4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 158407-04-6
- Chemical Name:
- 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-Butyl 4-(bromomethyl)piperidine-1-carboxylate;4-BROMOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;CAS:158407-04-6;1-Boc-4-BromomethyL;1-Boc-4-broMoMethylpiperi...;1-BOC-4-BROMOMETHYLPIPERIDINE;N-BOC-4-BROMOMETHYL-PIPERIDINE;1-N-BOC-4-BROMOMETHYLPIPERIDINE;1-Boc-4-(bromoMmethyl)piperidine;4-Bromomethyl-1-(tert-butoxycarbonyl)piperidine
- CBNumber:
- CB6404026
- Molecular Formula:
- C11H20BrNO2
- Molecular Weight:
- 278.19
- MDL Number:
- MFCD04115538
- MOL File:
- 158407-04-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 318.3±15.0 °C(Predicted) |
|---|---|
| Density | 1.270±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | -1.91±0.40(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C11H20BrNO2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-8H2,1-3H3 |
| InChIKey | YGJXBTRLYHCWGD-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(CBr)CC1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
| Risk Statements | 36/37/38-36 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 796719 | 4-Bromomethyl-piperidine-1-carboxylic acid tert-butyl ester 95% | 158407-04-6 | 1g | $366 | 2026-04-30 | Buy |
| TCI Chemical | B6510 | tert-Butyl 4-(Bromomethyl)piperidine-1-carboxylate min. 98.0 % | 158407-04-6 | 1G | $35 | 2026-04-30 | Buy |
| TCI Chemical | B6510 | tert-Butyl 4-(Bromomethyl)piperidine-1-carboxylate min. 98.0 % | 158407-04-6 | 10G | $186 | 2026-04-30 | Buy |
| Usbiological | 265791 | 1-Boc-4-bromomethylpiperidine Asreported | 158407-04-6 | 500mg | $340 | 2026-06-03 | Buy |
| Usbiological | 265791 | 1-Boc-4-bromomethylpiperidine Asreported | 158407-04-6 | 1g | $562 | 2026-06-03 | Buy |
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Uses
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research and development process and chemical production process.
Synthesis
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester. 4-N-Boc-piperidine-methanol (200 mg, 0.93 mmol) was dissolved in diethyl ether (9 mL) and carbon tetrabromide (370 mg, 1.1 mmol) and PPh3 (292 mg, 1.1 mmol) were added at rt. The reaction was allowed to stir for 18 h at rt and filtered over a pad of celite. The filtrate was concentrated and purified by flash chromatography (hexane/EtOAc, 1:0 ú 4:1) to give the title compound. Yield 55 mg. 1 (400 MHz, DMSO-d6) | ppm 4.02-3.98 (m, 2 H), 3.47 (d, 2 H), 2.78-2.65 (m, 2 H), 1.89-1.74 (m, 3 H), 1.45 (s, 9 H), 1.12-0.98 (m, 2 H).
References
[1] Patent: WO2016/75661, 2016, A1. Location in patent: Page/Page column 30
[2] Patent: WO2006/50506, 2006, A1. Location in patent: Page/Page column 120-121
[3] RSC Advances, 2016, vol. 6, # 52, p. 46170 - 46185
[4] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00266
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 17, p. 2615 - 2620
4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Bewellunion Pharmaceutical Co., Ltd. | 18601958187 | 247340078@qq.com | China | 144 | 58 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Ningbo Zeyu Chemical Technology Co., Ltd | 15066123231 | 2278736577@qq.com | China | 493 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 4-Bromomethypiperidine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-BROMOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
158407-04-6
|
$1.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-BROMOMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
158407-04-6
- $1.00
- 98%
- Career Henan Chemical Co
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