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2-Amino-4-chloro-5-nitropyridine

2-Amino-4-chloro-5-nitropyridine Structure
2-Amino-4-chloro-5-nitropyridine structure
CAS No.
24484-96-6
Chemical Name:
2-Amino-4-chloro-5-nitropyridine
Synonyms
2-AMino-4-chloro-5-nitrop...;4-Chloro-5-nitro-2-pyridinaMine;4-Chloro-5-nitropyridine-2-aMine;6-Amino-4-chloro-3-nitropyridine;2-Amino-4-chloro-5-nitropyridine;2-Amino-5-nitro-4-chloropyridine;2-Pyridinamine, 4-chloro-5-nitro-;4-CHLORO-5-NITRO-PYRIDIN-2-YLAMINE;2-Amino-4-chloro-5-nitropyridine 96%;2-AMINO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber:
CB2132006
Molecular Formula:
C5H4ClN3O2
Molecular Weight:
173.56
MDL Number:
MFCD04973545
MOL File:
24484-96-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:50:13
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2-Amino-4-chloro-5-nitropyridine Properties

Melting point 240-242°C
Boiling point 377℃
Density 1.596
Flash point 182℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMF, DMSO, Hot Ethanol, Ethyl Acetate, Hot Methanol
form Solid
pka 1.77±0.24(Predicted)
color Brown
CAS DataBase Reference 24484-96-6

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2933399990

2-Amino-4-chloro-5-nitropyridine price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological A1376-53 2-Amino-4-chloro-5-nitropyridine 100mg $531 2026-06-03 Buy
TRC TRC-A603487-50MG 2-Amino-4-chloro-5-nitropyridine 24484-96-6 50mg $167 2026-06-03 Buy
TRC TRC-A603487-250MG 2-Amino-4-chloro-5-nitropyridine 24484-96-6 250mg $606 2026-06-03 Buy
TRC TRC-A603487-100MG 2-Amino-4-chloro-5-nitropyridine 24484-96-6 100mg $289 2026-06-03 Buy
AstaTech CL0268 2-AMINO-4-CHLORO-5-NITROPYRIDINE 97% 24484-96-6 1G $33 2026-04-30 Buy
Product number Packaging Price Buy
A1376-53 100mg $531 Buy
TRC-A603487-50MG 50mg $167 Buy
TRC-A603487-250MG 250mg $606 Buy
TRC-A603487-100MG 100mg $289 Buy
CL0268 1G $33 Buy

2-Amino-4-chloro-5-nitropyridine Chemical Properties, Uses, Production

Chemical Properties

Brown Solid

Synthesis

2-Amino-4-chloropyridine

19798-80-2

2-Amino-4-chloro-3-nitropyridine

6980-08-1

2-AMINO-4-CHLORO-5-NITROPYRIDINE

24484-96-6

Example 13 (a) Procedure for the synthesis of 4-chloro-3-nitropyridin-2-amine (Aust. J. Chem. 1982,35,2025.): 4-chloro-2-aminopyridine (10 g, 77.5 mmol) was dissolved in concentrated sulfuric acid (100 mL) and cooled to about -8°C using a salt-ice bath. Fuming nitric acid was added slowly with stirring, keeping the reaction temperature below 0°C. After addition, the reaction mixture was stirred at room temperature for 20 minutes, followed by careful pouring onto ice. A 32% ammonium hydroxide solution was slowly added while the temperature was controlled with an ice bath below 25 °C until the solution pH reached 3. The solid product was collected by filtration, washed with water and recrystallized from a 1:1 aqueous solution. The resulting solid was added to ice-cold concentrated sulfuric acid (200 mL) in batches, controlling the rate of addition to maintain the temperature below 4 °C. After addition, the reaction mixture was allowed to come to room temperature. After 2.5 hours of reaction, two regional isomers (1:1 ratio), 3-nitro and 5-nitro compounds, were detected by LCMS. The reaction mixture was poured into ice and alkalized with 32% ammonium hydroxide solution. It was filtered and washed with water to obtain a mixture of the two regional isomers. The mixture was dissolved in ethyl acetate and heptane was added to precipitate the unwanted regional isomer. The isomer is removed by filtration and the ethyl acetate is evaporated to give the target product and 15-20% of the impure isomer. In addition, the two isomers could be separated by rapid chromatography on silica gel (Combiflash system) and an appropriate ethyl acetate/heptane gradient. The final product was obtained as 5 g in 37% yield. m/z 172 (M-1) by MS (ESI), 174. 2.2 min RT (LCMS, 254 nm).

References

[1] Tetrahedron Letters, 2012, vol. 53, # 42, p. 5597 - 5601
[2] Patent: WO2007/40438, 2007, A2. Location in patent: Page/Page column 59
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734,14
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8721 - 8734
[5] Patent: WO2013/190320, 2013, A1. Location in patent: Paragraph 00117; 00118

2-Amino-4-chloro-5-nitropyridine Preparation Products And Raw materials

Raw materials

4-Chloro-3-nitropyridine 4-Chloro-2-nitroaminopyridine 2-Amino-4-chloropyridine Ammonia

Preparation Products

2-Amino-4-chloro-3-nitropyridine 4-Amino-3-nitropyridine 2,4-Dichloro-5-nitropyridine

2-Amino-4-chloro-5-nitropyridine Suppliers

Global Suppliers ( 165)
Supplier Tel Email Country ProdList Advantage
Suzhou bonei Biotechnology Co., Ltd 13812661976 info@szbiolight.com China 380 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Accela ChemBio Co.,Ltd. 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Supplier Advantage
Suzhou bonei Biotechnology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Liaoning Tianhua Chemical Co., Ltd. 69
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Capot Chemical Co., Ltd 66
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Jinan Trio PharmaTech Co., Ltd. 62

View Latest Price from 2-Amino-4-chloro-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4-CHLORO-5-NITROPYRIDINE pictures 2026-08-20 2-AMINO-4-CHLORO-5-NITROPYRIDINE
24484-96-6
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-AMINO-4-CHLORO-5-NITROPYRIDINE pictures 2019-12-23 2-AMINO-4-CHLORO-5-NITROPYRIDINE
24484-96-6
 $1.00 1g 99% 1000KGS Career Henan Chemical Co

2-Amino-4-chloro-5-nitropyridine Spectrum

2-AMINO-4-CHLORO-5-NITROPYRIDINE(24484-96-6)1HNMR

24484-96-6 (2-Amino-4-chloro-5-nitropyridine) Related Search:

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4-CHLORO-5-NITRO-PYRIDIN-2-YLAMINE 2-Pyridinamine, 4-chloro-5-nitro- 2-Amino-4-chloro-5-nitropyridine 96% 6-Amino-4-chloro-3-nitropyridine 4-Chloro-5-nitropyridine-2-aMine 4-Chloro-5-nitro-2-pyridinaMine 2-AMino-4-chloro-5-nitrop... 2-AMINO-4-CHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH 2-Amino-5-nitro-4-chloropyridine 2-Amino-4-chloro-5-nitropyridine 24484-96-6 24484-94-6 Amines Aromatics Heterocycles Miscellaneous Reagents Nucleotides and Nucleosides Bases & Related Reagents Nucleotides Pyridines Amino-pyridine series API intermediates