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2-Bromo-1-ethylpyridinium tetrafluoroborate

2-Bromo-1-ethylpyridinium tetrafluoroborate Structure
2-Bromo-1-ethylpyridinium tetrafluoroborate structure
CAS No.
878-23-9
Chemical Name:
2-Bromo-1-ethylpyridinium tetrafluoroborate
Synonyms
2-bromo-1-ethylpyridin-1-ium tetrafluoroborate;BEPyBr;BEP TETRAFLUOROBORATE;bromoethylpyridiniumtetrafluoroborate;2-Brom-1-ethylpyridiniumtetrafluoroborat;2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBOR;2-Bromo-1-ethylpyridinium tetrafluoroborat;1-Ethyl-2-bromopyridinium·tetrafluoroborate;2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBORATE;2-Bromo-1-ethylpyridinium Tetra uoroborate
CBNumber:
CB8399472
Molecular Formula:
C7H9BBrF4N
Molecular Weight:
273.86
MDL Number:
MFCD00060046
MOL File:
878-23-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:54:42
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2-Bromo-1-ethylpyridinium tetrafluoroborate Properties

Melting point 103-107 °C
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Crystalline Powder
color White
Water Solubility very faint turbidity
BRN 4059265
Major Application peptide synthesis
InChI InChI=1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8;2-1(3,4)5/h3-6H,2H2,1H3;/q+1;-1
InChIKey YJDXVQLBIAJTHP-UHFFFAOYSA-N
SMILES [N+]1(CC)C=CC=CC=1Br.[B-](F)(F)(F)F
CAS DataBase Reference 878-23-9(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P260-P264-P270-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36/37/39-26
RIDADR  1759
WGK Germany  3
F  9-21
Hazard Note  Irritant
HazardClass  8
PackingGroup  III
HS Code  29333990
Storage Class 11 - Combustible Solids

2-Bromo-1-ethylpyridinium tetrafluoroborate price More Price(64)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S765686 2-BROMO-1-ETHYLPYRIDINIUMTETRAFLUOROBORATE AldrichCPR 878-23-9 1 unit $32.7 2026-04-30 Buy
Sigma-Aldrich 77386 2-Bromo-1-ethyl-pyridinium tetrafluoroborate ≥97.0% (T) 878-23-9 5G $206 2026-04-30 Buy
Sigma-Aldrich S765686 2-Bromo-1-ethylpyridinium Tetrafluoroborate Aldrich 878-23-9 50mg $29.8 2024-03-01 Buy
TCI Chemical B1036 2-Bromo-1-ethylpyridinium Tetrafluoroborate >98.0%(HPLC)(T) 878-23-9 5g $93 2026-04-30 Buy
TCI Chemical B1036 2-Bromo-1-ethylpyridinium Tetrafluoroborate >98.0%(HPLC)(T) 878-23-9 25g $234 2026-04-30 Buy
Product number Packaging Price Buy
S765686 1 unit $32.7 Buy
77386 5G $206 Buy
S765686 50mg $29.8 Buy
B1036 5g $93 Buy
B1036 25g $234 Buy

2-Bromo-1-ethylpyridinium tetrafluoroborate Chemical Properties, Uses, Production

Uses

2-Bromo-1-ethylpyridinium Tetrafluoroborate is a carboxyl activation and coupling reagent for peptide synthesis.

Uses

2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:

  • The synthesis of N-methylated peptides in solution and solid phase.
  • The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.

General Description

2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2bromo pyridine.

reaction suitability

reaction type: Coupling Reactions

Synthesis

Procedure: trifluoroacetic acid (9.2 ml, 12.0 mg molecule) was added to a solution (3.00 g, 12.0 mg molecule) of N-Boc-N-methyl-L-leucine methyl ester (50 ml) at -20C. This mixture was heated to room temperature and stirred for 2 h. The aqueous layer was extracted with CH2Cl2 (2x) over Na2SO4 in order to structure and neutralize the carefully sat. aq. NaHCO3. the aqueous layer was extracted with CH2Cl2 (2x) and said composite organic layer was dried over Na2SO4. After solvent removal in evacuation, the free amine was dissolved in dry CH2Cl2 (50 mL) and N-Cbz-(L)-valine (3.32 g, 13.2 mmol) and DIEA (4.1 mL, 24.0 mmol) were added. Then, a small amount of BEP (3.61 g, 13.2 mmol) was added at room temperature to obtain a yellow solution. It was stirred overnight, diluted with CH2Cl2, and then washed with 1 mol /L aq. KHSO4, sataq . NaHCO3 and brine to wash. The solvent (Na2SO4) was removed after drying and the residue was purified by column chromatography (silica gel, PE:EtOAc 8:2). Dipeptide 1 (4.08 g, 10.4 mmol, 87%) was a colorless resin.

2-Bromo-1-ethylpyridinium tetrafluoroborate synthesis

109-04-6
368-39-8
878-23-9
Synthesis of 2-Bromo-1-ethylpyridinium tetrafluoroborate from 2-Bromopyridine and Triethyloxonium tetrafluoroborate

2-Bromo-1-ethylpyridinium tetrafluoroborate Preparation Products And Raw materials

Raw materials

Triethyloxonium tetrafluoroborate 2-Bromopyridine

Preparation Products

2-Bromo-1-ethylpyridinium tetrafluoroborate Suppliers

Global Suppliers ( 169)
Supplier Tel Email Country ProdList Advantage
Shanghai Medpep Co., Ltd 021-65566949 13901795941 market@medpep.com China 156 66
Zhengzhou Ruike Biochemical Technology Co., Ltd. 18521304688;17324816296 421551521@qq.com China 280 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Supplier Advantage
Shanghai Medpep Co., Ltd 66
Zhengzhou Ruike Biochemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Sichuan Kulinan Technology Co., Ltd 57

View Latest Price from 2-Bromo-1-ethylpyridinium tetrafluoroborate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-1-ethylpyridinium tetrafluoroborate pictures 2026-08-20 2-Bromo-1-ethylpyridinium tetrafluoroborate
878-23-9
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Bromo-1-ethylpyridinium tetrafluoroborate pictures 2025-04-04 2-Bromo-1-ethylpyridinium tetrafluoroborate
878-23-9
 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
2-Bromo-1-ethylpyridinium tetrafluoroborate pictures 2020-01-10 2-Bromo-1-ethylpyridinium tetrafluoroborate
878-23-9
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

2-Bromo-1-ethylpyridinium tetrafluoroborate Spectrum

2-Bromo-1-ethylpyridinium tetrafluoroborate(878-23-9)MS2-Bromo-1-ethylpyridinium tetrafluoroborate(878-23-9)1HNMR2-Bromo-1-ethylpyridinium tetrafluoroborate(878-23-9)IR12-Bromo-1-ethylpyridinium tetrafluoroborate(878-23-9)IR2

878-23-9 (2-Bromo-1-ethylpyridinium tetrafluoroborate) Related Search:

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2-Bromopyridine 2-Bromo-1-ethylpyridinium tetrafluoroborate

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bromoethylpyridiniumtetrafluoroborate BEP TETRAFLUOROBORATE 2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBORATE 2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBORATE (BEP) 2-Bromo-1-ethylpyridinium tetrafluoroborate 98% 2-Bromo-1-ethylpyridiniumtetrafluoroborate98% 2-BROMO-1-ETHYLPYRIDINIUM TETRAFLUOROBOR 1-Ethyl-2-bromopyridinium·tetrafluoroborate 1-Ethyl-2-bromopyridinium·tetrafluoroboronanion 2-Bromo-N-ethylpyridinium tetrafluoroborate 98% 2-Brom-1-ethylpyridiniumtetrafluoroborat 2-Bromo-1-ethylpyridinium Tetrafluoroborate > 2-Bromo-1-ethylpyridinium tetrafluoroborate ISO 9001：2015 REACH 2-Bromo-1-ethyl-pyridinium tetrafluoroborate, 97%, 2-Bromo-1-ethylpyridinium Tetra uoroborate 2-Bromo-N-ethylpyridinium tetrafluoroborate 2-Bromo-1-ethylpyridinium tetrafluoroborat 2-bromo-1-ethylpyridin-1-ium tetrafluoroborate BEPyBr 878-23-9 C7H9BrNBF4 C7H9BBrF4N Active Esters/Additives Tetrafluoroborates Pyridinium Compounds B (Classes of Boron Compounds) Condensation & Active Esterification Synthetic Reagents Coupling B (Classes of Boron Compounds) Condensation & Active Esterification Pyridinium Compounds Synthetic Organic Chemistry Tetrafluoroborates