4-FLUORO-3-METHOXYPHENYLBORONIC ACID
- CAS No.
- 854778-31-7
- Chemical Name:
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
- Synonyms
- uoro-3-methoxyphenyL;Elagolix Impurity 50;5-Borono-2-fluoroanisole;4-Fluoro-3-Methoxyphenylboronic;4-Fluoro-5-methoxyphenylboronic acid;4-FLUORO-3-METHOXYPHENYLBORONIC ACID;4-FLUORO-3-METHOXYBENZENEBORONIC ACID;4-Fluoro-3-methoxybenzeneboronicacid98%;4-Fluoro-3-methoxybenzeneboronic acid 98%;Boronic acid, B-(4-fluoro-3-methoxyphenyl)-
- CBNumber:
- CB9237771
- Molecular Formula:
- C7H8BFO3
- Molecular Weight:
- 169.95
- MDL Number:
- MFCD08056358
- MOL File:
- 854778-31-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | F0919 | 1g | $43 |
| 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | F0919 | 5g | $141 |
| 4-Fluoro-3-methoxyphenylboronic acid 97-105%(Assaybytitration) | 40192 | 1G | $62.59 |
| 4-Fluoro-3-methoxyphenylboronic acid 97-105%(Assaybytitration) | 40192 | 5G | $229.34 |
| 4-Fluoro-3-methoxyphenylboronic acid | 035600 | 10.00g | $38 |
| More product size | |||
| Melting point | 189-191 |
|---|---|
| Boiling point | 318.1±52.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 8.19±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C7H8BFO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,10-11H,1H3 |
| InChIKey | LUJMSRVFSBMEOY-UHFFFAOYSA-N |
| SMILES | B(C1=CC=C(F)C(OC)=C1)(O)O |
| FDA UNII | FW899DDX6U |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2931900090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
4-FLUORO-3-METHOXYPHENYLBORONIC ACID price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0919 | 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 854778-31-7 | 1g | $43 | 2026-04-30 | Buy |
| TCI Chemical | F0919 | 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) | 854778-31-7 | 5g | $141 | 2026-04-30 | Buy |
| Chem-Impex | 40192 | 4-Fluoro-3-methoxyphenylboronic acid 97-105%(Assaybytitration) | 854778-31-7 | 1G | $62.59 | 2026-05-19 | Buy |
| Chem-Impex | 40192 | 4-Fluoro-3-methoxyphenylboronic acid 97-105%(Assaybytitration) | 854778-31-7 | 5G | $229.34 | 2026-05-19 | Buy |
| Matrix Scientific | 035600 | 4-Fluoro-3-methoxyphenylboronic acid | 854778-31-7 | 10.00g | $38 | 2026-05-18 | Buy |
4-FLUORO-3-METHOXYPHENYLBORONIC ACID Chemical Properties,Uses,Production
Uses
suzuki reaction
Synthesis
103291-07-2
854778-31-7
General procedure for the synthesis of 4-fluoro-3-methoxyphenylboronic acid from 2-fluoro-5-bromoanisole: To a solution of 2-fluoro-5-bromoanisole (2.7 g, 13.1 mmol) in tetrahydrofuran (THF, 25 mL) was slowly added n-butyllithium (n-BuLi, 1.6 M solution in hexane, 11.0 mL, 17.7 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of trimethyl borate (2.7 mL, 24.3 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued at this temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (40 mL) and subsequently extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After removal of solvent by evaporation under reduced pressure, the crude product obtained was purified by grinding with a solvent mixture of ethyl acetate/hexane (1:4, v/v). After filtration, the target product 4-fluoro-3-methoxyphenylboronic acid (0.75 g, 35% yield) was obtained as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, methanol-d4) with chemical shifts of δ 3.86 (s, 3H) and 7.03-7.45 (m, 3H).
References
[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71
4-FLUORO-3-METHOXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
View Lastest Price from 4-FLUORO-3-METHOXYPHENYLBORONIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-04-17 | 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |||
 |
2021-07-13 | 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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