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3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Structure
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine structure
CAS No.
111669-25-1
Chemical Name:
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
Synonyms
BUTTPARK 46\04-67;Palbociclib Impurity 169;1-Boc-4-(3-Aminopyridin-2-yl);2-(4-Boc-1-piperazinyl)pyridin-3-amine;1-Boc-4-(3-aMinopyridin-2-yl)piperazine;3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE;butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate;3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine;tert-butyl 4-(3-amino-2-pyridyl)piperazine-1-carboxylate;ert-butyl4-(3-aminopyridin-2-yl)piperazine-1-carboxylate
CBNumber:
CB7852848
Molecular Formula:
C14H22N4O2
Molecular Weight:
278.35
MDL Number:
MFCD03407996
MOL File:
111669-25-1.mol
MSDS File:
SDS
Last updated:2026-05-28 02:41:36
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3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Properties

Boiling point 448.8±45.0 °C(Predicted)
Density 1.182±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 9.35±0.29(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  45-37-26
HS Code  29339900

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 074584 1-Boc-4-(3-Aminopyridin-2-yl)piperazine 111669-25-1 1.00g $66 2026-05-18 Buy
Matrix Scientific 074584 1-Boc-4-(3-Aminopyridin-2-yl)piperazine 111669-25-1 5.00g $201 2026-05-18 Buy
Matrix Scientific 074584 1-Boc-4-(3-Aminopyridin-2-yl)piperazine 111669-25-1 10.00g $311 2026-05-18 Buy
Synthonix A37463 1-Boc-4-(3-Aminopyridin-2-yl)piperazine 90+% 111669-25-1 100mg $100 2026-05-06 Buy
Synthonix A37463 1-Boc-4-(3-Aminopyridin-2-yl)piperazine 90+% 111669-25-1 250mg $120 2026-05-06 Buy
Product number Packaging Price Buy
074584 1.00g $66 Buy
074584 5.00g $201 Buy
074584 10.00g $311 Buy
A37463 100mg $100 Buy
A37463 250mg $120 Buy

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Chemical Properties, Uses, Production

Chemical Properties

Grey to purple powder

Synthesis

4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

153473-24-6

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine

111669-25-1

Tert-butyl 4-(3-nitropyridin-2-yl)piperazine-1-carboxylate (350 mg, 1.14 mmol) was used as a raw material and mixed with Pd/C (60.4 mg, 10% w/w, 0.0568 mmol) and methanol (6 mL). The hydrogenation reaction was carried out at room temperature using a hydrogen balloon to provide a hydrogen atmosphere. The reaction mixture was stirred for 2 h and then filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (eluent ratio hexane/EtOAc/CH2Cl2 = 1:1:1) to afford the target product tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate (246 mg, 78% yield) as a white powder. Mass spectrometry (EI) analysis resulted in a molecular ion peak (MH+) of 279.2 for C14H22N4O2.

References

[1] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 999 - 1014
[2] Patent: WO2012/61337, 2012, A1. Location in patent: Page/Page column 45
[3] Patent: WO2008/112440, 2008, A1. Location in patent: Page/Page column 38-39
[4] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 11, p. 1406 - 1411
[5] Journal of Labelled Compounds and Radiopharmaceuticals, 2011, vol. 54, # 7, p. 363 - 366

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Preparation Products And Raw materials

Raw materials

Ethanol Di-tert-butyl dicarbonate Piperazine Palladium Ethyl acetate
Hydrogen Dichloromethane Methanol 2-Chloro-3-nitropyridine Citric acid

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Preparation Products

3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine Suppliers

Global Suppliers ( 63)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Chengdu Research Accelerators Technology Co., Ltd. 028-64353063 reacchemical@163.com China 5243 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Pure Chemistry Scientific Inc. 62
Shanghai Topbiochem Technology Co., Ltd 58
9ding chemical ( Shanghai) Limited 56
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Chengdu Research Accelerators Technology Co., Ltd. 58

View Latest Price from 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine pictures 2020-01-01 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
111669-25-1
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co

111669-25-1 (3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine) Related Search:

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3-Amino-4-methoxypyridine 2-Chloro-5-iodo-pyridin-3-ylamine 1-Boc-4-(3-amino-4-pyridinyl)-piperazine

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4-(3-amino-2-pyridinyl)-1-piperazinecarboxylic acid butyl ester 3-AMINO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE BUTTPARK 46\04-67 1-(TERT-BUTYLOXYCARBONYL)-4-(3-AMINOPYRIDIN-2-YL)PIPERAZINE tert-butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate 3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine ,97% 3-Amino-2-[4-tert-butoxycarbonyl(piperazino)]pyridine 1-Boc-4-(3-aMinopyridin-2-yl)piperazine butyl 4-(3-aminopyridin-2-yl)piperazine-1-carboxylate 1-Boc-4-(3-Aminopyridin-2-yl) 1-Piperazinecarboxylic acid, 4-(3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester tert-butyl 4-(3-amino-2-pyridyl)piperazine-1-carboxylate ert-butyl4-(3-aminopyridin-2-yl)piperazine-1-carboxylate 2-(4-Boc-1-piperazinyl)pyridin-3-amine Palbociclib Impurity 169 111669-25-1 Heterocycle-Pyridine series pharmacetical Amines Pyridines