Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate
- CAS No.
- 35975-57-6
- Chemical Name:
- Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate
- Synonyms
- Ux00004205;BUTTPARK 89\01-99;Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate;ETHYL 8-BROMO-4-HYDROXY-3-QUINOLINECARBOXYLATE;Ethyl 4-hydroxy-8-broMoquinoline-3-carboxylate;8-Bromo-4-hydroxy-3-quinolinecarboxylic acid ethyl ester;8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;4-Hydroxy-8-broMoquinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 8-bromo-4-hydroxy-, ethyl ester;ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB6718448
- Molecular Formula:
- C12H10BrNO3
- Molecular Weight:
- 296.12
- MDL Number:
- MFCD00173380
- MOL File:
- 35975-57-6.mol
- MSDS File:
- SDS
| Boiling point | 385.5±37.0 °C(Predicted) |
|---|---|
| Density | 1.593±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 2.16±0.50(Predicted) |
| form | solid |
| Appearance | Off-white to light brown Solid |
| InChI | InChI=1S/C12H10BrNO3/c1-2-17-12(16)8-6-14-10-7(11(8)15)4-3-5-9(10)13/h3-6H,2H2,1H3,(H,14,15) |
| InChIKey | XDDQBYKFJZYKPE-UHFFFAOYSA-N |
| SMILES | N1C2C(=CC=CC=2Br)C(O)=C(C(OCC)=O)C=1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| HS Code | 2933499090 |
| Storage Class | 11 - Combustible Solids |
Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BBO000225 | 8-Bromo-4-hydroxyquinoline-3-carboxylic acid ethyl ester Aldrich | 35975-57-6 | 1g | $276 | 2026-04-30 | Buy |
| Apolloscientific | OR11682 | Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate ≥95% | 35975-57-6 | 1g | $21 | 2026-06-04 | Buy |
| Synthonix | E55585 | Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate 97% | 35975-57-6 | 100mg | $16 | 2026-05-06 | Buy |
| Synthonix | E55585 | Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate 97% | 35975-57-6 | 250mg | $20 | 2026-05-06 | Buy |
| Synthonix | E55585 | Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate 97% | 35975-57-6 | 1g | $22 | 2026-05-06 | Buy |
Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate Chemical Properties, Uses, Production
Synthesis
87-13-8
615-36-1
35975-57-6
The reaction was carried out with 2-bromoaniline (2.5 g, 14.62 mmol) and diethyl ethoxymethylene malonate (3.16 g, 14.62 mmol) by heating at 100 °C for 3 hours. Subsequently, the volatiles in the reaction system were removed by a stream of nitrogen. The resulting melt was slowly added to boiling diphenyl ether (10 mL) and the mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was allowed to cool to room temperature and petroleum ether was added to precipitate the product. The precipitated solid was collected by filtration and dried to give ethyl 4-hydroxy-8-bromoquinoline-3-carboxylate (3.5 g). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 11.65 (br s, 1H), 8.45 (s, 1H), 8.17 (d, J = 7.8 Hz, 1H), 8.05 (d, J = 7.8 Hz, 1H), 7.39-7.34 (t, J = 7.8 Hz, 1H), 4.26-4.19 (q, J = 7.2,14.1Hz, 2H), 1.30-1.26 (t, J = 6.9Hz, 3H).
References
[1] Journal of Organic Chemistry, 2017, vol. 82, # 24, p. 13756 - 13767
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 8, p. 1487 - 1490
[3] Patent: US2003/144507, 2003, A1
[4] Patent: EP1258252, 2002, A1
[5] Patent: US2004/18192, 2004, A1
Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Anmike Chemical Co. Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 9988 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from Ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
35975-57-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-23 | ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
35975-57-6
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
35975-57-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- ETHYL 8-BROMO-4-HYDROXYQUINOLINE-3-CARBOXYLATE
35975-57-6
- $1.00
- 99%
- Career Henan Chemical Co
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