3-Bromo-5-fluoropyridine
- CAS No.
- 407-20-5
- Chemical Name:
- 3-Bromo-5-fluoropyridine
- Synonyms
- 3-Br;uoropyridine;3-Bromo-5-fL;3-bromo-5-fluoropyridin;3-BROMO-5-FLUOROPYRIDINE;5-BROMO-3-FLUOROPYRIDINE;5-Fluoro-3-bromopyridine;Pyridine, 3-bromo-5-fluoro-;5-broMo-3-fluoride pyridine;3-Bromo-5-fluoropyridine98%
- CBNumber:
- CB8684466
- Molecular Formula:
- C5H3BrFN
- Molecular Weight:
- 175.99
- MDL Number:
- MFCD04112555
- MOL File:
- 407-20-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 24-28 °C |
|---|---|
| Boiling point | 78 °C / 11mmHg |
| Density | 1.707±0.06 g/cm3(Predicted) |
| Flash point | 148 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 0.45±0.20(Predicted) |
| form | Low Melting Solid or Liquid |
| color | Colorless to white |
| InChI | InChI=1S/C5H3BrFN/c6-4-1-5(7)3-8-2-4/h1-3H |
| InChIKey | HNNNBQRRIHKFLI-UHFFFAOYSA-N |
| SMILES | C1=NC=C(F)C=C1Br |
| CAS DataBase Reference | 407-20-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi,F | |||||||||
| Risk Statements | 22-37/38-41-36/37/38-20/21/22-10 | |||||||||
| Safety Statements | 26-39-36-16 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Bromo-5-fluoropyridine price More Price(83)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 646296 | 3-Bromo-5-fluoropyridine 97% | 407-20-5 | 1g | $28 | 2023-01-07 | Buy |
| Sigma-Aldrich | 646296 | 3-Bromo-5-fluoropyridine 97% | 407-20-5 | 5g | $95.5 | 2023-01-07 | Buy |
| TCI Chemical | B3244 | 3-Bromo-5-fluoropyridine >98.0%(GC) | 407-20-5 | 1g | $22 | 2026-04-30 | Buy |
| TCI Chemical | B3244 | 3-Bromo-5-fluoropyridine >98.0%(GC) | 407-20-5 | 5g | $63 | 2026-04-30 | Buy |
| Usbiological | 261714 | 3-Bromo-5-fluoropyridine Asreported | 407-20-5 | 5g | $347 | 2026-06-03 | Buy |
3-Bromo-5-fluoropyridine Chemical Properties, Uses, Production
Chemical Properties
Colorless liquid
Uses
3-Bromo-5-fluoropyridine reacts with silylformamidine to afford aminals[3]. It serves as a starting material for the synthesis of 3-(benzylthio)-5-bromopyridine[4].
Synthesis
13535-01-8
407-20-5
Step 2: Synthesis of 3-bromo-5-fluoropyridine To a cooled solution of 10.0 g (0.058 mol) of 3-amino-5-bromopyridine dissolved in 59 mL of 50% tetrafluoroboric acid was added dropwise at -10 °C a solution prepared from 4.19 g (0.06 mol) of sodium nitrite dissolved in 13 mL of water. The reaction mixture was stirred at -8°C for 1 hr and then 150 mL of ether was added. The crude diazonium salt was collected by filtration and washed with ether. Subsequently, the crude diazonium salt was added in batches to 200 mL of toluene preheated to 80°C. The reaction mixture was stirred at 90°C for 1 hour and then the organic phase was concentrated. The light yellow residue was suspended in 150 mL of water and the pH was adjusted with 32% sodium hydroxide solution to 11. The aqueous phase was extracted three times with 200 mL of dichloromethane. The organic phases were combined, washed with water, dried over magnesium sulfate, and concentrated. The crude product was purified by vacuum distillation (10 mbar, 35 °C) to give 15.4 g of brown oil, which was further purified to give 5.6 g (0.032 mol, 55% yield) of the target compound 3-bromo-5-fluoropyridine as a colorless oil (ISP): m/e = 176.1, 178.1 (M + H+).
References
[1] Patent: US2006/199960, 2006, A1. Location in patent: Page/Page column 21
[2] Recueil des Travaux Chimiques des Pays-Bas, 1955, vol. 74, p. 1062,1068
[3]
Koidan, G., Zahorulko, S., Hurieva, A., Shvydenko, T., Rusanov, E. B., Rozhenko, A. B., Manthe, U., & Kostyuk, A. (2023). Straightforward Synthesis of Halopyridine Aldehydes via Diaminomethylation. Chemistry – A European Journal, 29(55). https://doi.org/10.1002/chem.202301675
[4] Cherepakha, A. Y., Stepannikova, K. O., Vashchenko, B. V., Gorichko, M. V., Tolmachev, A. A., & Grygorenko, O. O. (2018). Hetaryl Bromides Bearing the SO2F Group – Versatile Substrates for Palladium‐Catalyzed C–C Coupling Reactions. European Journal of Organic Chemistry, 2018(47), 6682–6692. https://doi.org/10.1002/ejoc.201801270
3-Bromo-5-fluoropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Fengcheng Chemical Technology Development Co., Ltd. | 0418-2868000 13464847801 | jingxuan.lu@fcmeditech.com | China | 343 | 55 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 3-Bromo-5-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 3-Bromo-5-fluoropyridine
407-20-5
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 3-Bromo-5-fluoropyridine
407-20-5
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-06-27 | 3-Bromo-5-fluoropyridine
407-20-5
|
$10.00-30.00 | 50KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-Bromo-5-fluoropyridine
407-20-5
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 3-Bromo-5-fluoropyridine
407-20-5
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Bromo-5-fluoropyridine
407-20-5
- $10.00-30.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
