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N-(tert-Butoxycarbonyl)-L-glutamine

N-(tert-Butoxycarbonyl)-L-glutamine structure

CAS No.: 13726-85-7

Chemical Name:: N-(tert-Butoxycarbonyl)-L-glutamine

Synonyms: BOC-GLN;BOC-L-GLUTAMINE;BOC-L-GLN;BOC-L-GLN-OH;n-OH;NSC 334370;BOC-GLUTAMINE;Boc-Gln-OH 98%;TBOC-L-GLUTAMINE;N-t-BOC-L-Gln-OH

CBNumber:: CB8436290

Molecular Formula:: C10H18N2O5

Molecular Weight:: 246.26

MDL Number:: MFCD00065571

MOL File:: 13726-85-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-15 22:31:22

Product description	Number	Pack Size	Price
Boc-Gln-OH 98%	408441	25g	$155
Nalpha-(tert-Butoxycarbonyl)-L-glutamine >98.0%(HPLC)(T)	B1649	10g	$67
Nalpha-(tert-Butoxycarbonyl)-L-glutamine >98.0%(HPLC)(T)	B1649	25g	$132
tert-Butoxycarbonyl-L-glutamine ≥98%(Titration)	263391	250g	$496
tert-Butoxycarbonyl-L-glutamine ≥98%(Titration)	263391	500g	$744
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N-(tert-Butoxycarbonyl)-L-glutamine Properties

Melting point	113-116 °C (dec.)(lit.)
alpha	-3.5 º (c=2,C2H5OH)
Boiling point	389.26°C (rough estimate)
Density	1.2430 (rough estimate)
refractive index	-4 ° (C=2, EtOH)
storage temp.	Sealed in dry,2-8°C
solubility	Soluble in DMSO and methanol. Soluble in 1 mmole in 2 ml DMF.
form	Solid
pka	3.84±0.10(Predicted)
color	White
optical activity	[α]20/D 3.5°, c = 1 in ethanol
BRN	2127805
Major Application	peptide synthesis
InChI	InChI=1S/C10H18N2O5/c1-10(2,3)17-9(16)12-6(8(14)15)4-5-7(11)13/h6H,4-5H2,1-3H3,(H2,11,13)(H,12,16)(H,14,15)/t6-/m0/s1
InChIKey	VVNYDCGZZSTUBC-LURJTMIESA-N
SMILES	C(O)(=O)[C@H](CCC(N)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference	13726-85-7(CAS DataBase Reference)
EPA Substance Registry System	L-Glutamine, N2-[(1,1-dimethylethoxy)carbonyl]- (13726-85-7)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H302+H312+H332-H315

Precautionary statements

P280-P301+P312-P362+P364

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

TSCA

TSCA listed

HS Code

29241990

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	0
1		0

N-(tert-Butoxycarbonyl)-L-glutamine price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	408441	Boc-Gln-OH 98%	13726-85-7	25g	$155	2026-04-30	Buy
TCI Chemical	B1649	Nalpha-(tert-Butoxycarbonyl)-L-glutamine >98.0%(HPLC)(T)	13726-85-7	10g	$67	2026-04-30	Buy
TCI Chemical	B1649	Nalpha-(tert-Butoxycarbonyl)-L-glutamine >98.0%(HPLC)(T)	13726-85-7	25g	$132	2026-04-30	Buy
Usbiological	263391	tert-Butoxycarbonyl-L-glutamine ≥98%(Titration)	13726-85-7	250g	$496	2026-06-03	Buy
Usbiological	263391	tert-Butoxycarbonyl-L-glutamine ≥98%(Titration)	13726-85-7	500g	$744	2026-06-03	Buy

Product number	Packaging	Price	Buy
408441	25g	$155	Buy
B1649	10g	$67	Buy
B1649	25g	$132	Buy
263391	250g	$496	Buy
263391	500g	$744	Buy

N-(tert-Butoxycarbonyl)-L-glutamine Chemical Properties,Uses,Production

Chemical Properties

White fine crystalline powder

Uses

Protected Glutamine.

Uses

It is employed in the synthesis and analgesic activity of human .beta.-endorphin.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

56-85-9

24424-99-5

13726-85-7

Example 1: Synthesis of N-(Boc)-L-glutamine (1): L-glutamine (25 g, 0.17 mol) was dissolved in 300 mL of aqueous NaOH solution (21.9 g, 0.547 mol). The resulting solution was cooled to below 10 °C, followed by the slow addition of a THF (150 mL) solution of Boc anhydride (0.205 mol) (note that the reaction is exothermic). The reaction mixture was stirred continuously at 25 °C for 20 hours. The progress of the reaction was monitored by TLC and the unfolding agent was MeOH:CH2Cl2 (1:1, containing 0.1% AcOH). Upon completion of the reaction, the organic phase was separated and the aqueous phase was extracted with hexane (100 mL) and acidified to pH 2 with 2N HCl, followed by extraction with ethyl acetate (2 x 250 mL). The organic phases were combined, dried with Na2SO4 and the solvent was evaporated in vacuum. The resulting viscous oily product was diluted with dichloromethane and evaporated again. After standing for 2-3 days, it was crystallized from hexane to give N-(Boc)-L-glutamine (1) (37.5 g, 89% yield) as a colorless solid. The product was characterized by 1H NMR (DMSO, 300 MHz) and ESI-MS (m/z: 269 [M+Na]+).

References

[1] Journal of the American Chemical Society, 1997, vol. 119, # 17, p. 4086 - 4087
[2] Patent: WO2015/189856, 2015, A1. Location in patent: Page/Page column 14
[3] Synthetic Communications, 2008, vol. 38, # 2, p. 162 - 169
[4] Bulletin of the Korean Chemical Society, 2012, vol. 33, # 8, p. 2777 - 2780
[5] Organic Syntheses, 1985, vol. 63, p. 160 - 160

N-(tert-Butoxycarbonyl)-L-glutamine Preparation Products And Raw materials

Raw materials

L-Glutamine Di-tert-butyl dicarbonate Tetrahydrofuran Sodium hydroxide Water

Preparation Products

3-AMINO-PIPERIDINE-2,6-DIONE N-Boc-N'-(9-xanthenyl)-L-glutamine Butanoic acid, 4-cyano-2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)- (S)-Tert-Butyl (1,5-diaMino-1,5-dioxopentan-2-yl)carbaMate

N-(tert-Butoxycarbonyl)-L-glutamine Suppliers

Global( 477)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	sales01@jndxj.com	China	288	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+86-15680023009	ni@enlaibio.com	China	1103	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6361	58

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from N-(tert-Butoxycarbonyl)-L-glutamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-07	Boc-L-Gln-OH 13726-85-7		1KG	98%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-07	Boc-L-Gln-OH 13726-85-7		1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-07-30	N-(tert-Butoxycarbonyl)-L-glutamine 13726-85-7	$100.00-2000.00	1kg	98%	20tons	Anhui Dexinjia Biopharm Co., Ltd

Boc-L-Gln-OH
13726-85-7
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-L-Gln-OH
13726-85-7
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

N-(tert-Butoxycarbonyl)-L-glutamine
13726-85-7
$100.00-2000.00
98%
Anhui Dexinjia Biopharm Co., Ltd

N-(tert-Butoxycarbonyl)-L-glutamine Spectrum

N-(tert-Butoxycarbonyl)-L-glutamine(13726-85-7)MS N-(tert-Butoxycarbonyl)-L-glutamine(13726-85-7)¹HNMR N-(tert-Butoxycarbonyl)-L-glutamine(13726-85-7)¹³CNMR N-(tert-Butoxycarbonyl)-L-glutamine(13726-85-7)IR1 N-(tert-Butoxycarbonyl)-L-glutamine(13726-85-7)IR2

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1of4

n2-[(1,1-dimethylethoxy)carbonyl]-l-glutamin BOC-GLUTAMINE (S)-5-AMINO-2-(TERT-BUTOXYCARBONYLAMINO)-5-OXOPENTANOIC ACID N(ɑ)-Boc-L-glutamine, 98+% BOC-L-GLUTAMINE extrapure Boc-L-glutamine, Nα-(tert-Butoxycarbonyl)-L-glutamine L-Glutamine, N(2)-[(1,1-dimethylethoxy)carbonyl]- N-(tert-Butoxycarbonyl)-3-(carbamoylmethyl)alanine N2-[(1,1-Dimethylethoxy)carbonyl]-L-glutamine Nα-(tert-Butyloxycarbonyl)-L-glutamine N(^a)-Boc-L-glutamine, 98+% tert-Butoxycarbonyl-L-glutamine Nα- (tert-Butoxycarbonyl)-L-glutamine ,99% Boc-Gln-OH,Nα-(tert-Butoxycarbonyl)-L-glutamine, Boc-L-glutamine L-GLUTAMINE-N-T-BOC BOC-L-GlutaMine(Boc-L-Gln-OH) Boc-Gln-OH (Boc-L-GlutaMine Na-(tert-Butoxycarbonyl)-L-glutaMine) N(alpha)-Boc-L-glutamine, 98+% (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-carbamoylbutanoic acid N-[amino(methoxy)methylidene]carbamic acid tert-butyl ester n-OH TBOC-L-GLUTAMINE T-BUTYLOXYCARBONYL-L-GLUTAMINE N(ALPHA)-BOC-L-GLUTAMINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMINE NALPHA-(TERT-BUTOXYCARBONYL)-L-GLUTAMINE N-ALPHA-T-BOC-L-GLUTAMINE N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMINE N-(TERT-BUTOXYCARBONYL)-L-GLUTAMINE N-T-BOC-L-GLUTAMINE N-T-BUTOXYCARBONYL-L-GLUTAMINE N_α-(tert-Butoxycarbonyl)-L-glutamine -alpha-t-BOC-L-glutamine N-α-Boc-L-glutamine N(a)-Boc-L-glutamine NA-T-BOC-L-GLUTAMINE N-TERT-BUTOXYCARBONYLGLUTAMINE Nalpha-BOC-L-Glutamine, 99+% n(à)-boc-l-glutamine n(à)-tert-butoxycarbonyl-l-glutamine N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMINE N2-[(tert-butoxy)carbonyl]-L-glutamine Boc-Gln-OH 98% L-GLUTAMINE-N-T-BOC (ALPHA-15N+) Boc-L-glutamine≥ 98% (HPLC) (S)-2-[(tert-Butoxycarbonyl)aMino]-4-carbaMoylbutanoic Acid N2-Carboxy-glutaMine N-tert-Butyl Ester NSC 334370 Nalpha-Boc-L-glutamine Boc-Gln-OH (Tert-Butoxy)Carbonyl Gln-OH n-(tert-butoxycarbonyl)-l-glutamine CAS NO.13726-85-7 Nα-(tert-Butoxycarbonyl)-L-glutamine > N-(tert-Butoxycarbonyl)-L-glutamine USP/EP/BP BOC-glutamine USP/EP/BP N-t-BOC-L-Gln-OH (2S)-5-amino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid Pomalidomide Impurity 9Q: What is Pomalidomide Impurity 9 Q: What is the CAS Number of Pomalidomide Impurity 9 Q: What is the storage condition of Pomalidomide Impurity 9 Q: What are the applications of Pomalidomide Impurity 9