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4-Cbz-Aminopiperidine

4-Cbz-Aminopiperidine Structure
4-Cbz-Aminopiperidine structure
CAS No.
182223-54-7
Chemical Name:
4-Cbz-Aminopiperidine
Synonyms
4-CBZ-AMINOPIPERIDINE;4-(Z-amino)-piperidine;N-CBZ-piperidin-4-aMine;Benzylpiperidin-4-ylcarbamate;Benzyl 4-Piperidinylcarbamate;4-Benzyloxycarbonylamino-piperdine;benzyl N-(piperidin-4-yl)carbaMate;4-BENZYLOXYCARBONYLAMINO-PIPERIDINE;Phenylmethyl N-4-piperidinylcarbamate;benzyl piperidin-4-ylcarbamate hydrochloride
CBNumber:
CB7756599
Molecular Formula:
C13H18N2O2
Molecular Weight:
234.29
MDL Number:
MFCD04038571
MOL File:
182223-54-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:28:46
Product description Number Pack Size Price
4-Benzyloxycarbonylaminopiperidine 430459 250mg $319
4-Benzyloxycarbonylaminopiperidine 430459 500mg $446
4-Cbz-aminopiperidine FC148389 5g $900
4-Cbz-aminopiperidine FC148389 50g $900
4-Cbz-aminopiperidine FC148389 2g $900
More product size
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4-Cbz-Aminopiperidine Properties

Boiling point 396.3±41.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Dichloromethane
form Solid
pka 12.18±0.20(Predicted)
color White
InChI InChI=1S/C13H18N2O2/c16-13(15-12-6-8-14-9-7-12)17-10-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2,(H,15,16)
InChIKey WWGUAFRTAYMNHU-UHFFFAOYSA-N
SMILES C(OCC1=CC=CC=C1)(=O)NC1CCNCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety Statements  24/25
HS Code  29333990

4-Cbz-Aminopiperidine price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 430459 4-Benzyloxycarbonylaminopiperidine 182223-54-7 250mg $319 2026-06-03 Buy
Usbiological 430459 4-Benzyloxycarbonylaminopiperidine 182223-54-7 500mg $446 2026-06-03 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 5g $900 2026-06-04 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 50g $900 2026-06-04 Buy
Biosynth FC148389 4-Cbz-aminopiperidine 182223-54-7 2g $900 2026-06-04 Buy
Product number Packaging Price Buy
430459 250mg $319 Buy
430459 500mg $446 Buy
FC148389 5g $900 Buy
FC148389 50g $900 Buy
FC148389 2g $900 Buy

4-Cbz-Aminopiperidine Chemical Properties,Uses,Production

Uses

4-Benzyloxycarbonylaminopiperidine is an intermediate in synthesizing 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin (E899150), a major metabolite of Irinotecan.

Definition

ChEBI: Benzyl 4-piperidinylcarbamate is a member of piperidines.

Synthesis

1-BOC-4-CBZ-AMINO-PIPERIDINE

220394-97-8

4-Cbz-Aminopiperidine

182223-54-7

The general procedure for the synthesis of 4-(N-benzyloxycarbonyl)-aminopiperidine from 1-Boc-4-(Cbz-amino)piperidine was as follows: tert-butyl 4-{[(benzyloxy)carbonyl]amino}piperidine-1-carboxylate (13.1 g, 39.2 mmol) obtained in Example 1a was mixed with a 5N aqueous hydrochloric acid (40 ml, 200 mmol) and a methanolic (40 ml) The mixture was stirred at room temperature for 23 hours. After completion of the reaction, 5N aqueous sodium hydroxide solution (40 ml) was slowly added to the reaction mixture under ice bath cooling conditions. Subsequently, water and solvent were removed from the reaction mixture by distillation while azeotropic distillation using ethanol was carried out to remove water completely. Ethanol was added to the distilled residue, filtered to remove insoluble matter, and the filtrate was concentrated to give the final 4-(N-benzyloxycarbonyl)-aminopiperidine (9.10 g, 99.1% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3) with the following chemical shifts δppm: 1.31-1.42 (2H, m), 1.92-2.04 (2H, br), 2.70 (2H, d, J = 12Hz), 3.10 (2H, d, J = 12Hz), 3.56-3.68 (1H, br), 4.72- 4.81 (1H, br), 5.09 (2H, s), 7.26-7.40 (5H, m).

References

[1] Patent: US2013/65925, 2013, A1. Location in patent: Paragraph 0197; 0198
[2] Patent: EP2757103, 2014, A1. Location in patent: Paragraph 0149
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 3, p. 1021 - 1046
[4] Patent: WO2011/60321, 2011, A1. Location in patent: Page/Page column 115
[5] Patent: WO2006/99884, 2006, A1. Location in patent: Page/Page column 18

4-Cbz-Aminopiperidine Preparation Products And Raw materials

Raw materials

1-BOC-4-CBZ-AMINO-PIPERIDINE Hydrochloric acid Water Methanol

Preparation Products

1-ISOPROPYL-PIPERIDIN-4-YLAMINE 4-(Cbz-aMino)-1-(Methylsulfonyl)piperidine

4-Cbz-Aminopiperidine Suppliers

Global( 117)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Changzhou Ditong Chemical Co.,Ltd 		+86-0519-88298848 info@edengenechem.com China 2165 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Hubei Ipure Biology Co., Ltd 		+8613367258412 ada@ipurechemical.com China 10236 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Changzhou Ditong Chemical Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Hubei Ipure Biology Co., Ltd 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 4-Cbz-Aminopiperidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-CBZ-piperidin-4-aMine pictures 2021-07-02 N-CBZ-piperidin-4-aMine
182223-54-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-Cbz-Aminopiperidine pictures 2019-07-06 4-Cbz-Aminopiperidine
182223-54-7
 $1.00 1KG 98% 100KG Career Henan Chemical Co

4-Cbz-Aminopiperidine Spectrum

4-Cbz-Aminopiperidine(182223-54-7)1HNMR

182223-54-7(4-Cbz-Aminopiperidine)Related Search:

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Benzyloxyacetyl chloride Nequinate 1-BOC-4-CBZ-AMINO-PIPERIDINE Piperidine 3-CBZ-AMINOPIPERIDINE,3-CBZ-AMINOPIPERIDINE HCL,3-N-Cbz-aminopiperidine hydrochloride
1-Piperidinecarboxylic acid, 3-[[(phenylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, (3R)- 1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID 4-BENZYLOXY-CARBONYL-AMINO-1-N-BUTOXY-CARBONYL-4-METHYL PIPERIDINE METHYL-(1-METHYL-4-PYRROLIDIN-1-YLMETHYL-PIPERIDIN-4-YL)-CARBAMIC ACID BENZYL ESTER L371,257
4-BENZYLOXYCARBONYLAMINO-4-METHYL-PIPERIDINE 4-Cbz-Aminopiperidine (4r,5s)-4-methyl-5-phenyl-3-piperidin-4-yl-1,3-oxazolidin-2-one hydrochloride

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Carbamic acid, 4-piperidinyl-, phenylmethyl ester benzyl piperidin-4-ylcarbamate hydrochloride N-CBZ-piperidin-4-aMine benzyl N-(piperidin-4-yl)carbaMate 4-Benzyloxycarbonylamino-piperdine 4-CBZ-AMINOPIPERIDINE 4-BENZYLOXYCARBONYLAMINO-PIPERIDINE Carbamic acid, 4-piperidinyl-, phenylmethyl ester (9CI) Benzylpiperidin-4-ylcarbamate Carbamic acid, N-4-piperidinyl-, phenylmethyl ester 4-(Z-amino)-piperidine Benzyl 4-Piperidinylcarbamate Phenylmethyl N-4-piperidinylcarbamate 182223-54-7 pharmacetical API intermediates N-CBZ