N-Me-Aib-OH HCl
- CAS No.
- 2566-34-9
- Chemical Name:
- N-Me-Aib-OH HCl
- Synonyms
- MeAIB;2-(METHYLAMINO)ISOBUTYRIC ACID;N-ME-AIB-OH;H-MEAIB-OH;H-N-Me-Aib-OH;H-(ME)MEALA-OH;N-Me-Aib-OH HCl;N-Me-a-Me-Ala-OH;2,N-DIMETHYLALANINE;N,2-DIMETHYLALANINE
- CBNumber:
- CB6316473
- Molecular Formula:
- C5H11NO2
- Molecular Weight:
- 117.15
- MDL Number:
- MFCD00004191
- MOL File:
- 2566-34-9.mol
- MSDS File:
- SDS
| Melting point | 300 °C |
|---|---|
| Boiling point | 192.5±23.0 °C(Predicted) |
| Density | 1.2000 (estimate) |
| refractive index | 1.4650 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| Water Solubility | almost transparency in Water |
| pka | 2.17±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 1746984 |
| InChI | 1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8) |
| InChIKey | DLAMVQGYEVKIRE-UHFFFAOYSA-N |
| SMILES | CNC(C)(C)C(O)=O |
| FDA UNII | 26F96C8MBJ |
| UNSPSC Code | 12352209 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2922.49.8000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
N-Me-Aib-OH HCl price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M2383 | α-(Methylamino)isobutyric acid ≥97% (titration) | 2566-34-9 | 250mg | $60.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | M2383 | α-(Methylamino)isobutyric acid ≥97% (titration) | 2566-34-9 | 1g | $171 | 2026-04-30 | Buy |
| TCI Chemical | M1388 | 2-(Methylamino)isobutyric Acid Hydrate >98.0%(T) | 2566-34-9 | 1g | $65 | 2026-04-30 | Buy |
| TCI Chemical | M1388 | 2-(Methylamino)isobutyric Acid Hydrate >98.0%(T) | 2566-34-9 | 5g | $192 | 2026-04-30 | Buy |
| Usbiological | 217135 | a-(Methylamino)isobutyric Acid (Neutral Amino Acid Transporter A Inhibitor, MeBIA) ≥98%(TLC) | 2566-34-9 | 250mg | $453 | 2026-06-03 | Buy |
N-Me-Aib-OH HCl Chemical Properties, Uses, Production
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
α-(Methylamino)isobutyric acid (MeAIB) has been used:
- as a system A transport system inhibitor to perform inhibition experiments
- as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
- as an N-acetyltransferase (SNAT) inhibitor in Hankμs balanced salt solution (HBSS) to study its influence on the uptake of 14C-cysteine/ radioactive-labeled cysteine
Definition
ChEBI: Alpha-(methylamino)isobutyric acid is a non-proteinogenic alpha-amino acid that is isobutyric acid in which the alpha-hydrogen has been replaced by a methylamino group. It has a role as a human urinary metabolite. It is an alanine derivative, a non-proteinogenic alpha-amino acid and a secondary amino compound. It is functionally related to an isobutyric acid. It is a conjugate acid of a N-methyl-aminoisobutyrate zwitterion.
Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 8120, 1995 DOI: 10.1021/jo00130a002
Biological Activity
α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.
N-Me-Aib-OH HCl Preparation Products And Raw materials
Raw materials
Preparation Products
N-Me-Aib-OH HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| ChemPep, Inc. | +1 (888) 615-9178 / (561) 791-8787 | service@chempep.com | United States | 2138 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
