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3(R)-HYDROXYMETHYLMORPHOLINE

3(R)-HYDROXYMETHYLMORPHOLINE Structure
3(R)-HYDROXYMETHYLMORPHOLINE structure
CAS No.
211053-49-5
Chemical Name:
3(R)-HYDROXYMETHYLMORPHOLINE
Synonyms
(R)-morpholin-3-ylmethanol;(R)-3-Morpholinemethanol;(3R)-3-Morpholinemethanol;(3R)-morpholine-3-methanol;3-MorpholineMethanol, (3R)-;3(R)-HYDROXYMETHYLMORPHOLINE;(R)-3-Hydroxymethylmorpholine;((3R)-Morpholin-3-yl)methanol;(3R)-3-Morpholinemethanol,99%e.e.;3(R)-HYDROXYMETHYLMORPHOLINE HCL,
CBNumber:
CB8367459
Molecular Formula:
C5H11NO2
Molecular Weight:
117.15
MDL Number:
MFCD06799479
MOL File:
211053-49-5.mol
MSDS File:
SDS
Last updated:2026-05-28 03:39:25
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3(R)-HYDROXYMETHYLMORPHOLINE Properties

Melting point 78-81°C
Boiling point 218℃
Density 1.045
Flash point 86℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform
form Solid
pka 14.85±0.10(Predicted)
color White to Off-White
optical activity Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22

3(R)-HYDROXYMETHYLMORPHOLINE price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FH24426 (3R)-Hydroxymethylmorpholine 211053-49-5 500mg $150 2026-06-04 Buy
Biosynth FH24426 (3R)-Hydroxymethylmorpholine 211053-49-5 250mg $150 2026-06-04 Buy
Biosynth FH24426 (3R)-Hydroxymethylmorpholine 211053-49-5 100mg $150 2026-06-04 Buy
Biosynth FH24426 (3R)-Hydroxymethylmorpholine 211053-49-5 1000mg $210 2026-06-04 Buy
Matrix Scientific 303230 (R)-3-Hydroxymethylmorpholine 211053-49-5 1.00g $62 2026-05-19 Buy
Product number Packaging Price Buy
FH24426 500mg $150 Buy
FH24426 250mg $150 Buy
FH24426 100mg $150 Buy
FH24426 1000mg $210 Buy
303230 1.00g $62 Buy

3(R)-HYDROXYMETHYLMORPHOLINE Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

A chiral morpholine drivative.

Synthesis

(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE

101376-26-5

3(R)-HYDROXYMETHYLMORPHOLINE

211053-49-5

General procedure for the synthesis of (R)-3-hydroxymethylmorpholine from (R)-(4-benzyl-3-morpholinyl)-methanol: (a) Preparation of (3R)-morpholin-3-ylmethanol: [(3R)-4-benzylmorpholin-3-yl]methanol (cf. J. Med. Chem.; 29; 1986; 1288-1290; 1.1 g, 5.4 mmol) was dissolved in ethanol (25 mL), palladium hydroxide (20% loaded on activated carbon, 0.7 g) and acetic acid (0.5 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.2 bar). After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation under reduced pressure. The residue except 200 mg was dissolved in ether (1 mL) and tetrahydrofuran (10 mL). The solution was purified by passing it through a strong cation exchange column (Isolute SCX-2, 10 g). The column was first washed with tetrahydrofuran, followed by elution of the target product with ammonia-saturated methanol. The solvent was removed by evaporation under reduced pressure to give 0.3625 g (57% yield) of (3R)-morpholin-3-ylmethanol as an oil.1H NMR (500 MHz, CD3OD): δ 2.9 (m, 3H), 3.3 (t, 1H), 3.5 (m, 3H), 3.7-3.9 (m, 2H).

References

[1] Patent: WO2006/137790, 2006, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244

3(R)-HYDROXYMETHYLMORPHOLINE synthesis

106973-37-9
211053-49-5
Synthesis of 3(R)-HYDROXYMETHYLMORPHOLINE from (3S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid

3(R)-HYDROXYMETHYLMORPHOLINE Preparation Products And Raw materials

Raw materials

(3S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid (R)-4-Benzyl-3-hydroxymethylmorpholine Ammonia Hydrogen Ethanol
Acetic acid Methanol

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Preparation Products

3(R)-HYDROXYMETHYLMORPHOLINE Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Aemon Chemical 0086-755-86198205 acinfo@aemonchem.com China 1928 57
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
ForeChem (Nantong) Technology Co.,Ltd. 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Chemsky（shanghai）International Co.,Ltd. 50
Shandong Xiya Chemical Co., Ltd 57
Shanghai Ennopharm Co., Ltd. 65
Aemon Chemical 57
Hangzhou Sage Chemical Co., Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55

View Lastest Price from 3(R)-HYDROXYMETHYLMORPHOLINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3(R)-HYDROXYMETHYLMORPHOLINE pictures 2019-07-06 3(R)-HYDROXYMETHYLMORPHOLINE
211053-49-5
 $7.00 1kg 99% 100kg Career Henan Chemical Co

3(R)-HYDROXYMETHYLMORPHOLINE Spectrum

3(R)-HYDROXYMETHYLMORPHOLINE(211053-49-5)1HNMR

211053-49-5(3(R)-HYDROXYMETHYLMORPHOLINE)Related Search:

(S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE,(S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (R )-2-Hydroxymethylmorpholine,(R)-2-Hydroxymethylmorpholine HCl AC480 (BMS-599626) (S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid (S)-3-MORPHOLINECARBOXYLIC ACID HCL
(R)-4-Boc-3-hydroxymethylmorpholine 2-HYDROXYMETHYLMORPHOLINE,2-HYDROXYMETHYLMORPHOLINE 95% (R)-N-Boc-2-Hydroxymethylmorpholine Morpholine-3,4-dicarboxylic acid 4-tert-butyl ester 2-Hydroxymethyl-4-Boc-morpholine
3(S)-Hydroxymethyl-4-bocmorpholine 3-Morpholinecarboxylicacid,methylester,(3S)-(9CI) (S)-FMOC-2-CARBOXYMORPHOLINE (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride (S)-ETHYL 4-BENZYL-5-OXO-MORPHOLINE-3-CARBOXYLATE
(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE (+)-PD 128907 (S)-N-BENZYL-2-HYDROXYMETHYLMORPHOLINE

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3(R)-HYDROXYMETHYLMORPHOLINE 3(R)-HYDROXYMETHYLMORPHOLINE HCL, ((3R)-Morpholin-3-yl)methanol (3R)-3-Morpholinemethanol (R)-3-Hydroxymethylmorpholine 3(R)-Hydroxymethylmorpholine hydrochloride (3R)-Morpholin-3-ylMethanol hydrochloride 3-MorpholineMethanol, (3R)- (3R)-morpholine-3-methanol (3R)-3-Morpholinemethanol,99%e.e. (R)-3-Morpholinemethanol (R)-morpholin-3-ylmethanol 211053-49-5 Chiral Reagents Heterocycles pharmacetical