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5-Amino-3-(trifluoromethyl)picolinonitrile

5-Amino-3-(trifluoromethyl)picolinonitrile structure

CAS No.: 573762-62-6

Chemical Name:: 5-Amino-3-(trifluoromethyl)picolinonitrile

Synonyms: 5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile;Apatamide intermediate;Apalutamide Impurity 19;5-Amino-3-(trifluoromethyl)2-cyanopyridine;5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE;5-AMino-3-(trifluroMethyl) picolinonitrile;2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine;5-Amino-2-cyano-3-(trifluoromethyl)pyridine;5-amino-3 - (trifluoromethyl) cyanopyridine;5-Amino-3-(trifluoromethyl)picolinonitrile 97%

CBNumber:: CB92611517

Molecular Formula:: C7H4F3N3

Molecular Weight:: 187.12

MDL Number:: MFCD17010171

MOL File:: 573762-62-6.mol

Last updated:2025-09-20 20:09:13

Product description	Number	Pack Size	Price
5-Amino-3-(trifluoromethyl)picolinonitrile 97%	PC53326	1g	$80
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile	FA103833	100mg	$80
5-Amino-3-(trifluoromethyl)picolinonitrile 97%	3H37-3-76	1g	$128
5-Amino-3-(trifluoromethyl)picolinonitrile 97%	PC53326	5g	$160
5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile	FA103833	250mg	$160
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5-Amino-3-(trifluoromethyl)picolinonitrile Properties

Boiling point	362.2±42.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	-1.52±0.10(Predicted)
Appearance	Off-white to yellow Solid
InChI	InChI=1S/C7H4F3N3/c8-7(9,10)5-1-4(12)3-13-6(5)2-11/h1,3H,12H2
InChIKey	WLMSCOVORZUSNW-UHFFFAOYSA-N
SMILES	C1(C#N)=NC=C(N)C=C1C(F)(F)F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H311+H331
Precautionary statements	P260-P280-P311
RIDADR	3439
HazardClass	6.1
PackingGroup	Ⅲ
HS Code	2933399990

5-Amino-3-(trifluoromethyl)picolinonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC53326	5-Amino-3-(trifluoromethyl)picolinonitrile 97%	573762-62-6	1g	$80	2021-12-16	Buy
Biosynth Carbosynth	FA103833	5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile	573762-62-6	100mg	$80	2021-12-16	Buy
SynQuest Laboratories	3H37-3-76	5-Amino-3-(trifluoromethyl)picolinonitrile 97%	573762-62-6	1g	$128	2021-12-16	Buy
Apolloscientific	PC53326	5-Amino-3-(trifluoromethyl)picolinonitrile 97%	573762-62-6	5g	$160	2021-12-16	Buy
Biosynth Carbosynth	FA103833	5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile	573762-62-6	250mg	$160	2021-12-16	Buy

Product number	Packaging	Price	Buy
PC53326	1g	$80	Buy
FA103833	100mg	$80	Buy
3H37-3-76	1g	$128	Buy
PC53326	5g	$160	Buy
FA103833	250mg	$160	Buy

5-Amino-3-(trifluoromethyl)picolinonitrile Chemical Properties,Uses,Production

Uses

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE is a pyridine heterocyclic organic compound, which can be used as pharmaceutical intermediates.

Synthesis

5-Nitro-3-trifluoroMethylpyridine-2-carbonitrile

573762-57-9

5-Amino-3-(trifluoromethyl)picolinonitrile

573762-62-6

General procedure for the synthesis of 5-amino-3-(trifluoromethyl)cyanopyridine from 2-cyano-5-nitro-3-(trifluoromethyl)pyridine: 2-cyano-3-(trifluoromethyl)-5-nitropyridine A10 (0.095 g, 0.44 mmol) was reacted with powdered iron (0.112 g, 2 mmol) in a mixed solvent of ethyl acetate (1 ml) and acetic acid (1 ml) The reaction was heated for 15 hours in a mixture of ethyl acetate (1ml) and acetic acid (1ml). After completion of the reaction, the solid particles were removed by diatomaceous earth filtration and the filtrate was concentrated. Finally, the target compound A11 (0.075 g, 0.4 mmol, 91% yield) was purified by column chromatography (eluent: EtOAc:pentane=1:1).

References

[1] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0040; 0047
[2] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 11; 12; 19
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 47-48
[4] Patent: US2016/152592, 2016, A1. Location in patent: Paragraph 0073; 0080; 0081
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2803 - 2806

5-Amino-3-(trifluoromethyl)picolinonitrile synthesis

Synthesis of 5-Amino-3-(trifluoromethyl)picolinonitrile from 5-Nitro-3-trifluoroMethylpyridine-2-carbonitrile

5-Amino-3-(trifluoromethyl)picolinonitrile Preparation Products And Raw materials

Raw materials

3-Trifluoromethylpyridine 2-Hydroxy-3-trifluoromethylpyridine 5-Nitro-3-trifluoroMethylpyridine-2-carbonitrile 3-(trifluoromethyl)pyridine 1-oxide 5-((4-Methoxybenzyl)amino)-3-(trifluoromethyl)picolinonitrile

6-Chloro-N-(4-methoxybenzyl)-5-(trifluoromethyl)pyridin-3-amine 3-(Trifluoromethyl)-2-pyridinecarbonitrile 5-IODO-3-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 2-CHLORO-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE

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Preparation Products

5-isothiocyanato-3-(trifluoromethyl)picolinonitrile

5-Amino-3-(trifluoromethyl)picolinonitrile Suppliers

Global( 283)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696 +8618018249389	sales@anikare.com	China	9942	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20175	58
Hebei Junhua Import and Export Co., LTD	+85259680964	junhua1@hb-junhua.com	China	933	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58

Supplier	Advantage
Changzhou AniKare Pharmatech Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Hebei Junhua Import and Export Co., LTD	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 5-Amino-3-(trifluoromethyl)picolinonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-10-17	5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 573762-62-6	US $0.00 / kg	1kg	97%	1000	Hebei Junhua Import and Export Co., LTD
2025-09-25	5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 573762-62-6	US $8.00-0.90 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2025-09-24	5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile 573762-62-6	US $0.00 / kg	1kg	99%	1000kg	Shanghai Joiny Pharmaceutical Co.,LTD

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE
573762-62-6
US $0.00 / kg
97%
Hebei Junhua Import and Export Co., LTD

5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE
573762-62-6
US $8.00-0.90 / KG
99%
Henan Fengda Chemical Co., Ltd

5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile
573762-62-6
US $0.00 / kg
99%
Shanghai Joiny Pharmaceutical Co.,LTD

5-Amino-3-(trifluoromethyl)picolinonitrile Spectrum

5-Amino-3-(trifluoromethyl)picolinonitrile(573762-62-6)¹HNMR

573762-62-6(5-Amino-3-(trifluoromethyl)picolinonitrile)Related Search:

1-Piperazinecarboxylic acid, 4-[3-fluoro-4-(methoxycarbonyl)phenyl]-, 1,1-dimethylethyl ester (2-(4-chlorophenyl)-4,4-diMethylcyclohex-1-enyl)Methanol Apalutamide 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile

methyl 2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(piperazin-1-yl)benzoate tert-butyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-bromobenzoate ABT-199 4-(1-CYANOCYCLOBUTYLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride

Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4-Bromo-2-fluoro-N-methylbenzamide

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5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 5-Amino-3-(trifluoromethyl)picolinonitrile 97% 5-AMino-3-(trifluroMethyl) picolinonitrile 5-AMino-3-(trifluoroMethyl)pyridine-2-carbonitrile 5-Amino-3-(trifluoromethyl)2-cyanopyridine 5-Amino-2-cyano-3-(trifluoromethyl)pyridine 5-amino-3-((trifluoromethyl))-pyridin-2-carbonitrile 5-Amino-3-(trifluoromethyl)-2-pyridinecarbonitrile 2-Pyridinecarbonitrile, 5-amino-3-(trifluoromethyl)- 5-Amino-3-(trifluoromethyl)pyridine-2-carbonitrile(For export only) 2-Cyano-3-(Trifluoromethyl)-5-Aminopyridine Apalutamide Impurity 19 5-amino-3 - (trifluoromethyl) cyanopyridine Apatamide intermediate 5-Amino-3-(trifluoromethyl) picolinonitrile/ Apalutamide intermediate 5-Amino-3-(trifluoromethyl)pyridinecarbonitrile 5-AMINO-3-(TRIFLUOROMETHYL)PICOLINONITRILE 98+ 573762-62-6 LG