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4-Fluoro-3-methoxyphenylboronic acid

4-Fluoro-3-methoxyphenylboronic acid Structure
4-Fluoro-3-methoxyphenylboronic acid structure
CAS No.
854778-31-7
Chemical Name:
4-Fluoro-3-methoxyphenylboronic acid
Synonyms
uoro-3-methoxyphenyL;Elagolix Impurity 50;5-Borono-2-fluoroanisole;4-Fluoro-3-Methoxyphenylboronic;4-Fluoro-5-methoxyphenylboronic acid;4-Fluoro-3-methoxyphenylboronic acid;4-FLUORO-3-METHOXYBENZENEBORONIC ACID;4-Fluoro-3-methoxybenzeneboronicacid98%;4-Fluoro-3-methoxybenzeneboronic acid 98%;Boronic acid, B-(4-fluoro-3-methoxyphenyl)-
CBNumber:
CB9237771
Molecular Formula:
C7H8BFO3
Molecular Weight:
169.95
MDL Number:
MFCD08056358
MOL File:
854778-31-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:19
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4-Fluoro-3-methoxyphenylboronic acid Properties

Melting point 189-191
Boiling point 318.1±52.0 °C(Predicted)
Density 1.26±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 8.19±0.10(Predicted)
color White to Almost white
InChI InChI=1S/C7H8BFO3/c1-12-7-4-5(8(10)11)2-3-6(7)9/h2-4,10-11H,1H3
InChIKey LUJMSRVFSBMEOY-UHFFFAOYSA-N
SMILES B(C1=CC=C(F)C(OC)=C1)(O)O
FDA UNII FW899DDX6U
UNSPSC Code 12352106

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  WGK 3
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT
HS Code  2931900090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
NFPA 704
0
2 0

4-Fluoro-3-methoxyphenylboronic acid price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F0919 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) 854778-31-7 1g $43 2026-04-30 Buy
TCI Chemical F0919 4-Fluoro-3-methoxyphenylboronic Acid (contains varying amounts of Anhydride) 854778-31-7 5g $141 2026-04-30 Buy
Apolloscientific PC5053 4-Fluoro-3-methoxybenzeneboronic acid 98% 854778-31-7 250mg $21 2026-06-04 Buy
Apolloscientific PC5053 4-Fluoro-3-methoxybenzeneboronic acid 98% 854778-31-7 1g $24 2026-06-04 Buy
Apolloscientific PC5053 4-Fluoro-3-methoxybenzeneboronic acid 98% 854778-31-7 5g $52 2026-06-04 Buy
Product number Packaging Price Buy
F0919 1g $43 Buy
F0919 5g $141 Buy
PC5053 250mg $21 Buy
PC5053 1g $24 Buy
PC5053 5g $52 Buy

4-Fluoro-3-methoxyphenylboronic acid Chemical Properties, Uses, Production

Uses

suzuki reaction

Synthesis

2-Fluoro-5-bromoanisole

103291-07-2

4-FLUORO-3-METHOXYPHENYLBORONIC ACID

854778-31-7

General procedure for the synthesis of 4-fluoro-3-methoxyphenylboronic acid from 2-fluoro-5-bromoanisole: To a solution of 2-fluoro-5-bromoanisole (2.7 g, 13.1 mmol) in tetrahydrofuran (THF, 25 mL) was slowly added n-butyllithium (n-BuLi, 1.6 M solution in hexane, 11.0 mL, 17.7 mmol) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 40 min, followed by the addition of trimethyl borate (2.7 mL, 24.3 mmol). The reaction system was slowly warmed from -78 °C to room temperature and stirring was continued at this temperature for 18 hours. Upon completion of the reaction, the reaction was quenched with 1.0 N hydrochloric acid (40 mL) and subsequently extracted with ethyl acetate (EtOAc). The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate (Na2SO4). After removal of solvent by evaporation under reduced pressure, the crude product obtained was purified by grinding with a solvent mixture of ethyl acetate/hexane (1:4, v/v). After filtration, the target product 4-fluoro-3-methoxyphenylboronic acid (0.75 g, 35% yield) was obtained as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, methanol-d4) with chemical shifts of δ 3.86 (s, 3H) and 7.03-7.45 (m, 3H).

References

[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 28
[2] Patent: US2007/3539, 2007, A1. Location in patent: Page/Page column 71

4-Fluoro-3-methoxyphenylboronic acid Preparation Products And Raw materials

Raw materials

2-Fluoro-5-bromoanisole Water n-Butyllithium Trimethyl borate Tetrahydrofuran
Hydrochloric acid Hexane

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Preparation Products

4-Fluoro-3-methoxyphenylboronic acid Suppliers

Global Suppliers ( 178)
Supplier Tel Email Country ProdList Advantage
Hangzhou Boloko Biotechnology Co., LTD 13757158499; 13757158499 bolokobiotech@qq.com China 4878 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
DKD Shijiazhuang Chemical Co., Ltd. 0311-67790228 15531158659 2361184479@qq.com China 300 62
Supplier Advantage
Hangzhou Boloko Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Beijing Ouhe Technology Co., Ltd 60
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
DKD Shijiazhuang Chemical Co., Ltd. 62

View Latest Price from 4-Fluoro-3-methoxyphenylboronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-FLUORO-3-METHOXYPHENYLBORONIC ACID pictures 2026-08-25 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
 $3.00-9.00 99% ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
4-FLUORO-3-METHOXYPHENYLBORONIC ACID pictures 2021-07-13 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-FLUORO-3-METHOXYPHENYLBORONIC ACID pictures 2021-07-10 4-FLUORO-3-METHOXYPHENYLBORONIC ACID
854778-31-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4-Fluoro-3-methoxyphenylboronic acid Spectrum

4-FLUORO-3-METHOXYPHENYLBORONIC ACID(854778-31-7)1HNMR

854778-31-7 (4-Fluoro-3-methoxyphenylboronic acid) Related Search:

4-Bromo-2-fluoro-6-methoxyphenylboronic acid 3-Methoxy-2,4,6-trifluorophenylboronic acid 3-(Benzyloxy)-4-fluorophenylboronic acid 3-Ethoxy-4-fluorobenzeneboronic acid 3-FLUORO-4-METHOXYPHENYLBORONIC ACID,3-Fluoro-4-methoxyphenylboronic acid ,98%
2-FLUORO-4-METHOXYPHENYLBORONIC ACID 4-FLUORO-2-METHOXYPHENYLBORONIC ACID 3-Bromo-6-fluoro-2-methoxyphenylboronic acid 2,3-Difluoro-4-methoxyphenylboronic acid 6-Bromo-3-fluoro-2-methoxyphenylboronic acid
2-FLUORO-6-METHOXYPHENYLBORONIC ACID 2-Fluoro-3-methoxyphenylboronic acid 3-Isopropoxy-2,4,6-trifluorobenzeneboronic acid 3-Butoxy-2,4,6-trifluorophenylboronic a& 2 6-Difluoro-4-methoxyphenylboronic acid
2,5-Difluoro-4-methoxyphenylboronic acid 3-Ethoxy-2,4,6-trifluorophenylboronic a& 4-Fluoro-3-methoxyphenylboronic acid

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Boronicacid, (4-fluoro-3-methoxyphenyl)- (9CI) BORONICACID, (4-FLUORO-3-METHOXYPHENYL)- (9CI); 5-Borono-2-fluoroanisole 4-Fluoro-3-Methoxyphenylboronic Acid (contains varying aMounts of Anhydride) 4-Fluoro-5-methoxyphenylboronic acid 4-Fluoro-3-Methoxyphenylboronic 4-Fluoro-3-methoxybenzeneboronic acid 98% 4-Fluoro-3-methoxybenzeneboronicacid98% 4-FLUORO-3-METHOXYBENZENEBORONIC ACID uoro-3-methoxyphenyL Boronic acid, B-(4-fluoro-3-methoxyphenyl)- Elagolix Impurity 50 4-Fluoro-3-methoxybenzeneboronic acid(contains varying amounts of Anhydride) 4-Fluoro-3-methoxyphenylboronic acid 854778-31-7 blocks BoronicAcids FluoroCompounds