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3(R)-HYDROXYMETHYLMORPHOLINE

3(R)-HYDROXYMETHYLMORPHOLINE Structure
3(R)-HYDROXYMETHYLMORPHOLINE structure
CAS No.
211053-49-5
Chemical Name:
3(R)-HYDROXYMETHYLMORPHOLINE
Synonyms
(R)-3-Morpholinemethanol;(3R)-3-Morpholinemethanol;(R)-morpholin-3-ylmethanol;(3R)-morpholine-3-methanol;3-MorpholineMethanol, (3R)-;3(R)-HYDROXYMETHYLMORPHOLINE;((3R)-Morpholin-3-yl)methanol;(R)-3-Hydroxymethylmorpholine;(3R)-3-Morpholinemethanol,99%e.e.;3(R)-HYDROXYMETHYLMORPHOLINE HCL,
CBNumber:
CB8367459
Molecular Formula:
C5H11NO2
Molecular Weight:
117.15
MDL Number:
MFCD06799479
MOL File:
211053-49-5.mol
MSDS File:
SDS
Last updated:2026-05-20 15:44:28
Product description Number Pack Size Price
(R)-3-Hydroxymethylmorpholine 303230 1.00g $62
(R)-3-Hydroxymethylmorpholine 303230 5.00g $232
(R)-3-Hydroxymethylmorpholine 303230 25.00g $822
(R)-3-Hydroxymethylmorpholine 95+% H40409 100mg $25
(R)-3-Hydroxymethylmorpholine 95+% H40409 250mg $30
More product size
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3(R)-HYDROXYMETHYLMORPHOLINE Properties

Melting point 78-81°C
Boiling point 218℃
Density 1.045
Flash point 86℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Chloroform
pka 14.85±0.10(Predicted)
form Solid
color White to Off-White
optical activity Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22

3(R)-HYDROXYMETHYLMORPHOLINE price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 303230 (R)-3-Hydroxymethylmorpholine 211053-49-5 1.00g $62 2026-05-19 Buy
Matrix Scientific 303230 (R)-3-Hydroxymethylmorpholine 211053-49-5 5.00g $232 2026-05-19 Buy
Matrix Scientific 303230 (R)-3-Hydroxymethylmorpholine 211053-49-5 25.00g $822 2026-05-19 Buy
Synthonix H40409 (R)-3-Hydroxymethylmorpholine 95+% 211053-49-5 100mg $25 2026-05-06 Buy
Synthonix H40409 (R)-3-Hydroxymethylmorpholine 95+% 211053-49-5 250mg $30 2026-05-06 Buy
Product number Packaging Price Buy
303230 1.00g $62 Buy
303230 5.00g $232 Buy
303230 25.00g $822 Buy
H40409 100mg $25 Buy
H40409 250mg $30 Buy

3(R)-HYDROXYMETHYLMORPHOLINE Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

A chiral morpholine drivative.

Synthesis

(R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE

101376-26-5

3(R)-HYDROXYMETHYLMORPHOLINE

211053-49-5

General procedure for the synthesis of (R)-3-hydroxymethylmorpholine from (R)-(4-benzyl-3-morpholinyl)-methanol: (a) Preparation of (3R)-morpholin-3-ylmethanol: [(3R)-4-benzylmorpholin-3-yl]methanol (cf. J. Med. Chem.; 29; 1986; 1288-1290; 1.1 g, 5.4 mmol) was dissolved in ethanol (25 mL), palladium hydroxide (20% loaded on activated carbon, 0.7 g) and acetic acid (0.5 mL). The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere (1.2 bar). After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by evaporation under reduced pressure. The residue except 200 mg was dissolved in ether (1 mL) and tetrahydrofuran (10 mL). The solution was purified by passing it through a strong cation exchange column (Isolute SCX-2, 10 g). The column was first washed with tetrahydrofuran, followed by elution of the target product with ammonia-saturated methanol. The solvent was removed by evaporation under reduced pressure to give 0.3625 g (57% yield) of (3R)-morpholin-3-ylmethanol as an oil.1H NMR (500 MHz, CD3OD): δ 2.9 (m, 3H), 3.3 (t, 1H), 3.5 (m, 3H), 3.7-3.9 (m, 2H).

References

[1] Patent: WO2006/137790, 2006, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244

3(R)-HYDROXYMETHYLMORPHOLINE synthesis

106973-37-9
211053-49-5
Synthesis of 3(R)-HYDROXYMETHYLMORPHOLINE from (3S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid

3(R)-HYDROXYMETHYLMORPHOLINE Preparation Products And Raw materials

Raw materials

(3S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE Ammonia Hydrogen Ethanol
Acetic acid Methanol

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Preparation Products

3(R)-HYDROXYMETHYLMORPHOLINE Suppliers

Global( 113)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29816 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9653 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Baoji Guokang Healthchem co.,ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
changzhou huayang technology co., ltd 		58

View Lastest Price from 3(R)-HYDROXYMETHYLMORPHOLINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3(R)-HYDROXYMETHYLMORPHOLINE pictures 2019-07-06 3(R)-HYDROXYMETHYLMORPHOLINE
211053-49-5
 US $7.00 / kg 1kg 99% 100kg Career Henan Chemical Co

3(R)-HYDROXYMETHYLMORPHOLINE Spectrum

3(R)-HYDROXYMETHYLMORPHOLINE(211053-49-5)1HNMR

211053-49-5(3(R)-HYDROXYMETHYLMORPHOLINE)Related Search:

4-N-BOC-2-HYDROXYMETHYLMORPHOLINE MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER (R)-4-Boc-3-hydroxymethylmorpholine (S)-3-MORPHOLINECARBOXYLIC ACID HCL AC480 (BMS-599626)
(S)-4-Benzyl-5-oxomorpholine-3-carboxylic acid (R )-2-Hydroxymethylmorpholine,(R)-2-Hydroxymethylmorpholine HCl (S)-3-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE,(S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester 2-HYDROXYMETHYLMORPHOLINE,2-HYDROXYMETHYLMORPHOLINE 95%
(R)-N-Boc-2-Hydroxymethylmorpholine 4-CBZ-3(S)-MORPHOLINECARBOXYLIC ACID (S)-ETHYL 4-BENZYL-5-OXO-MORPHOLINE-3-CARBOXYLATE 3(R)-HYDROXYMETHYLMORPHOLINE (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE
(+)-PD 128907 3-Morpholinecarboxylicacid,methylester,(3S)-(9CI) (S)-FMOC-2-CARBOXYMORPHOLINE

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3(R)-HYDROXYMETHYLMORPHOLINE 3(R)-HYDROXYMETHYLMORPHOLINE HCL, (R)-morpholin-3-ylmethanol ((3R)-Morpholin-3-yl)methanol (3R)-3-Morpholinemethanol (R)-3-Hydroxymethylmorpholine 3(R)-Hydroxymethylmorpholine hydrochloride (3R)-Morpholin-3-ylMethanol hydrochloride 3-MorpholineMethanol, (3R)- (3R)-morpholine-3-methanol (3R)-3-Morpholinemethanol,99%e.e. (R)-3-Morpholinemethanol 211053-49-5 Chiral Reagents Heterocycles pharmacetical