Tetrahydrothiopyran-4-one
- CAS No.
- 1072-72-6
- Chemical Name:
- Tetrahydrothiopyran-4-one
- Synonyms
- TETRAHYDRO-4H-THIOPYRAN-4-ONE;dihydro-2H-thiopyran-4(3H)-one;THIAN-4-ONE;4H-Thiopyran-4-one, tetrahydro-;Penthianone;4-OXOTHIANE;4-Oxothiane>THIAN-3-ONEOXIME;4-Thiacyclohexanon;4-thiacyclohexanone
- CBNumber:
- CB8202200
- Molecular Formula:
- C5H8OS
- Molecular Weight:
- 116.18
- MDL Number:
- MFCD00006660
- MOL File:
- 1072-72-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Tetrahydro-4H-thiopyran-4-one 99% | 155160 | 1g | $47.5 |
| Tetrahydro-4H-thiopyran-4-one 99% | 155160 | 5g | $128 |
| 4-Oxothiane >98.0%(GC) | O0112 | 5g | $61 |
| 4-Oxothiane >98.0%(GC) | O0112 | 25g | $196 |
| Tetrahydro-2H-thiopyran-4-one Asreported | 290792 | 5g | $418 |
| More product size | |||
| Melting point | 60-64 °C (lit.) |
|---|---|
| Boiling point | 140.82°C (estimate) |
| Density | 1.050 (estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly) |
| form | Crystalline Solid |
| color | White to pale yellow |
| BRN | 106464 |
| InChI | InChI=1S/C5H8OS/c6-5-1-3-7-4-2-5/h1-4H2 |
| InChIKey | OVRJVKCZJCNSOW-UHFFFAOYSA-N |
| SMILES | C1SCCC(=O)C1 |
| LogP | 0.490 (est) |
| CAS DataBase Reference | 1072-72-6(CAS DataBase Reference) |
| FDA UNII | 667X5M356L |
| NIST Chemistry Reference | 4H-Thiopyran-4-one, tetrahydro-(1072-72-6) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280i-P305+P351+P338-P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Tetrahydrothiopyran-4-one price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 155160 | Tetrahydro-4H-thiopyran-4-one 99% | 1072-72-6 | 1g | $47.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 155160 | Tetrahydro-4H-thiopyran-4-one 99% | 1072-72-6 | 5g | $128 | 2023-06-20 | Buy |
| TCI Chemical | O0112 | 4-Oxothiane >98.0%(GC) | 1072-72-6 | 5g | $61 | 2026-04-30 | Buy |
| TCI Chemical | O0112 | 4-Oxothiane >98.0%(GC) | 1072-72-6 | 25g | $196 | 2026-04-30 | Buy |
| Usbiological | 290792 | Tetrahydro-2H-thiopyran-4-one Asreported | 1072-72-6 | 5g | $418 | 2026-06-03 | Buy |
Tetrahydrothiopyran-4-one Chemical Properties,Uses,Production
Chemical Properties
WHITE TO PALE YELLOW CRYSTALLINE SOLID
Uses
Tetrahydro-4H-thiopyran-4-one is a cyclic carbonyl compound used as a reactant in the stereoselective preparation of [aryl(nitro)ethyl] carbonyl compounds via asymmetric Michael addition to nitroolefins catalyzed by chiral pyrrolidine-pyridine conjugate bases.
General Description
The diastereoselectivity of the aldol reaction of tetrahydro-4H-thiopyran-4-one has been studied.
Purification Methods
Purify it by recrystallisation from diisopropyl ether or pet ether and dry it in air. If too impure, then dissolve it in Et2O, wash with aqueous NaHCO3, then H2O, dry (MgSO4), filter, evaporate and the residue is recrystallised as before. [Cardwell J Chem Soc 715 1949.] The oxime can be recrystallised from CHCl3/pet ether (at -20o) and has m 84-85o [Barkenbus et al. J Org Chem 20 871 1955]. The 2,4-dinitrophenylhydrazone has m 186o (from EtOAc) [Barkenbus et al. J Org Chem 16 232 1951]. The S-dioxide is recrystallised from AcOH, m 173-174o [Fehnel & Carmack J Am Chem Soc 70 1813 1948, Beilstein 17 II 287, 17 III/IV 4172, 17/1 V 21].
Tetrahydrothiopyran-4-one Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Liyang Kunlun Biological Technology Co., Ltd. | +86-13813530041 | z13813530041@126.com | China | 337 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
View Lastest Price from Tetrahydrothiopyran-4-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 4-Thiacyclohexanon
1072-72-6
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-11-18 | Tetrahydrothiopyran-4-one
1072-72-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | Tetrahydrothiopyran-4-one
1072-72-6
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 4-Thiacyclohexanon
1072-72-6
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Tetrahydrothiopyran-4-one
1072-72-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Tetrahydrothiopyran-4-one
1072-72-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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