Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>DUP-697

DUP-697

DUP-697 Structure
DUP-697 structure
CAS No.
88149-94-4
Chemical Name:
DUP-697
Synonyms
BFMeT;DUP-697;DuP697,DuP 697;DuP-697 Assay Reagent;DuP-697, 10 mM in DMSO;5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE;Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-
CBNumber:
CB8397180
Molecular Formula:
C17H12BrFO2S2
Molecular Weight:
411.31
MDL Number:
MFCD02684527
MOL File:
88149-94-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:50
Request For Quotation

DUP-697 Properties

storage temp. 2-8°C
solubility DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form White to off-white solid.
color White to off-white
FDA UNII MRWLZPOFPA

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36

DUP-697 price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70645 DuP-697 ≥98% 88149-94-4 5mg $121 2026-04-30 Buy
Cayman Chemical 70645 DuP-697 ≥98% 88149-94-4 10mg $193 2026-04-30 Buy
Cayman Chemical 70645 DuP-697 ≥98% 88149-94-4 25mg $448 2026-04-30 Buy
Cayman Chemical 70645 DuP-697 ≥98% 88149-94-4 50mg $833 2026-04-30 Buy
Usbiological 255204 DuP 697 Asreported 88149-94-4 10mg $423 2026-06-03 Buy
Product number Packaging Price Buy
70645 5mg $121 Buy
70645 10mg $193 Buy
70645 25mg $448 Buy
70645 50mg $833 Buy
255204 10mg $423 Buy

DUP-697 Chemical Properties,Uses,Production

Description

DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.

Uses

DuP-697 is a thiophene that inhibits COX-2 and acts as a NSAID.

Definition

ChEBI: DuP 697 is a member of thiophenes.

Biological Activity

Potent and selective inhibitor of cyclooxygenase-2 (IC 50 values are 10 and 800 nM for COX-2 and COX-1 respectively). Inhibits prostaglandin synthesis and is anti-inflammatory in vivo . Orally active.

storage

Store at +4°C

References

[1] STACIA KARGMAN. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells[J]. Biochemical pharmacology, 1996, 52 7: Pages 1113-1125. DOI: 10.1016/0006-2952(96)00462-5
[2] K SEIBERT. Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.[J]. British Journal of Pharmacology, 1996, 117 6: 1016-1020. DOI: 10.1111/j.1476-5381.1996.tb16691.x
[3] MOTI ROSENSTOCK  Gilad R  Abraham Danon. PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1999, 1440 1: Pages 127-137. DOI: 10.1016/s1388-1981(99)00105-5

DUP-697 Preparation Products And Raw materials

Raw materials

Preparation Products

DUP-697 Suppliers

Global( 87)Suppliers
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Shanghai Hekang Biotechnology Co., Ltd. 17721021104 18939837085 2880152141@qq.com China 1840 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Henan CoreyChem Co., Ltd 0371-86658258 info@coreychem.com China 10442 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Nanjing Dulai Biotechnology Co., Ltd. 55
Shanghai Hekang Biotechnology Co., Ltd. 55
EMMX Biotechnology LLC 60
Henan CoreyChem Co., Ltd 58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
BOC Sciences 58
TargetMol Chemicals Inc. 58

DUP-697 Spectrum

DUP-697(88149-94-4)1HNMR

88149-94-4(DUP-697)Related Search:

Ibuprofen Phenidone (R)-(-)-IBUPROFEN Meloxicam NS-398
Indometacin Piroxicam (S)-(+)-Ibuprofen 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide Naproxen
MECLOFENAMATE SODIUM SC-560 Sulindac sulfide APHS N-(2-Phenylethyl)-indomethacin amide
2-Bromo-5-phenylthiophene 2-(4-Fluorophenyl)-thiophene DUP-697

1of4

DUP-697 5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE BFMeT DuP-697 Assay Reagent Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]- DuP697,DuP 697 DuP-697, 10 mM in DMSO 88149-94-4 C17H12BrFO2S2 Lipid signaling API intermediates