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2,2-Difluoroethanol

2,2-Difluoroethanol structure

CAS No.: 359-13-7

Chemical Name:: 2,2-Difluoroethanol

Synonyms: 2,2-difluoroethan-1-ol;CHF2CH2OH;Ethanol, 2,2-difluoro-;DK755;AKOS B019710;Difluoroalcohol;2,2-DIFLUOROETHANOL;ART-CHEM-BB B019710;2,3-Difluoroethanol;2,2-Difluoroalcohol

CBNumber:: CB8211291

Molecular Formula:: C2H4F2O

Molecular Weight:: 82.05

MDL Number:: MFCD00042248

MOL File:: 359-13-7.mol

MSDS File:: SDS

Last updated:2026-05-28 03:40:50

Product description	Number	Pack Size	Price
2,2-Difluoroethanol >98.0%(GC)	D4128	5g	$23
2,2-Difluoroethanol >98.0%(GC)	D4128	25g	$44
2,2-Difluoroethanol Asreported	271073	10g	$319
2,2-Difluoroethanol Asreported	271073	25g	$446
2,2-Difluoroethanol Asreported	271073	50g	$602
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2,2-Difluoroethanol Properties

Melting point	-28°C
Boiling point	95 °C
Density	1.296
refractive index	1.338
Flash point	3°C
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	soluble in chloroform, ethanol.
pka	13.00±0.10(Predicted)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	1.296
BRN	1731617
Henry's Law Constant	9.3×10^-1 mol/(m³Pa) at 25℃, Burkholder et al. (2019)
CAS DataBase Reference	359-13-7(CAS DataBase Reference)
NIST Chemistry Reference	Difluoroethanol(359-13-7)
EPA Substance Registry System	2,2-Difluoroethanol (359-13-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H315-H319-H335

Precautionary statements

P261-P303+P361+P353-P305+P351+P338-P405-P501a-P210-P233-P240-P241+P242+P243-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P403+P235-P501

Hazard Codes

F,T

Risk Statements

11-20/21/22-36/37/38

Safety Statements

16-36/37/39-45-60-37-33-26-7

RIDADR

1987

Hazard Note

Flammable

HazardClass

PackingGroup

HS Code

29055900

Limited Quantities

1.0 L (0.3 gallon) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	3
2		0

2,2-Difluoroethanol price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4128	2,2-Difluoroethanol >98.0%(GC)	359-13-7	5g	$23	2026-04-30	Buy
TCI Chemical	D4128	2,2-Difluoroethanol >98.0%(GC)	359-13-7	25g	$44	2026-04-30	Buy
Usbiological	271073	2,2-Difluoroethanol Asreported	359-13-7	10g	$319	2026-06-03	Buy
Usbiological	271073	2,2-Difluoroethanol Asreported	359-13-7	25g	$446	2026-06-03	Buy
Usbiological	271073	2,2-Difluoroethanol Asreported	359-13-7	50g	$602	2026-06-03	Buy

Product number	Packaging	Price	Buy
D4128	5g	$23	Buy
D4128	25g	$44	Buy
271073	10g	$319	Buy
271073	25g	$446	Buy
271073	50g	$602	Buy

2,2-Difluoroethanol Chemical Properties,Uses,Production

Chemical Properties

Colorless Liquid

Uses

2,2-Difluoroethanol is used as a chemical intermediates. It has wide applications in medicine and fluoropolymers.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 23, p. 985, 1980 DOI: 10.1021/jm00183a005

Synthesis

1550-44-3

359-13-7

Example 13: Synthesis of 2,2-difluoroethanol from ethyl 2,2-difluoroacetate (Step b2) In a 0.5 L glass reactor equipped with a mechanical stirrer, reflux condenser and temperature probe, 164 g of ethyl 2,2-difluoroacetate (GC purity 95%), 106 g of methanol, and 3 g of solid NaOH were added. the reaction was carried out at 65 °C for 2 h until the conversion was complete. The 2,2-difluoroethanol was isolated by distillation to give 96.3% GC purity and 87% isolated yield.

References

[1] Patent: CN107986944, 2018, A. Location in patent: Paragraph 0020; 0023; 0026; 0029; 0032
[2] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 12
[3] Patent: US2014/243561, 2014, A1. Location in patent: Paragraph 0040; 0041; 0042
[4] Patent: WO2009/40367, 2009, A1. Location in patent: Page/Page column 10
[5] Patent: CN108178723, 2018, A. Location in patent: Paragraph 0015; 0016; 0018; 0020

2,2-Difluoroethanol synthesis

Synthesis of 2,2-Difluoroethanol from Ethyl difluoroacetate

2,2-Difluoroethanol Preparation Products And Raw materials

Raw materials

Difluoroacetaldehyde 2,2-Difluoroethanol 1-formate Ethanol, 2,2-difluoro-1-methoxy- 2,2-Difluoroethyldifluoroacetate Difluoroacetic acid

2-CHLORO-1,1-DIFLUOROETHANE 2,2-Difluoroethyl Acetate Ethyl difluoroacetate DIFLUOROACETALDEHYDE ETHYL HEMIACETAL 2-BROMO-1,1-DIFLUOROETHANE

DIFLUOROACETYL FLUORIDE METHYL DIFLUOROACETATE Chlorodifluoroacetic acid ethyl ester

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Preparation Products

2,2-DIFLUOROETHYL P-TOLUENESULFONATE

2,2-Difluoroethanol Suppliers

Global( 398)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	17259	58
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1203	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5225	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21586	55

Supplier	Advantage
CD Chemical Group Limited	58
Hangzhou Verychem Science And Technology Co.Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 2,2-Difluoroethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	2,2-Difluoroethanol 359-13-7	$10.00	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	2,2-Difluoroethanol 359-13-7	$10.00	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-20	2,2-Difluoroethanol 359-13-7		1kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd

2,2-Difluoroethanol
359-13-7
$10.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

2,2-Difluoroethanol
359-13-7
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2,2-Difluoroethanol
359-13-7
99.99%
Chongqing Soarwin Technology Co., Ltd

2,2-Difluoroethanol Spectrum

2,2-Difluoroethanol(359-13-7)MS 2,2-Difluoroethanol(359-13-7)¹HNMR 2,2-Difluoroethanol(359-13-7)¹³CNMR 2,2-Difluoroethanol(359-13-7)IR1

359-13-7(2,2-Difluoroethanol)Related Search:

CHLORODIFLUOROACETIC ANHYDRIDE Trifluoroacetic anhydride Ethyl trifluoroacetate Methyl pentafluoropropionate TRIMETHYLSILYL TRIFLUOROACETATE

TRIFLUOROACETALDEHYDE ETHYL HEMIACETAL METHYL CHLORODIFLUOROACETATE Heptafluorobutyric anhydride THALLIUM(III) TRIFLUOROACETATE (R)-(-)-2,2,2-TRIFLUORO-1-(9-ANTHRYL)ETHANOL

2,2,2-TRIFLUOROETHYL TRIFLUOROACETATE METHYL HEPTAFLUOROBUTYRATE 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE 2-METHOXY-2-PHENYL-3,3,3-TRIFLUOROPROPIONITRILE ETHYL HEPTAFLUOROBUTYRATE

Methyl trifluoroacetate Perfluoropropionic anhydride 2,2,2-Trifluoroethyl acrylate

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CHF2CH2OH Ethanol, 2,2-difluoro- 2,2-Difluoroethanol,95% 2,2-Difluoroethanol 97% 2,2-Difluoroethanol97% 2,3-Difluoroethanol 1,1-Difluoro-2-hydroxyethane 2,2-Difluoroethan-1-ol 97% ART-CHEM-BB B019710 AKOS B019710 2,2-DIFLUOROETHANOL 2,2-Difluoroethanol> Ethanol, 2,2-difluoro- (6CI,7CI,8CI,9CI) DK755 Difluoroalcohol 2,2-Difluoroalcohol 2,2-difluoroethan-1-ol 359-13-7 359-17-3 HCF2CH2OH C2H4F2O C2H4OF2 Four-membered heterocyclic compound bc0001