SC-51322 manufacturers
- SC 51322
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- $69.00
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2026-05-11
- CAS:146032-79-3
- Purity:
- Supply Ability: 10g
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| | SC-51322 Basic information |
| | SC-51322 Chemical Properties |
| Melting point | 112-114°C | | RTECS | HQ4002000 | | storage temp. | Store at +4°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | white to off-white | | InChI | 1S/C22H20ClN3O4S/c23-16-7-8-20-18(12-16)26(13-15-4-1-2-6-19(15)30-20)22(28)25-24-21(27)9-11-31-14-17-5-3-10-29-17/h1-8,10,12H,9,11,13-14H2,(H,24,27)(H,25,28) | | InChIKey | CQBVTZDISUKDSX-UHFFFAOYSA-N | | SMILES | Clc1ccc2Oc3ccccc3CN(C(=O)NNC(=O)CCSCc4ccco4)c2c1 |
| Hazard Codes | T | | Risk Statements | 25 | | Safety Statements | 45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HazardClass | 6.1 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | SC-51322 Usage And Synthesis |
| Description | The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 μM. | | Chemical Properties | Off-White Solid | | Uses | A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects. | | IC 50 | EP2: 8.1 (pA2) | | storage | Store at -20°C | | References | [1] E. ANN HALLINAN. Aminoacetyl Moiety as a Potential Surrogate for Diacylhydrazine Group of SC-51089, a Potent PGE2 Antagonist, and Its Analogs[J]. Journal of Medicinal Chemistry, 1996, 39 2: 609-613. DOI: 10.1021/jm950454k
[2] N FOUDI. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype[J]. British Journal of Pharmacology, 2009, 154 8: 1631-1639. DOI: 10.1038/bjp.2008.214 |
| | SC-51322 Preparation Products And Raw materials |
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