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4-Cbz-Aminopiperidine

4-Cbz-Aminopiperidine Structure
4-Cbz-Aminopiperidine structure
CAS No.
182223-54-7
Chemical Name:
4-Cbz-Aminopiperidine
Synonyms
4-CBZ-AMINOPIPERIDINE;4-(Z-amino)-piperidine;N-CBZ-piperidin-4-aMine;Benzylpiperidin-4-ylcarbamate;Benzyl 4-Piperidinylcarbamate;4-Benzyloxycarbonylamino-piperdine;benzyl N-(piperidin-4-yl)carbaMate;4-BENZYLOXYCARBONYLAMINO-PIPERIDINE;Phenylmethyl N-4-piperidinylcarbamate;4-(N-Benzyloxycarbonyl)-aminopiperidine
CBNumber:
CB7756599
Molecular Formula:
C13H18N2O2
Molecular Weight:
234.29
MDL Number:
MFCD04038571
MOL File:
182223-54-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:28:46
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4-Cbz-Aminopiperidine Properties

Boiling point 396.3±41.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Dichloromethane
form Solid
pka 12.18±0.20(Predicted)
color White
InChI InChI=1S/C13H18N2O2/c16-13(15-12-6-8-14-9-7-12)17-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2,(H,15,16)
InChIKey WWGUAFRTAYMNHU-UHFFFAOYSA-N
SMILES C(OCC1=CC=CC=C1)(=O)NC1CCNCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety Statements  24/25
HS Code  29333990

4-Cbz-Aminopiperidine price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 430459 4-Benzyloxycarbonylaminopiperidine 182223-54-7 250mg $319 2026-06-03 Buy
Usbiological 430459 4-Benzyloxycarbonylaminopiperidine 182223-54-7 500mg $446 2026-06-03 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 5g $900 2026-06-04 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 50g $900 2026-06-04 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 2g $900 2026-06-04 Buy
Product number Packaging Price Buy
430459 250mg $319 Buy
430459 500mg $446 Buy
FC148389 5g $900 Buy
FC148389 50g $900 Buy
FC148389 2g $900 Buy

4-Cbz-Aminopiperidine Chemical Properties,Uses,Production

Uses

4-Benzyloxycarbonylaminopiperidine is an intermediate in synthesizing 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin (E899150), a major metabolite of Irinotecan.

Definition

ChEBI: Benzyl 4-piperidinylcarbamate is a member of piperidines.

Synthesis

1-BOC-4-CBZ-AMINO-PIPERIDINE

220394-97-8

4-Cbz-Aminopiperidine

182223-54-7

The general procedure for the synthesis of 4-(N-benzyloxycarbonyl)-aminopiperidine from 1-Boc-4-(Cbz-amino)piperidine was as follows: tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (13.1 g, 39.2 mmol) obtained in Example 1a was mixed with a 5N aqueous hydrochloric acid (40 ml, 200 mmol) and a methanolic (40 ml) The mixture was stirred at room temperature for 23 hours. After completion of the reaction, 5N aqueous sodium hydroxide solution (40 ml) was slowly added to the reaction mixture under ice bath cooling conditions. Subsequently, water and solvent were removed from the reaction mixture by distillation while azeotropic distillation using ethanol was carried out to remove water completely. Ethanol was added to the distilled residue, filtered to remove insoluble matter, and the filtrate was concentrated to give the final 4-(N-benzyloxycarbonyl)-aminopiperidine (9.10 g, 99.1% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts δppm: 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J = 12Hz), 3.10 (2H, d, J = 12Hz), 3.56-3.68 (1H, br), 4.72- 4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).

References

[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0149
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1021 - 1046
[4] Patent: WO2011/60321, 2011, A1. Location in patent: Page/Page column 115
[5] Patent: WO2006/99884, 2006, A1. Location in patent: Page/Page column 18

4-Cbz-Aminopiperidine Preparation Products And Raw materials

Raw materials

1-Boc-4-Cbz-amino-piperidine Hydrochloric acid Water Methanol

Preparation Products

1-Isopropyl-piperidin-4-ylamine 4-(Cbz-aMino)-1-(Methylsulfonyl)piperidine

4-Cbz-Aminopiperidine Suppliers

Global( 118)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Sichuan Guanghan Bio-Tech Co., Ltd +86-28-86127071 info@sino-produce.com China 400 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shanghai Aobo pharmaceutical Technology Co., Ltd 86-21-51320499 aobo@aobopharm.com China 297 57
Supplier Advantage
Shanghai Hobor Chemical Co., Ltd 60
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Energy Chemical 61
Capot Chemical Co., Ltd 66
Sichuan Guanghan Bio-Tech Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59
China DongFan Chemical Co.,LTD 66
Shanghai Aobo pharmaceutical Technology Co., Ltd 57

View Lastest Price from 4-Cbz-Aminopiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-CBZ-piperidin-4-aMine pictures 2021-07-02 N-CBZ-piperidin-4-aMine
182223-54-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-Cbz-Aminopiperidine pictures 2019-07-06 4-Cbz-Aminopiperidine
182223-54-7
 $1.00 1KG 98% 100KG Career Henan Chemical Co

4-Cbz-Aminopiperidine Spectrum

4-Cbz-Aminopiperidine(182223-54-7)1HNMR

182223-54-7(4-Cbz-Aminopiperidine)Related Search:

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1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)- 1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID 4-BENZYLOXYCARBONYLAMINO-4-METHYL-PIPERIDINE L371,257 METHYL-(1-METHYL-4-PYRROLIDIN-1-YLMETHYL-PIPERIDIN-4-YL)-CARBAMIC ACID BENZYL ESTER
4-Benzyloxy-carbonyl-amino-1-n-butoxy-carbonyl-4-methyl piperidine 4-Cbz-Aminopiperidine (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

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Carbamic acid, 4-piperidinyl-, phenylmethyl ester benzyl piperidin-4-ylcarbamate hydrochloride N-CBZ-piperidin-4-aMine benzyl N-(piperidin-4-yl)carbaMate 4-Benzyloxycarbonylamino-piperdine 4-CBZ-AMINOPIPERIDINE 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE Carbamic acid, 4-piperidinyl-, phenylmethyl ester (9CI) Benzylpiperidin-4-ylcarbamate Carbamic acid, N-4-piperidinyl-, phenylmethyl ester 4-(Z-amino)-piperidine Benzyl 4-Piperidinylcarbamate Phenylmethyl N-4-piperidinylcarbamate 4-(N-Benzyloxycarbonyl)-aminopiperidine 182223-54-7 pharmacetical API intermediates N-CBZ