1-Boc-isonipecotic acid hydrazide
- CAS No.
- 187834-88-4
- Chemical Name:
- 1-Boc-isonipecotic acid hydrazide
- Synonyms
- tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate;KA-0848;-4-(hydrazinocarbonyL;1-boc-isonipecotis acid hydrazide;1-Boc-piperidine-4-carbohydrazide;1-Boc-isonipecotic acid hydrazide;)tetrahydro-1(2H)-pyridinecarboxyL;N-Boc-piperidine-4-carboxylhydrazide;1-Boc-piperidine-4-carboxylhydrazide;1-Boc-4-(hydrazinocarbonyl)piperidine
- CBNumber:
- CB6663186
- Molecular Formula:
- C11H21N3O3
- Molecular Weight:
- 243.3
- MDL Number:
- MFCD06795927
- MOL File:
- 187834-88-4.mol
- MSDS File:
- SDS
| Melting point | 104-106°C |
|---|---|
| Boiling point | 409.2±34.0 °C(Predicted) |
| Density | 1.147±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| form | crystalline solid |
| pka | 13.01±0.20(Predicted) |
| color | White |
| InChI | InChI=1S/C11H21N3O3/c1-11(2,3)17-10(16)14-6-4-8(5-7-14)9(15)13-12/h8H,4-7,12H2,1-3H3,(H,13,15) |
| InChIKey | JLIKTOWFNQDEME-UHFFFAOYSA-N |
| SMILES | C1C(C(NN)=O)CCN(C(=O)OC(C)(C)C)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
1-Boc-isonipecotic acid hydrazide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR14039 | 1-(tert-Butoxycarbonyl)piperidine-4-carbohydrazide ≥95% | 187834-88-4 | 1g | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR14039 | 1-(tert-Butoxycarbonyl)piperidine-4-carbohydrazide ≥95% | 187834-88-4 | 5g | $86 | 2026-06-04 | Buy |
| AK Scientific | J57911 | 1-Boc-Isonipecotic acid hydrazide 95% | 187834-88-4 | 1g | $12 | 2026-06-04 | Buy |
| AK Scientific | J57911 | 1-Boc-Isonipecotic acid hydrazide 95% | 187834-88-4 | 5g | $38 | 2026-06-04 | Buy |
| AK Scientific | J57911 | 1-Boc-Isonipecotic acid hydrazide 95% | 187834-88-4 | 10g | $67 | 2026-06-04 | Buy |
1-Boc-isonipecotic acid hydrazide Chemical Properties, Uses, Production
Uses
Ethyl N-Boc-4-piperidinecarboxylate is a key intermediate in the synthesis of sodium channel blockers used to treat stroke patients. It is also a key intermediate in the preparation of tumor necrosis factor converting enzyme inhibitors. Furthermore, it is a key intermediate in the synthesis of 1-BOC-4-piperidinecarboxylhydrazide.
Synthesis
142851-03-4
187834-88-4
The general procedure for the synthesis of 1-BOC-4-piperidinecarbohydrazide from ethyl N-Boc-4-piperidinecarboxylate is as follows: Example 4: Synthesis of tert-butyl 4-(hydrazinocarbonyl)piperidine-1-carboxylate 1. 10.0 g (38.9 mmol) of 4-tert-butyl 4-ethylpiperidine-1,4-dicarboxylate was dissolved in 35 mL of ethanol and 3.8 mL (3.90 g, 78 mmol) of hydrazine hydrate was added slowly under stirring conditions. 2. The reaction mixture was heated to reflux with continuous stirring for 9 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature, 1.9 mL (39 mmol) of hydrazine hydrate was added, and stirring was continued at reflux for 24 hours. 4. At the end of the reaction, the solvent was removed by concentration under reduced pressure and concentrated again by adding 50 mL of ethanol. 5. 150 mL of ether was added to the concentrate and the mixture was sonicated in an ultrasonic bath for 5 minutes. 6. The solid product was collected by filtration and dried to give 9.20 g of white solid in 97% yield. Product Characterization. LCMS (Method 6): Rt = 0.95 min, m/z = 244 (M+H)+ 1H-NMR (400 MHz, DMSO-d6): δ = 8.99 (s, 1H), 4.17 (br, 2H), 3.95 (br d, 2H), 2.71 (br, 2H), 2.23 (m, 1H), 1.60 (m, 2H), 1.40 (m, 11H).
References
[1] MedChemComm, 2018, vol. 9, # 12, p. 2083 - 2090
[2] Patent: US2011/144131, 2011, A1. Location in patent: Page/Page column 29
[3] Patent: WO2008/11130, 2008, A2. Location in patent: Page/Page column 151
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4430 - 4448
[5] Patent: WO2018/37223, 2018, A1. Location in patent: Page/Page column 147; 148
1-Boc-isonipecotic acid hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| YuChen Biological Medicine | 0535-7295056 15692356085 | sdycc1234@163.com | China | 133 | 58 |
| Shanghai Hobor Chemical Co., Ltd | 13918007836 | sales@hoborchem.com | China | 423 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Bayee Biotech (Anqing) Co., Ltd. | 0556-5032306 18917961636 | wtx@bayeebio.com | China | 145 | 61 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Changzhou Wanyao Biotechnology Co., Ltd. | 0519-89185693 15312551983 | 2410037592@qq.com | China | 278 | 55 |
View Latest Price from 1-Boc-isonipecotic acid hydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 1-BOC-ISONIPECOTIC ACID HYDRAZIDE
187834-88-4
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 1-BOC-ISONIPECOTIC ACID HYDRAZIDE
187834-88-4
- $1.00
- 98%
- Career Henan Chemical Co
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