4-Cbz-Aminopiperidine
- CAS No.
- 182223-54-7
- Chemical Name:
- 4-Cbz-Aminopiperidine
- Synonyms
- 4-CBZ-AMINOPIPERIDINE;4-(Z-amino)-piperidine;N-CBZ-piperidin-4-aMine;Benzylpiperidin-4-ylcarbamate;Benzyl 4-Piperidinylcarbamate;4-Benzyloxycarbonylamino-piperdine;benzyl N-(piperidin-4-yl)carbaMate;4-BENZYLOXYCARBONYLAMINO-PIPERIDINE;Phenylmethyl N-4-piperidinylcarbamate;benzyl piperidin-4-ylcarbamate hydrochloride
- CBNumber:
- CB7756599
- Molecular Formula:
- C13H18N2O2
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD04038571
- MOL File:
- 182223-54-7.mol
| Boiling point | 396.3±41.0 °C(Predicted) |
|---|---|
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Dichloromethane |
| form | Solid |
| pka | 12.18±0.20(Predicted) |
| color | White |
| InChI | InChI=1S/C13H18N2O2/c16-13(15-12-6-8-14-9-7-12)17-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2,(H,15,16) |
| InChIKey | WWGUAFRTAYMNHU-UHFFFAOYSA-N |
| SMILES | C(OCC1=CC=CC=C1)(=O)NC1CCNCC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Safety Statements | 24/25 |
| HS Code | 29333990 |
4-Cbz-Aminopiperidine price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B285871 | 4-Benzyloxycarbonylaminopiperidine | 182223-54-7 | 1g | $165 | 2021-12-16 | Buy |
| TRC | B285871 | 4-Benzyloxycarbonylaminopiperidine | 182223-54-7 | 2.5g | $330 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK501176 | 4-Cbz-aminopiperidine 97% | 182223-54-7 | 1g | $385 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC148389 | 4-Cbz-aminopiperidine | 182223-54-7 | 5G | $400 | 2021-12-16 | Buy |
| Apolloscientific | OR301035 | 4-Benzyloxycarbonylaminopiperidine | 182223-54-7 | 10g | $508 | 2021-12-16 | Buy |
4-Cbz-Aminopiperidine Chemical Properties,Uses,Production
Uses
4-Benzyloxycarbonylaminopiperidine is an intermediate in synthesizing 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin (E899150), a major metabolite of Irinotecan.
Definition
ChEBI: Benzyl 4-piperidinylcarbamate is a member of piperidines.
Synthesis
220394-97-8
182223-54-7
The general procedure for the synthesis of 4-(N-benzyloxycarbonyl)-aminopiperidine from 1-Boc-4-(Cbz-amino)piperidine was as follows: tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (13.1 g, 39.2 mmol) obtained in Example 1a was mixed with a 5N aqueous hydrochloric acid (40 ml, 200 mmol) and a methanolic (40 ml) The mixture was stirred at room temperature for 23 hours. After completion of the reaction, 5N aqueous sodium hydroxide solution (40 ml) was slowly added to the reaction mixture under ice bath cooling conditions. Subsequently, water and solvent were removed from the reaction mixture by distillation while azeotropic distillation using ethanol was carried out to remove water completely. Ethanol was added to the distilled residue, filtered to remove insoluble matter, and the filtrate was concentrated to give the final 4-(N-benzyloxycarbonyl)-aminopiperidine (9.10 g, 99.1% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts δppm: 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J = 12Hz), 3.10 (2H, d, J = 12Hz), 3.56-3.68 (1H, br), 4.72- 4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).
References
[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0149
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1021 - 1046
[4] Patent: WO2011/60321, 2011, A1. Location in patent: Page/Page column 115
[5] Patent: WO2006/99884, 2006, A1. Location in patent: Page/Page column 18
4-Cbz-Aminopiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10244 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14459 | 58 |
View Lastest Price from 4-Cbz-Aminopiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | N-CBZ-piperidin-4-aMine
182223-54-7
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | 4-Cbz-Aminopiperidine
182223-54-7
|
US $1.00 / KG | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- N-CBZ-piperidin-4-aMine
182223-54-7
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-Cbz-Aminopiperidine
182223-54-7
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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