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2-Chloro-5-nitropyridin-4-amine

2-Chloro-5-nitropyridin-4-amine Structure
2-Chloro-5-nitropyridin-4-amine structure
CAS No.
2604-39-9
Chemical Name:
2-Chloro-5-nitropyridin-4-amine
Synonyms
2-Chloro-5-nitropyridin-4-amine;2-Chloro-4-aMino-5-nitropyridine;4-Pyridinamine,2-chloro-5-nitro-;4-Amino-2-chloro-5-nitro-pyridine;2-Chloro-5-nitro-pyridin-4-ylamine;4-Amino-2-chloro-5-nitropyridine 98%;2-chloro-5-nitropyridin-4-amine, 98%min;2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH
CBNumber:
CB81010059
Molecular Formula:
C5H4ClN3O2
Molecular Weight:
173.56
MDL Number:
MFCD09033797
MOL File:
2604-39-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:45:34
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2-Chloro-5-nitropyridin-4-amine Properties

Melting point 155-156 °C
Boiling point 388.5±37.0 °C(Predicted)
Density 1.596±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form solid
pka 0.63±0.42(Predicted)
color Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
HS Code  2933399990

2-Chloro-5-nitropyridin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech CL0272 2-CHLORO-5-NITROPYRIDIN-4-AMINE 97% 2604-39-9 1G $27 2026-04-30 Buy
AstaTech CL0272 2-CHLORO-5-NITROPYRIDIN-4-AMINE 97% 2604-39-9 5G $139 2026-04-30 Buy
AstaTech CL0272 2-CHLORO-5-NITROPYRIDIN-4-AMINE 97% 2604-39-9 25G $477 2026-04-30 Buy
Apolloscientific OR15938 4-Amino-2-chloro-5-nitropyridine 97% 2604-39-9 100mg $21 2026-06-04 Buy
Apolloscientific OR15938 4-Amino-2-chloro-5-nitropyridine 97% 2604-39-9 1g $24 2026-06-04 Buy
Product number Packaging Price Buy
CL0272 1G $27 Buy
CL0272 5G $139 Buy
CL0272 25G $477 Buy
OR15938 100mg $21 Buy
OR15938 1g $24 Buy

2-Chloro-5-nitropyridin-4-amine Chemical Properties,Uses,Production

Uses

2-Chloro-4-amino-5-nitropyridine is an intermediate of benzimidazole derivatives used to treat diseases such as bone development disorders; it is also an intermediate of a PLK1 recombinant protein inhibitor used to treat cell proliferation disorders, especially cancer.

Chemical Properties

white to light yellow crystal powder

Synthesis

2-CHLORO-4-N-NITRO(AMINOPYRIDINE)

14432-13-4

2-Chloro-5-nitropyridin-4-amine

2604-39-9

4-Amino-2-chloro-3-nitropyridine

2789-25-5

2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was carefully dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction at 100 °C for 1 h. The reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under ice bath conditions, ensuring that the temperature was maintained below 20 °C. Subsequently, the resulting yellow solid was separated and the aqueous layer was extracted with ethyl acetate (200 mL × 3). The organic layers were combined, concentrated, and the residue was purified by silica gel column chromatography (eluent ratio: hexane:EtOAc = 4:1 to pure EtOAc, v/v) to give 6.0 g of 4-amino-2-chloro-3-nitropyridine in 70% yield and 2.0 g of 4-amino-2-chloro-5-nitropyridine in 25% yield. The properties of 4-amino-2-chloro-3-nitropyridine were as follows: melting point 179-181 °C; UV(H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 1.0 g 4-amino-2-chloro-5-nitropyridine, yield 25%. 1H); 13C-NMR (DMSO, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. The 1H-NMR (DMSO, 500 MHz) data of 4-amino-2-chloro-5-nitropyridine were as follows: δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H).

References

[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545

2-Chloro-5-nitropyridin-4-amine Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine Ammonium hydroxide Ethyl acetate Nitric acid Petroleum ether
Sulfuric acid 2-Chloro-5-nitropyridine 2-Chloro-4-N-nitro(aminopyridine) 2,4-Dichloro-5-nitropyridine 2-Amino-6-chloro-3-nitropyridine

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Preparation Products

2-Chloro-5-nitropyridine 2-Amino-5-nitropyridine 6-Chloro-3,4-pyridinediamine tert-butyl 2-chloro-5-nitropyridin-4-ylcarbamate

2-Chloro-5-nitropyridin-4-amine Suppliers

Global( 188)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiaxing Rich Biological Technology Co., Ltd. 0573-11111111-1111 18969316891 richmol@163.com China 445 50
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Supplier Advantage
Jiaxing Rich Biological Technology Co., Ltd. 50
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50

View Lastest Price from 2-Chloro-5-nitropyridin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-nitropyridin-4-amine pictures 2026-08-25 2-Chloro-5-nitropyridin-4-amine
2604-39-9
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2-Chloro-5-nitropyridin-4-amine pictures 2026-08-20 2-Chloro-5-nitropyridin-4-amine
2604-39-9
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloro-5-nitropyridin-4-amine pictures 2019-08-09 2-Chloro-5-nitropyridin-4-amine
2604-39-9
 $8.80 1KG 97%-99% 100kg Career Henan Chemical Co

2-Chloro-5-nitropyridin-4-amine Spectrum

2-Chloro-5-nitropyridin-4-amine(2604-39-9)1HNMR

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4-Amino-2-chloro-5-nitro-pyridine 2-Chloro-5-nitropyridin-4-amine 2-Chloro-4-aMino-5-nitropyridine 2-Chloro-5-nitro-pyridin-4-ylamine 4-Pyridinamine,2-chloro-5-nitro- 4-Amino-2-chloro-5-nitropyridine 98% 2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH 2-chloro-5-nitropyridin-4-amine, 98%min 2604-39-9 Heterocycle-Pyridine series Pyridine