5-Bromopyridine-3-boronic acid
- CAS No.
- 452972-09-7
- Chemical Name:
- 5-Bromopyridine-3-boronic acid
- Synonyms
- 3-BROMOPYRIDINE-5-BORONIC ACID;AKOS BRN-0472;3-Bromopyridine-5-Boronic;3-BROMOPYRIDIN-5-BORONICACID;5-Bromopyridine-3-boronicaci;3-BROMOPYRIDYL-5-BORONIC ACID;3-BROMO-5-PYRIDYLBORONIC ACID;5-BROMOPYRIDINE-3-BORONIC ACID;3-BROMO-5-PYRIDINEBORONIC ACID;5-BROMO-3-PYRIDINEBORONIC ACID
- CBNumber:
- CB6433806
- Molecular Formula:
- C5H5BBrNO2
- Molecular Weight:
- 201.81
- MDL Number:
- MFCD02685634
- MOL File:
- 452972-09-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300°C |
|---|---|
| Boiling point | 351.5±52.0 °C(Predicted) |
| Density | 1.78±0.1 g/cm3(Predicted) |
| storage temp. | Keep Cold |
| pka | 5.91±0.10(Predicted) |
| form | solid |
| color | off white |
| BRN | 9119873 |
| CAS DataBase Reference | 452972-09-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
5-Bromopyridine-3-boronic acid price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 263799 | 5-Bromopyridine-3-boronic acid Asreported | 452972-09-7 | 1g | $329 | 2026-06-03 | Buy |
| Usbiological | 263799 | 5-Bromopyridine-3-boronic acid Asreported | 452972-09-7 | 2g | $468 | 2026-06-03 | Buy |
| Usbiological | 263799 | 5-Bromopyridine-3-boronic acid Asreported | 452972-09-7 | 5g | $686 | 2026-06-03 | Buy |
| Usbiological | 263799 | 5-Bromopyridine-3-boronic acid Asreported | 452972-09-7 | 10g | $907 | 2026-06-03 | Buy |
| Usbiological | 263799 | 5-Bromopyridine-3-boronic acid Asreported | 452972-09-7 | 25g | $1460 | 2026-06-03 | Buy |
5-Bromopyridine-3-boronic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powde
Uses
Reactant for preparation of:• ;Thienylpyridyl garlands via cross-coupling with heteroaryl halides1• ;Arenes via nickel-catalyzed cross-coupling with potassium aryl- and heteroaryl trifluoroborates2• ;Meso-substituted ABCD-type porphyrins by functionalization reactions3• ;Analogs of (acetylamino)(dimethylpyrazol)(pyridyl)pyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson′s disease4• ;5-hydroxy-1,3,2-dioxaborolan-4-ones boronate-amine complexes via heterocyclization with α-oxocarboxylic acids followed by subsequent complexation5&
Synthesis
407-20-5
452972-09-7
Steps for the synthesis of 3-bromo-5-pyridineboronic acid (2b): 3-bromo-5-fluoropyridine (2a) (25 kg, 142 moles, 1.0 eq.), THF (222.5 kg), and isopropyl borate (28 kg, 149.3 moles, 1.05 eq.) were added to a 700 L cryoreactor. The mixture was cooled to -90°C to -80°C and stirred. Subsequently, n-BuLi (40.2 kg, 2.5 M, 142 mol, 1.0 eq.) was added dropwise at a rate of 2 kg/h while ensuring that the temperature was below -87°C. After the dropwise addition, stirring of the reaction mixture was continued for 2.5 h at -88 °C to -83 °C. After confirming the completion of the reaction by HPLC analysis, the reaction was quenched by the addition of 9% HCl aqueous solution (7.7 kg). The mixture was transferred to a 1000 L glass-lined reactor and warmed to -20°C to -10°C. Next, additional HCl solution (122.3 kg) was added to adjust the pH to 1-2, during which the temperature was maintained at 0-10°C. It was allowed to stand for 0.5 h to stratify, the organic layer was separated and washed with saturated brine (38 kg). After stirring again for 0.5 h, the mixture was left to stratify for 0.5 h. The aqueous layer was separated. The aqueous layer was separated and the combined aqueous layers were extracted twice with EtOAc (51kg and 25kg). The organic phases were combined and the pH was adjusted to 6 with 30% NaOH aqueous solution (27.4 kg), at which point solids precipitated. The slurry was filtered by centrifugation and the solids were dried in a disk drier at 40-45 °C to give 3-bromo-5-pyridineboronic acid (2b) as a white solid (17.5 kg, 87.4% yield, 98.6% purity AUC, method of use B).
References
[1] Patent: WO2009/76200, 2009, A2. Location in patent: Page/Page column 54-55
5-Bromopyridine-3-boronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49995 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Latest Price from 5-Bromopyridine-3-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Bromopyridine-3-boronic acid
452972-09-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-08-13 | 5-Bromopyridine-3-boronic acid
452972-09-7
|
1G | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-03-20 | 5-Bromopyridine-3-boronic acid
452972-09-7
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 5-Bromopyridine-3-boronic acid
452972-09-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromopyridine-3-boronic acid
452972-09-7
- $0.00
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 5-Bromopyridine-3-boronic acid
452972-09-7
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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