	China	5893	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18114	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	China	8433	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Suzhou Chukai Pharma Tech Co.,Ltd	+86-15151706780; +86-15062531973	2279973922@qq.com	China	404	58
Aladdin Scientific		tp@aladdinsci.com	United States	50110	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Coresyn Pharmatech Co., Ltd.	58
Golden Pharma Co., Limited	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Suzhou Chukai Pharma Tech Co.,Ltd	58
Aladdin Scientific	58

View Lastest Price from ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate 238749-50-3	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate
238749-50-3
$9.80
≥99%
Career Henan Chemical Co

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Spectrum

ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate(238749-50-3)¹HNMR

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2-Bromo-4H-thieno[3,2-b]pyrrole-5-carboxylic acid ethyl ester 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-, ethyl ester ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Ethyl2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate,95% 4H-Thieno[3,2-b]pyrrole-5-carboxylic acid, 2-bromo-, ethyl e... 238749-50-3