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2-Chloro-5-nitropyridin-4-amine

2-Chloro-5-nitropyridin-4-amine structure

CAS No.: 2604-39-9

Chemical Name:: 2-Chloro-5-nitropyridin-4-amine

Synonyms: 2-Chloro-5-nitropyridin-4-amine;2-Chloro-4-aMino-5-nitropyridine;4-Pyridinamine,2-chloro-5-nitro-;4-Amino-2-chloro-5-nitro-pyridine;2-Chloro-5-nitro-pyridin-4-ylamine;4-Amino-2-chloro-5-nitropyridine 98%;2-chloro-5-nitropyridin-4-amine, 98%min;2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH

CBNumber:: CB81010059

Molecular Formula:: C5H4ClN3O2

Molecular Weight:: 173.56

MDL Number:: MFCD09033797

MOL File:: 2604-39-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:35

Product description	Number	Pack Size	Price
2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	CL0272	1G	$27
2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	CL0272	5G	$139
2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	CL0272	25G	$477
4-Amino-2-chloro-5-nitro pyridine ≥98%(HPLC)	29152	1G	$51.18
4-Amino-2-chloro-5-nitro pyridine ≥98%(HPLC)	29152	5G	$221.63
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2-Chloro-5-nitropyridin-4-amine Properties

Melting point	155-156 °C
Boiling point	388.5±37.0 °C(Predicted)
Density	1.596±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	0.63±0.42(Predicted)
form	solid
color	Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xn
HS Code	2933399990

2-Chloro-5-nitropyridin-4-amine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	CL0272	2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	2604-39-9	1G	$27	2026-04-30	Buy
AstaTech	CL0272	2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	2604-39-9	5G	$139	2026-04-30	Buy
AstaTech	CL0272	2-CHLORO-5-NITROPYRIDIN-4-AMINE 97%	2604-39-9	25G	$477	2026-04-30	Buy
Chem-Impex	29152	4-Amino-2-chloro-5-nitro pyridine ≥98%(HPLC)	2604-39-9	1G	$51.18	2026-05-19	Buy
Chem-Impex	29152	4-Amino-2-chloro-5-nitro pyridine ≥98%(HPLC)	2604-39-9	5G	$221.63	2026-05-19	Buy

Product number	Packaging	Price	Buy
CL0272	1G	$27	Buy
CL0272	5G	$139	Buy
CL0272	25G	$477	Buy
29152	1G	$51.18	Buy
29152	5G	$221.63	Buy

2-Chloro-5-nitropyridin-4-amine Chemical Properties,Uses,Production

Uses

2-Chloro-4-amino-5-nitropyridine is an intermediate of benzimidazole derivatives used to treat diseases such as bone development disorders; it is also an intermediate of a PLK1 recombinant protein inhibitor used to treat cell proliferation disorders, especially cancer.

Chemical Properties

white to light yellow crystal powder

Synthesis

14432-13-4

2604-39-9

2789-25-5

2-Chloro-4-nitroaminopyridine (CAS: 14432-13-4, 10.0 g) was used as a raw material, which was carefully dissolved in 100 mL of concentrated sulfuric acid at room temperature, followed by heating the reaction at 100 °C for 1 h. The reaction was carried out at room temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into 250 g of crushed ice. The pH of the mixture was adjusted to 3 with concentrated ammonium hydroxide under ice bath conditions, ensuring that the temperature was maintained below 20 °C. Subsequently, the resulting yellow solid was separated and the aqueous layer was extracted with ethyl acetate (200 mL × 3). The organic layers were combined, concentrated, and the residue was purified by silica gel column chromatography (eluent ratio: hexane:EtOAc = 4:1 to pure EtOAc, v/v) to give 6.0 g of 4-amino-2-chloro-3-nitropyridine in 70% yield and 2.0 g of 4-amino-2-chloro-5-nitropyridine in 25% yield. The properties of 4-amino-2-chloro-3-nitropyridine were as follows: melting point 179-181 °C; UV(H2O) λmax 238.0 nm (ε 13586, pH 11); 1H-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 13C-NMR (DMSO, 500 MHz) δ 7.91 (d, J = 6.0 Hz, 1H), 7.37 (s, 2H), 6.83 (d, J = 6.0 Hz, 1H); 1.0 g 4-amino-2-chloro-5-nitropyridine, yield 25%. 1H); 13C-NMR (DMSO, 125 MHz) δ 149.54, 149.24, 142.69, 142.33, 122.45. The 1H-NMR (DMSO, 500 MHz) data of 4-amino-2-chloro-5-nitropyridine were as follows: δ 8.85 (s, 1H), 7.37 (s, 2H), 6.96 (s, 1H).

References

[1] Patent: WO2007/47793, 2007, A2. Location in patent: Page/Page column 87
[2] Roczniki Chemii, 1956, vol. 30, p. 1139,1144
[3] Chem.Abstr., 1957, p. 12089
[4] Nucleosides, nucleotides and nucleic acids, 2004, vol. 23, # 1-2, p. 67 - 76
[5] Organic and Biomolecular Chemistry, 2013, vol. 11, # 38, p. 6526 - 6545

2-Chloro-5-nitropyridin-4-amine Preparation Products And Raw materials

Raw materials

4-Amino-2-chloropyridine Ammonium hydroxide Ethyl acetate Nitric acid Petroleum ether

Sulfuric acid 2-Chloro-5-nitropyridine 2-CHLORO-4-N-NITRO(AMINOPYRIDINE) 2,4-DICHLORO-5-NITROPYRIDINE 2-Amino-6-chloro-3-nitropyridine

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Preparation Products

2-Chloro-5-nitropyridine 2-Amino-5-nitropyridine 6-CHLORO-3,4-PYRIDINEDIAMINE tert-butyl 2-chloro-5-nitropyridin-4-ylcarbamate

2-Chloro-5-nitropyridin-4-amine Suppliers

Global( 190)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Shandong chuangyingchemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 2-Chloro-5-nitropyridin-4-amine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	2-Chloro-5-nitropyridin-4-amine 2604-39-9	US $3.00-9.00 / KG	0.1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-11-18	2-Chloro-5-nitropyridin-4-amine 2604-39-9	US $1.10 / g	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2019-08-09	2-Chloro-5-nitropyridin-4-amine 2604-39-9	US $8.80 / KG	1KG	97%-99%	100kg	Career Henan Chemical Co

2-Chloro-5-nitropyridin-4-amine
2604-39-9
US $3.00-9.00 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2-Chloro-5-nitropyridin-4-amine
2604-39-9
US $1.10 / g
99.00%
Dideu Industries Group Limited

2-Chloro-5-nitropyridin-4-amine
2604-39-9
US $8.80 / KG
97%-99%
Career Henan Chemical Co

2-Chloro-5-nitropyridin-4-amine Spectrum

2-Chloro-5-nitropyridin-4-amine(2604-39-9)¹HNMR

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4-Amino-2-chloro-5-nitro-pyridine 2-Chloro-5-nitropyridin-4-amine 2-Chloro-4-aMino-5-nitropyridine 2-Chloro-5-nitro-pyridin-4-ylamine 4-Pyridinamine,2-chloro-5-nitro- 4-Amino-2-chloro-5-nitropyridine 98% 2-Chloro-5-nitropyridin-4-amine ISO 9001：2015 REACH 2-chloro-5-nitropyridin-4-amine, 98%min 2604-39-9 Heterocycle-Pyridine series Pyridine