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2-Hydroxy-1-(4-nitrophenyl)-1-ethanone

2-Hydroxy-1-(4-nitrophenyl)-1-ethanone Structure
2-Hydroxy-1-(4-nitrophenyl)-1-ethanone structure
CAS No.
64611-67-2
Chemical Name:
2-Hydroxy-1-(4-nitrophenyl)-1-ethanone
Synonyms
2-hydroxy-1-(4-nitrophenyl)ethan-1-one;2-Hydroxy-4'-nitroacetophenone;2-Hydroxy-1-(4-nitrophenyl)ethanone;2-Hydroxy-1-(4-nitrophenyl)-1-ethanone;Ethanone, 2-hydroxy-1-(4-nitrophenyl)-
CBNumber:
CB7116386
Molecular Formula:
C8H7NO4
Molecular Weight:
181.15
MDL Number:
MFCD00599385
MOL File:
64611-67-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:27
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2-Hydroxy-1-(4-nitrophenyl)-1-ethanone Properties

Melting point 140-143°C
Boiling point 338.4±17.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form solid
pka 12.42±0.10(Predicted)
InChI InChI=1S/C8H7NO4/c10-5-8(11)6-1-3-7(4-2-6)9(12)13/h1-4,10H,5H2
InChIKey DRGHCHSDUDQWHJ-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C([N+]([O-])=O)C=C1)CO
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
HazardClass  IRRITANT
Storage Class 11 - Combustible Solids

2-Hydroxy-1-(4-nitrophenyl)-1-ethanone price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich KOB0089 2-Hydroxy-1-(4-nitrophenyl)-1-ethanone 64611-67-2 1g $276 2026-04-30 Buy
Activate Scientific AS90597 2-Hydroxy-4'-nitroacetophenone 98% 64611-67-2 1g $108 2026-06-04 Buy
Activate Scientific AS90597 2-Hydroxy-4'-nitroacetophenone 98% 64611-67-2 5g $369 2026-06-04 Buy
Matrix Scientific 296982 2-Hydroxy-1-(4-nitrophenyl)ethanone 64611-67-2 1.00g $71 2026-05-19 Buy
Matrix Scientific 296982 2-Hydroxy-1-(4-nitrophenyl)ethanone 64611-67-2 5.00g $239 2026-05-19 Buy
Product number Packaging Price Buy
KOB0089 1g $276 Buy
AS90597 1g $108 Buy
AS90597 5g $369 Buy
296982 1.00g $71 Buy
296982 5.00g $239 Buy

2-Hydroxy-1-(4-nitrophenyl)-1-ethanone Chemical Properties, Uses, Production

Synthesis

2-Bromo-4'-nitroacetophenone

99-81-0

2-HYDROXY-1-(4-NITROPHENYL)-1-ETHANONE

64611-67-2

Example 13A Synthesis of 2-hydroxy-1-(4-nitrophenyl)ethanone: 2-bromo-1-(4-nitrophenyl)ethanone (5 g, 20.5 mmol) and silver nitrate (5 g, 29.4 mmol) were dissolved in a solvent mixture of water (250 mL) and acetone (150 mL) and heated to reflux the reaction for 4 hours. After the reaction was completed, it was cooled to room temperature. The reaction mixture was filtered and the filtrate was extracted twice with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. The concentrate was purified by silica gel fast column chromatography with 2:1 hexane/ethyl acetate as eluent to give 3.7 g (50% yield) of the target product 2-hydroxy-1-(4-nitrophenyl)ethanone. Thin layer chromatography (TLC) showed an Rf value of 0.4 (eluent ratio 1:1 hexane/ethyl acetate).

References

[1] Advanced Synthesis and Catalysis, 2016, vol. 358, # 1, p. 74 - 80
[2] Journal of Organic Chemistry, 1989, vol. 54, # 18, p. 4473 - 4474
[3] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 142 - 151
[4] Patent: US2003/225098, 2003, A1. Location in patent: Page 32
[5] Chemische Berichte, 1889, vol. 22, p. 203

2-Hydroxy-1-(4-nitrophenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

2-Bromo-4'-nitroacetophenone Water Silver nitrate Acetone

Preparation Products

2-Hydroxy-1-(4-nitrophenyl)-1-ethanone Suppliers

Global Suppliers ( 45)
Supplier Tel Email Country ProdList Advantage
Zhengzhou Guancheng Laboratory equipment Sales 0371-88888888 qq272369594;2159423853qq 2723695949@qq.com China 4990 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Jovan Biochemical Technology Co. Ltd. +86-021-61654350 1245958370@qq.com China 2979 50
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 028-83379370 13880556291 tcy@tcypharm.com China 8696 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Nanjing KaiMubo Pharmaceutical Co., Ltd. 025-66162170 China 7180 55
Beijing YiboYuntian Technology Co., Ltd. 13811826434 lichen13811826434@126.com China 702 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Supplier Advantage
Zhengzhou Guancheng Laboratory equipment Sales 50
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Jovan Biochemical Technology Co. Ltd. 50
ChengDu TongChuangYuan Pharmaceutical Co.Ltd 58
Amadis Chemical Company Limited 58
Nanjing KaiMubo Pharmaceutical Co., Ltd. 55
Beijing YiboYuntian Technology Co., Ltd. 58
Aikon International Limited 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58

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Ethanone, 2-hydroxy-1-(4-nitrophenyl)- 2-Hydroxy-1-(4-nitrophenyl)ethanone 2-Hydroxy-4'-nitroacetophenone 2-hydroxy-1-(4-nitrophenyl)ethan-1-one 2-Hydroxy-1-(4-nitrophenyl)-1-ethanone 64611-67-2