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4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester structure

CAS No.: 288154-16-5

Chemical Name:: 4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester

Synonyms: Z-PIP(BOC)-OH;1-BOC-4-N-CBZ-AMINOISONIPECOTIC ACID;1-Boc-4-N-Cbz-aminoisonipecotic acid, 98%;Z-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID;Cbz-4-amino-1-Boc-piperidine-4-carboxylic acid;1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID;1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid;CBZ-4-Amino-1-Boc-Piperadine-4- Carboxylic acid;4-(Cbz-aMino)-1-Boc-piperidine-4-carboxylic acid;1-N-BOC-4-N-CBZ-AMINO-PIPERIDINE-4-CARBOXYLIC ACID

CBNumber:: CB5277311

Molecular Formula:: C19H26N2O6

Molecular Weight:: 378.42

MDL Number:: MFCD02683056

MOL File:: 288154-16-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:27

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4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Properties

Boiling point	556.1±50.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	3.84±0.20(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	288154-16-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	36/37/38
Safety Statements	26-36/37/39
HS Code	29333990

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	261315	Z-4-amino-1-Boc-piperidine-4-carboxylic acid Asreported	288154-16-5	250mg	$393	2026-06-03	Buy
Usbiological	261315	Z-4-amino-1-Boc-piperidine-4-carboxylic acid Asreported	288154-16-5	500mg	$602	2026-06-03	Buy
Usbiological	261315	Z-4-amino-1-Boc-piperidine-4-carboxylic acid Asreported	288154-16-5	1g	$852	2026-06-03	Buy
Usbiological	242620	Z-4-amino-1-Boc-piperidine-4-carboxylic acid ≥97% (HPLC) ≥97%(HPLC)	288154-16-5	250mg	$237	2026-06-03	Buy
Usbiological	242620	Z-4-amino-1-Boc-piperidine-4-carboxylic acid ≥97% (HPLC) ≥97%(HPLC)	288154-16-5	1g	$390	2026-06-03	Buy

Product number	Packaging	Price	Buy
261315	250mg	$393	Buy
261315	500mg	$602	Buy
261315	1g	$852	Buy
242620	250mg	$237	Buy
242620	1g	$390	Buy

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Chemical Properties, Uses, Production

Chemical Properties

White powder

Synthesis

501-53-1

1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN

183673-68-9

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

288154-16-5

To a solution of compound 2-c (0.50 g, 2.05 mmol) in tetrahydrofuran (THF, 4 mL) was added an aqueous sodium hydroxide solution (0.17 g, 4.30 mmol, 2.10 equiv, 4 mL). The reaction mixture was cooled to 0°C. Benzyl chloroformate (0.32 mL, 2.25 mmol, 1.10 eq.) was slowly added dropwise followed by stirring at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was washed with ether, then the pH of the aqueous layer was adjusted to 2.5 with 1N hydrochloric acid and extracted with ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 4-benzyloxycarbonylaminopiperidine-1,4-dicarboxylic acid mono-tert-butyl ester as a white solid (0.55 g, 71% yield), which was used directly in the next step of the reaction.1H-NMR (CDCl3) δ: 7.29-7.39 (m, 5H), 5.10 (s, 2H), 3.84 (bs, 2H). 3.05-3.15 (m, 2H), 1.95-2.12 (m, 4H), 1.45 (s, 9H).

References

[1] Patent: US2010/168421, 2010, A1. Location in patent: Page/Page column 7
[2] Patent: WO2008/150089, 2008, A1. Location in patent: Page/Page column 15

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Preparation Products And Raw materials

Raw materials

Benzyl chloroformate 1-t-Boc-piperidine-4-spiro-5'-[1',3'-bis-t-Boc]-hydantoin Tetrahydrofuran Sodium hydroxide Water

Hydrochloric acid

1of2

Preparation Products

tert-butyl 4-(benzyloxycarbonylamino)-4-carbamoylpiperidine-1-carboxylate

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Suppliers

Global Suppliers ( 90)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16306	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Shanghai Feibo Chemical Technology Co., Ltd	021-58955608,2250286 15921236618	blinkzeng@gmail.com	China	522	62
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Shanghai Raise Chemical Technology Co.,Ltd	+86-021-50935922		China	7854	55
Tianjin Chempharmatech Co.,Ltd.	022-66211079 13212288319	sales@chempharmatech.com	China	944	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Wuhan Chemwish Technology Co., Ltd	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Accela ChemBio Co.,Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Chemsky（shanghai）International Co.,Ltd.	50
Shanghai Feibo Chemical Technology Co., Ltd	62
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Shanghai Raise Chemical Technology Co.,Ltd	55
Tianjin Chempharmatech Co.,Ltd.	55

View Latest Price from 4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 288154-16-5	$31.00-81.00		99.72%	10g	TargetMol Chemicals Inc.
	2020-02-19	4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 288154-16-5	$3.00	1KG	98%	200KG	Career Henan Chemical Co

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
288154-16-5
$31.00-81.00
99.72%
TargetMol Chemicals Inc.

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
288154-16-5
$3.00
98%
Career Henan Chemical Co

4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester Spectrum

4-BENZYLOXYCARBONYLAMINO-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER(288154-16-5)¹HNMR

288154-16-5 (4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester) Related Search:

4-Amino-1-Boc-piperidine-4-carboxylic acid 1-Boc-piperidine Ethyl 4-hydroxypiperidine-1-carboxylate 4-Cbz-Aminopiperidine 1-Boc-4-Methylaminopiperidine

4-Amino-1-Boc-piperidine Isopropyl 4-aminopiperidine-1-carboxylate 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-alpha-Cbz-L-2,4-diamiobutyric acid N-Boc-4-piperidinemethanol

1-Boc-4-Cbz-amino-piperidine N-Boc-isonipecotic acid Z-Aib-OH Z-Dab(Boc)-OH 4-Amino-1-methyl-4-piperidinecarboxylic acid

H-D-Dab(Boc)-OH (S)-3-Cbz-amino-butylamine 4-Amino-1-n-butoxycarbonyl-4-methyl-piperidine

1of4

Z-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID Z-PIP(BOC)-OH 1-N-BOC-4-N-CBZ-AMINO-PIPERIDINE-4-CARBOXYLIC ACID 4-(BENZYLOXYCARBONYLAMINO)-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-4-CARBOXYLIC ACID 1-BOC-4-N-CBZ-AMINOPIPERIDINE-4-CARBOXYLIC ACID 1,4-Piperidinedicarboxylic acid, 4-[[(phenylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester N-BOC-4-(N-CBZ-AMINO) PIPERIDINE-4-CARBOXYLIC ACID 1-Boc-4-(Cbz-amino)piperidine-4-carboxylic Acid 1-BOC-4-N-CBZ-AMINOISONIPECOTIC ACID 4-(Cbz-aMino)-1-Boc-piperidine-4-carboxylic acid Cbz-4-amino-1-Boc-piperidine-4-carboxylic acid 4-[(Benzyloxycarbonyl)amino]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 1-[(2-methylpropan-2-yl)oxycarbonyl]-4-(phenylmethoxycarbonylamino)piperidine-4-carboxylic Acid 1-(1,1-Dimethylethyl) 4-[[(phenylmethoxy)carbonyl]amino]-1,4-piperidinedicarboxylate CBZ-4-Amino-1-Boc-Piperadine-4- Carboxylic acid 1-Boc-4-N-Cbz-aminoisonipecotic acid, 98% 4-benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, 10 mM in DMSO 1-(tert-Butyl) 4-(N-CBZ-amino)-1,4-piperidinedicarboxylate 4-Benzyloxycarbonylamino-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 288154-16-5 C19H26N2O6