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SC-51322

SC-51322 structure

CAS No.: 146032-79-3

Chemical Name:: SC-51322

Synonyms: SC-51322;SC-51322, EP1 receptor antagonist;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide;8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide;Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide

CBNumber:: CB7235197

Molecular Formula:: C22H20ClN3O4S

Molecular Weight:: 457.93

MDL Number:: MFCD00916246

MOL File:: Mol file

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:07:59

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SC-51322 Properties

Melting point	112-114°C
RTECS	HQ4002000
storage temp.	Store at +4°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to off-white
InChI	1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28)
InChIKey	CQBVTZDISUKDSX-UHFFFAOYSA-N
SMILES	Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCSCc4ccco4)c2c1
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

HazardClass

6.1

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

NFPA 704

	0
2		0

SC-51322 price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0132	SC-51322 ≥98% (HPLC)	146032-79-3	5mg	$40.8	2024-03-01	Buy
Sigma-Aldrich	PZ0132	SC-51322 ≥98% (HPLC)	146032-79-3	25mg	$404	2024-03-01	Buy
Cayman Chemical	10010744	SC-51322 ≥98%	146032-79-3	1mg	$22	2026-04-30	Buy
Cayman Chemical	10010744	SC-51322 ≥98%	146032-79-3	5mg	$94	2026-04-30	Buy
Cayman Chemical	10010744	SC-51322 ≥98%	146032-79-3	10mg	$161	2026-04-30	Buy

Product number	Packaging	Price	Buy
PZ0132	5mg	$40.8	Buy
PZ0132	25mg	$404	Buy
10010744	1mg	$22	Buy
10010744	5mg	$94	Buy
10010744	10mg	$161	Buy

SC-51322 Chemical Properties, Uses, Production

Description

The prostaglandin E₂ (PGE₂) receptor (EP₁) is involved in triggering PGE₂-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP₁ antagonist that inhibits PGE₂ signaling in a guinea pig ileum muscle strip assay with a pA₂ value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED₅₀ value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE₂ with an EC₅₀ value of 7.75 μM.

Chemical Properties

Off-White Solid

Uses

A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.

IC 50

EP2: 8.1 (pA2)

storage

Store at -20°C

References

[1] E. ANN HALLINAN. Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs[J]. Journal of Medicinal Chemistry, 1996, 39 2: 609-613. DOI: 10.1021/jm950454k
[2] N FOUDI. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype[J]. British Journal of Pharmacology, 2009, 154 8: 1631-1639. DOI: 10.1038/bjp.2008.214

SC-51322 Preparation Products And Raw materials

Raw materials

Preparation Products

SC-51322 Suppliers

Global Suppliers ( 44)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	57336	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Energy Chemical	400-0056266	marketing1@energy-chemical.com	China	44927	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50
Guangzhou Isun Pharmaceutical Co., Ltd	55
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58

View Latest Price from SC-51322 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	SC 51322 146032-79-3	$69.00-529.00			10g	TargetMol Chemicals Inc.

SC 51322
146032-79-3
$69.00-529.00
TargetMol Chemicals Inc.

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SC-51322 8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide Dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide SC-51322, EP1 receptor antagonist 146032-79-3 Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer compounds Pharmaceuticals Sulfur & Selenium Compounds