5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
- CAS No.
- 871254-61-4
- Chemical Name:
- 5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
- Synonyms
- 2,4-DichloropyriMidine-5-...;2,4-Dichloro-5-pyrimidinecarbaldehyde;2,4-Dichloropyrimidine-5-Carboxaldehyde;2,4-Dichloro-5-pyriMidinecarboxaldehyde;5-Pyrimidinecarboxaldehyde, 2,4-dichloro-;2,4-dichloropyrimidine-5-carbaldehyde oxime;5-Pyrimidinecarboxaldehyde, 2,4-dichloro- ISO 9001：2015 REACH
- CBNumber:
- CB62130141
- Molecular Formula:
- C5H2Cl2N2O
- Molecular Weight:
- 176.99
- MDL Number:
- MFCD11112096
- MOL File:
- 871254-61-4.mol
- MSDS File:
- SDS
| Boiling point | 294.0±20.0 °C(Predicted) |
|---|---|
| Density | 1.588±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -4.44±0.29(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C5H2Cl2N2O/c6-4-3(2-10)1-8-5(7)9-4/h1-2H |
| InChIKey | MTIXQNKVUJSOQH-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(C=O)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS17185 | 2,4-Dichloropyrimidine-5-carbaldehyde 97% | 871254-61-4 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS17185 | 2,4-Dichloropyrimidine-5-carbaldehyde 97% | 871254-61-4 | 5g | $108 | 2026-06-04 | Buy |
| Activate Scientific | AS17185 | 2,4-Dichloropyrimidine-5-carbaldehyde 97% | 871254-61-4 | 25g | $401 | 2026-06-04 | Buy |
| Synthonix | D8019 | 2,4-Dichloropyrimidine-5-carbaldehyde 97.0% | 871254-61-4 | 1g | $30 | 2026-05-06 | Buy |
| Synthonix | D8019 | 2,4-Dichloropyrimidine-5-carbaldehyde 97.0% | 871254-61-4 | 5g | $70 | 2026-05-06 | Buy |
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- Chemical Properties, Uses, Production
Uses
2,4-Dichloro-5-pyrimidinecarboxaldehyde, is an organic building block used for the synthesis of novel pyrazolo[3,4-d]pyrimidine compounds, as possible kinase inhibitors.
Synthesis
4394-85-8
36082-50-5
871254-61-4
General procedure for the preparation of 2,4-dichloropyrimidine-5-carbaldehyde: In a 2L round-bottomed flask, a solution of isopropylmagnesium chloride lithium chloride complex in THF (2M, 184mL, 368mmol) was added dropwise to a solution of 5-bromo-2,4-dichloropyrimidine (49.6g, 218mmol) in THF (1000mL) over a period of ~30 minutes at ~-78 °C (1000 mL). The reaction mixture was stirred at about -78 °C for about 30 minutes. Subsequently, morpholine-4-carbaldehyde (75.0 g, 653 mmol) was added dropwise over about 30 minutes at the same temperature. After continuing to stir at about -78°C for about 30 minutes, the reaction mixture was slowly warmed to about -35°C and stirred at this temperature for about 30 minutes. Upon completion of the reaction, 1N HCl aqueous solution (250 mL) and ether (500 mL) were added and the mixture was then warmed to room temperature. The organic layer was separated and the aqueous layer was further extracted with ether (200 mL). The combined organic layers were dried with anhydrous MgSO4, filtered through a silica gel pad and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using dichloromethane (100%) as eluent to afford 2,4-dichloropyrimidine-5-carbaldehyde (27.3 g, 71% yield) as a light yellow solid.1H NMR (400 MHz, CDCl3) δ 10.34 (s, 1H), 9.30 (s, 1H).
References
[1] Patent: WO2011/156698, 2011, A2. Location in patent: Page/Page column 52
5-Pyrimidinecarboxaldehyde, 2,4-dichloro- Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Titan Enterprise Development Co., Ltd | 16621224781 | syy@titansci.com | China | 2893 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
View Latest Price from 5-Pyrimidinecarboxaldehyde, 2,4-dichloro- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2,4-dichloropyrimidine-5-carbaldehyde
871254-61-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-09-05 | 5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
871254-61-4
|
$6.00 | 1KG | 95%-98% | 100 | Career Henan Chemical Co |
-
- 2,4-dichloropyrimidine-5-carbaldehyde
871254-61-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Pyrimidinecarboxaldehyde, 2,4-dichloro-
871254-61-4
- $6.00
- 95%-98%
- Career Henan Chemical Co
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