2-Cyano-3-hydroxypyridine
- CAS No.
- 932-35-4
- Chemical Name:
- 2-Cyano-3-hydroxypyridine
- Synonyms
- 3-hydroxy-2-cyanopyridine;3-hydroxy-2-cyanopy;2-Cyano-pyridin-3-ol;2-Cyano-3-hydroxpyridine;3-HYDROXYPICOLINONITRILE;2-Cyano-3-hydroxypyridine;2-Cyano-3-hydroxypyridine >3-hydroxypyridin-2-carbonitril;3-Hydroxy-2-pyridinecarbonitrile;3-HYDROXY-PYRIDINE-2-CARBONITRILE
- CBNumber:
- CB7330449
- Molecular Formula:
- C6H4N2O
- Molecular Weight:
- 120.11
- MDL Number:
- MFCD01646135
- MOL File:
- 932-35-4.mol
- MSDS File:
- SDS
| Melting point | 211-212 °C (decomp) |
|---|---|
| Boiling point | 429.2±30.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 2.58±0.10(Predicted) |
| color | Yellow to Dark Yellow |
| InChI | InChI=1S/C6H4N2O/c7-4-5-6(9)2-1-3-8-5/h1-3,9H |
| InChIKey | XTVFTOVNAKNVQK-UHFFFAOYSA-N |
| SMILES | C1(C#N)=NC=CC=C1O |
| CAS DataBase Reference | 932-35-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501 | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-39 | |||||||||
| RIDADR | 3439 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Cyano-3-hydroxypyridine price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1664 | 2-Cyano-3-hydroxypyridine >98.0%(GC)(T) | 932-35-4 | 5g | $215 | 2026-04-30 | Buy |
| TCI Chemical | C1664 | 2-Cyano-3-hydroxypyridine >98.0%(GC)(T) | 932-35-4 | 25g | $789 | 2026-04-30 | Buy |
| TRC | TRC-C987963-500MG | 2-Cyano-3-hydroxypyridine | 932-35-4 | 500mg | $90 | 2026-06-03 | Buy |
| TRC | TRC-C987963-250MG | 2-Cyano-3-hydroxypyridine | 932-35-4 | 250mg | $75 | 2026-06-03 | Buy |
| TRC | TRC-C987963-100MG | 2-Cyano-3-hydroxypyridine | 932-35-4 | 100mg | $63 | 2026-06-03 | Buy |
2-Cyano-3-hydroxypyridine Chemical Properties, Uses, Production
Uses
2-Cyano-3-hydroxypyridine can be used as eIF4A inhibitors.
Synthesis
62626-61-3
932-35-4
Example 3: 5.0 g of 1N hydrochloric acid and 1.0 g (6.31 mmol) of α-amino-2-furan acetonitrile hydrochloride were added to a three-neck flask at room temperature. The reaction mixture was cooled to 0 °C and 360 μL of bromine (6.94 mmol) was slowly added dropwise, followed by stirring at 0 °C for 1 hour. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. After that, 32 μL of bromine was added to the reaction system and stirring was continued for 2 hours. Again, 32 μL of bromine was added and stirred for 1 hour. Upon completion of the reaction, 199 mg of sodium thiosulfate was added to the mixture to quench the reaction, followed by adjusting the pH with 40% NaOH aqueous solution to 3.0. The reaction mixture was filtered to afford a product containing 0.47 g of 2-cyano-3-hydroxypyridine. The yield of 2-cyano-3-hydroxypyridine was 62% based on the amount of α-amino-2-furylacetonitrile hydrochloride.
References
[1] Patent: TW2016/510, 2016, A. Location in patent: Page/Page column 14
[2] Patent: WO2017/127794, 2017, A1
[3] Patent: WO2017/127791, 2017, A1
[4] Patent: TW2018/27404, 2018, A
2-Cyano-3-hydroxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan LuoHe PharmaTech Co., Ltd. | 86-0531-68658065 15726150375 | 1071018499@qq.com | China | 525 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from 2-Cyano-3-hydroxypyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-19 | 2-Cyano-3-hydroxypyridine
932-35-4
|
1kg | 95.0% | 1000kg | Shanghai Joiny Pharmaceutical Co.,LTD | ||
 |
2025-06-25 | 2-CYANO-3-HYDROXYPYRIDINE
932-35-4
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-11-11 | 2-Cyano-3-hydroxypyridine
932-35-4
|
1g | 97-99.9% | 20kgs/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 2-Cyano-3-hydroxypyridine
932-35-4
- $0.00
- 95.0%
- Shanghai Joiny Pharmaceutical Co.,LTD
-
- 2-CYANO-3-HYDROXYPYRIDINE
932-35-4
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Cyano-3-hydroxypyridine
932-35-4
- $0.00
- 97-99.9%
- Nanjing jinheyou Trading Co., Ltd.
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