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ChemicalBook >> CAS DataBase List >>2,4-difluoro-5-nitropyridine

2,4-difluoro-5-nitropyridine

2,4-difluoro-5-nitropyridine Structure
2,4-difluoro-5-nitropyridine structure
CAS No.
60186-15-4
Chemical Name:
2,4-difluoro-5-nitropyridine
Synonyms
4-difluoro-5-nitropyridine;2,4-difluoro-5-nitropyridine;Pyridine, 2,4-difluoro-5-nitro-
CBNumber:
CB82603364
Molecular Formula:
C5H2F2N2O2
Molecular Weight:
160.08
MDL Number:
MFCD18802741
MOL File:
60186-15-4.mol
MSDS File:
SDS
Last updated:2026-05-28 05:30:18
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2,4-difluoro-5-nitropyridine Properties

Melting point 42 °C
Boiling point 246.0±35.0 °C(Predicted)
Density 1.555±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -5.60±0.18(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H319-H302+H312+H332-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
HS Code  2933399990

2,4-difluoro-5-nitropyridine price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC50088 2,4-Difluoro-5-nitropyridine 95% 60186-15-4 250mg $25 2026-06-04 Buy
Apolloscientific PC50088 2,4-Difluoro-5-nitropyridine 95% 60186-15-4 1g $69 2026-06-04 Buy
Apolloscientific PC50088 2,4-Difluoro-5-nitropyridine 95% 60186-15-4 5g $319 2026-06-04 Buy
Matrix Scientific 096416 2,4-Difluoro-5-nitropyridine 60186-15-4 250.00mg $416 2026-05-18 Buy
Matrix Scientific 096416 2,4-Difluoro-5-nitropyridine 60186-15-4 1.00g $924 2026-05-18 Buy
Product number Packaging Price Buy
PC50088 250mg $25 Buy
PC50088 1g $69 Buy
PC50088 5g $319 Buy
096416 250.00mg $416 Buy
096416 1.00g $924 Buy

2,4-difluoro-5-nitropyridine Chemical Properties,Uses,Production

Synthesis

2,4-DICHLORO-5-NITROPYRIDINE

4487-56-3

2,4-difluoro-5-nitropyridine

60186-15-4

General procedure for the synthesis of 2,4-difluoro-5-nitropyridine from 2,4-dichloro-5-nitropyridine: In a 250 mL round-bottomed flask, 2,4-dichloro-5-nitropyridine (0.73 g, 3.8 mmol), potassium fluoride (0.659 g, 11.3 mmol) and 18-crown-6 (0.160 g, 0.605 mmol) were added to an N-methyl pyrrolidone (3 mL) solution to form a brown suspension. The reaction mixture was heated to reflux at 100 °C under nitrogen atmosphere for 3 hours. Upon completion of the reaction, the mixture was partitioned between water and a mixed ether/hexane solvent. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the brown solid product 2,4-difluoro-5-nitropyridine (0.515 g, 85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) δ 9.07 (d, J = 9.7 Hz, 1H), 6.96 (dd, J = 9.5, 2.5 Hz, 1H) and 19F NMR (376 MHz, CDCl3) δ -52.20 (d, J = 29.3 Hz), -98.13 (d, J = 28.9 Hz).

References

[1] Patent: WO2015/69594, 2015, A1. Location in patent: Page/Page column 106
[2] Patent: WO2018/98413, 2018, A1. Location in patent: Page/Page column 16
[3] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 94; 95

2,4-difluoro-5-nitropyridine Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-nitropyridine N-Methyl-2-pyrrolidone Potassium fluoride 18-Crown-6

Preparation Products

2,4-difluoro-5-nitropyridine Suppliers

Global( 68)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
SynAsst Chemical. 021-60343070 China 12731 55
Cochemical Ltd. 029-86115547 17791676824 sales@cochemical.com China 3014 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Hunan HuaTeng Pharmaceutical Co., Ltd., 400-8592883 15367835770 sales@huatengsci.com China 5869 58
Shanghai AQBioPharma Co., Ltd. 13661411401 yinglv.que@aqbiopharma.com.cn China 2976 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Xi'an NewProChem Co.,Ltd. 15332490153 newprochem@126.com China 991 55
Supplier Advantage
Nanjing Chemlin Chemical Co., Ltd 64
Chiba Pharmaceutical Science and technology Co, Ltd. 55
SynAsst Chemical. 55
Cochemical Ltd. 58
Bide Pharmatech Ltd. 60
Hunan HuaTeng Pharmaceutical Co., Ltd., 58
Shanghai AQBioPharma Co., Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50
Cool Pharm, Ltd 58
Xi'an NewProChem Co.,Ltd. 55

View Lastest Price from 2,4-difluoro-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-difluoro-5-nitropyridine pictures 2020-02-19 2,4-difluoro-5-nitropyridine
60186-15-4
 $7.00 1KG 99% 100kg Career Henan Chemical Co

2,4-difluoro-5-nitropyridine Spectrum

2,4-difluoro-5-nitropyridine(60186-15-4)19FNMR

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2,4-difluoro-5-nitropyridine 4-difluoro-5-nitropyridine Pyridine, 2,4-difluoro-5-nitro- 60186-15-4