7,3',4'-Trihydroxyflavanone
- CAS No.
- 21913-99-5
- Chemical Name:
- 7,3',4'-Trihydroxyflavanone
- Synonyms
- BUTIN;3',4',7-trihydroxyflavanone;7,3',4'-Trihydroxyflavanone;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-
- CBNumber:
- CB6701532
- Molecular Formula:
- C15H12O5
- Molecular Weight:
- 272.25
- MDL Number:
- MFCD21606964
- MOL File:
- Mol file
- MSDS File:
- SDS
7,3',4'-Trihydroxyflavanone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40268 | Butin ≥98% | 21913-99-5 | 1mg | $50 | 2026-04-30 | Buy |
| Cayman Chemical | 40268 | Butin ≥98% | 21913-99-5 | 5mg | $224 | 2026-04-30 | Buy |
| Cayman Chemical | 40268 | Butin ≥98% | 21913-99-5 | 10mg | $396 | 2026-04-30 | Buy |
| Biosynth | WAA91399 | 3',4',7-Trihydroxyflavanone | 21913-99-5 | 25mg | $1164.25 | 2026-06-05 | Buy |
| Biosynth | WAA91399 | 3',4',7-Trihydroxyflavanone | 21913-99-5 | 50mg | $1620 | 2026-06-05 | Buy |
7,3',4'-Trihydroxyflavanone Chemical Properties,Uses,Production
Uses
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat[1][2].
Definition
ChEBI: 2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one is a member of flavanones.
in vivo
Butin (10-40 mg/kg, orally, twice a day, 15 days) can significantly reduce myocardial ischemia-reperfusion injury in diabetic mice, improve heart function, and increase the ability to resist oxidative stress[1].
Butin (25-50 mg/kg, intraperitoneal injection, single dose) can reduce behavioral changes and neuronal conditions in rats with cerebral hemorrhage by reducing apoptosis and inflammatory responses[2].
| Animal Model: | C57/BL6J mice induced by STZ(HY-13753)[1] |
| Dosage: | 10, 20, 40 mg/kg; twice a day; 15 days |
| Administration: | Oral |
| Result: | Improved cardiac function, significant increases in LVSP, +dP/dtmax and -dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity. |
| Animal Model: | Intracerebral hemorrhage rats[2] |
| Dosage: | 25, 50 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6). |
References
[1] Duan J, et al. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017 Jan 27;7:41491. DOI:10.1038/srep41491
[2] Li P, et al. Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. Transl Neurosci. 2018 May 8;9:7-12. DOI:10.1515/tnsci-2018-0002
[3] JINPENG LV . Synthesis and melanogenesis evaluation of 3′,4′,7-trihydroxyflavanone derivatives and characterization of flavanone–BODIPY[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25 7: Pages 1607-1610. DOI: 10.1016/j.bmcl.2015.01.072
[4] S. MILOSAVLJEVIC. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA[J]. Natural Product Communications, 2021, 53 1. DOI: 10.1177/1934578x211067289
[5] BHARGAVA S K. Estrogenic and postcoital anticonceptive activity in rats of butin isolated from Butea monosperma seed[J]. Journal of ethnopharmacology, 1986, 18 1: Pages 95-101. DOI: 10.1016/0378-8741(86)90046-2
7,3',4'-Trihydroxyflavanone Preparation Products And Raw materials
Raw materials
Preparation Products
7,3',4'-Trihydroxyflavanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChengDu Yijierui Biotechnology CO., Ltd | 18224018291 18224018291 | yirui307@163.com | China | 996 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChengDu YiRui Bio-Technology CO., LTD | 18224028459 18224028459 | yirui307@163.com | China | 995 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Shanghai Anbida Biotechnology Co., Ltd. | 021-61629020 18201956406 | sales@ambeed.cn | China | 7032 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
