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4-Amino-3-nitropyridine

4-Amino-3-nitropyridine Structure
4-Amino-3-nitropyridine structure
CAS No.
1681-37-4
Chemical Name:
4-Amino-3-nitropyridine
Synonyms
3-NITROPYRIDIN-4-AMINE;3-NITRO-4-AMINOPYRIDINE;TIMTEC-BB SBB005533;3-Nitropyridin-4-amin;3-NITRO-4-PYRIDINAMINE;4-aMine-3-nitropyridine;4-AMINO-3-NITROPYRIDINE;4-Pyridinamine, 3-nitro-;(3-nitro-4-pyridyl)amine;3-NITRO-PYRIDIN-4-YLAMINE
CBNumber:
CB6398486
Molecular Formula:
C5H5N3O2
Molecular Weight:
139.11
MDL Number:
MFCD00160304
MOL File:
1681-37-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:03:30
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4-Amino-3-nitropyridine Properties

Melting point 203-207 °C (lit.)
Boiling point 255.04°C (rough estimate)
Density 1.4551 (rough estimate)
refractive index 1.5900 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form Crystalline Powder
pka 5.02±0.12(Predicted)
color Yellow
Water Solubility Insoluble in water.
BRN 383710
InChI InChI=1S/C5H5N3O2/c6-4-1-2-7-3-5(4)8(9)10/h1-3H,(H2,6,7)
InChIKey IUPPEELMBOPLDJ-UHFFFAOYSA-N
SMILES C1=NC=CC(N)=C1[N+]([O-])=O
CAS DataBase Reference 1681-37-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38-20/21/22
Safety Statements  26-36-36/37/39
RIDADR  UN2811
WGK Germany  3
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Amino-3-nitropyridine price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 646962 4-Amino-3-nitropyridine 97% 1681-37-4 10g $300 2026-04-30 Buy
Sigma-Aldrich 646962 4-Amino-3-nitropyridine 97% 1681-37-4 1g $39.4 2023-06-20 Buy
TCI Chemical A2260 4-Amino-3-nitropyridine >98.0%(GC)(T) 1681-37-4 5g $65 2026-04-30 Buy
TCI Chemical A2260 4-Amino-3-nitropyridine >98.0%(GC)(T) 1681-37-4 25g $257 2026-04-30 Buy
Usbiological 232790 4-Amino-3-nitropyridine 98+% ≥98% 5g $163 2026-06-03 Buy
Product number Packaging Price Buy
646962 10g $300 Buy
646962 1g $39.4 Buy
A2260 5g $65 Buy
A2260 25g $257 Buy
232790 5g $163 Buy

4-Amino-3-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

4-Amino-3-nitropyridine is used as a pharmaceutical intermediate.

Synthesis

4-Aminopyridine

504-24-5

4-Amino-3-nitropyridine

1681-37-4

The general procedure for the synthesis of 4-amino-3-nitropyridine from 4-aminopyridine was as follows: pyridin-4-amine (5.0 g, 50.0 mmol) was dissolved in concentrated sulfuric acid (20 mL) under ice-bath conditions. Keeping the reaction temperature in the range of 0-10 °C, fuming nitric acid (2.5 mL) was added slowly and dropwise. After the dropwise addition, the reaction was continued to be stirred at 0-10 °C for 5 hours. Subsequently, the reaction mixture was warmed to room temperature and heated at 90°C for 3 hours. After the reaction was completed, the mixture was continued to be stirred at room temperature overnight. The reaction mixture was slowly poured into ice water and the pH was adjusted with ammonia to 7. The resulting precipitate was collected by filtration and dried under reduced pressure to afford 4-amino-3-nitropyridine as a yellow solid (5.1 g, 70% yield). Mass spectrometry analysis showed [M + H]+ m/z: 140.04.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2621 - 2631
[2] Synthesis, 2011, # 5, p. 794 - 806
[3] Chemistry of Heterocyclic Compounds, 2015, vol. 51, # 2, p. 203 - 204
[4] Khim. Geterotsikl. Soedin., 2015, vol. 51, # 2, p. 203 - 204,2
[5] Patent: WO2017/168333, 2017, A1. Location in patent: Page/Page column 16

4-Amino-3-nitropyridine synthesis

1796-84-5
1681-37-4
Synthesis of 4-Amino-3-nitropyridine from 4-Ethoxy-3-nitropyridine

4-Amino-3-nitropyridine Preparation Products And Raw materials

Raw materials

N-Nitropyridin-4-amine 4-Chloro-3-nitro-2,6-pyridinediamine Ammonium hydroxide 4-Aminopyridine 2-Amino-4-chloro-3-nitropyridine
4-Ethoxy-3-nitropyridine hydrochloride 4-Acetamidopyridine 4-Ethoxy-3-nitropyridine 2-Amino-4-chloro-5-nitropyridine

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Preparation Products

2-Chloro-pyridine-3,4-diamine 2-Chloro-3,4-diaminopyridine 4-Acetamido-3-aminopyridine 2-Methylimidazo[4,5-c]pyridine 3,4-Diaminopyridine
4-Acetamido-3-nitropyridine 5-Azabenzimidazole AMifaMpridine Phosphate

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4-Amino-3-nitropyridine Suppliers

Global( 398)Suppliers
Supplier Tel Email Country ProdList Advantage
Nan Jing Dirise Chemcial Co.,LTD 025-52161033 15312098939 2432674894@qq.com China 584 64
Shandong Meiao Huawei Technology Co., LTD 0531-88682301 18595278766 yuhongmeng@mayowell.com China 88 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Supplier Advantage
Nan Jing Dirise Chemcial Co.,LTD 64
Shandong Meiao Huawei Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
future industrial shanghai co., ltd 65
Chembest Research Laboratories Limited 61
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Ark Pharm, Inc. 56

View Lastest Price from 4-Amino-3-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Amino-3-nitropyridine pictures 2026-08-20 4-Amino-3-nitropyridine
1681-37-4
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
4-Amino-3-nitropyridine pictures 2025-04-04 4-Amino-3-nitropyridine
1681-37-4
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
4-Amino-3-nitropyridine pictures 2021-07-13 4-Amino-3-nitropyridine
1681-37-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4-Amino-3-nitropyridine Spectrum

4-Amino-3-nitropyridine(1681-37-4)1HNMR

1681-37-4(4-Amino-3-nitropyridine)Related Search:

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4-aMine-3-nitropyridine 4-Amino-3-nitropyridine,96% (3-nitro-4-pyridyl)amine 4-Pyridinamine, 3-nitro- TIMTEC-BB SBB005533 3-NITRO-4-PYRIDINAMINE 4-AMINO-3-NITROPYRIDINE 3-NITRO-PYRIDIN-4-YLAMINE 4-AMino-3-nitropyridine, 98% 1GR 4-Amino-3-nitropyridine ,98% 4-Amino-3-nitropyridine > 4-Amino-3-nitropyridine ISO 9001：2015 REACH 3-Nitropyridin-4-amin 3-NITROPYRIDIN-4-AMINE 3-NITRO-4-AMINOPYRIDINE 1681-37-4 C5 Building Blocks Heterocyclic Building Blocks Pyridines Pyridines Boronic Acid C5 Heterocyclic Building Blocks Building Blocks/Intermediates Pyridine Series Pyridines derivates Pyridine