4-Bromo-2,5-difluoronitrobenzene
- CAS No.
- 167415-27-2
- Chemical Name:
- 4-Bromo-2,5-difluoronitrobenzene
- Synonyms
- 1-BROMO-2,5-DIFLUORO-4-NITROBENZENE;BUTTPARK 29\01-58;4-Bromo-2,5-difluoronitrobenzene;2,5-Difluoro-4-bromonitrobenzene;5-Bromo-1,4-difluoro-2-nitrobenzene;4-Bromo-2,5-difluoronitrobenzene >Benzene, 1-bromo-2,5-difluoro-4-nitro-;4-BROMO-2,5-DIFLUORONITROBENZENE ISO 9001：2015 REACH
- CBNumber:
- CB9300651
- Molecular Formula:
- C6H2BrF2NO2
- Molecular Weight:
- 237.99
- MDL Number:
- MFCD00042184
- MOL File:
- 167415-27-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 55 °C |
|---|---|
| Boiling point | 262.4±35.0 °C(Predicted) |
| Density | 1.890±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | Light orange to Yellow to Green |
| BRN | 7411347 |
| CAS DataBase Reference | 167415-27-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H301-H311-H332-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, TOXIC | |||||||||
| HS Code | 29042090 | |||||||||
| NFPA 704 |
|
4-Bromo-2,5-difluoronitrobenzene price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B3926 | 4-Bromo-2,5-difluoronitrobenzene >98.0%(GC) | 167415-27-2 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | B3926 | 4-Bromo-2,5-difluoronitrobenzene >98.0%(GC) | 167415-27-2 | 5g | $89 | 2026-04-30 | Buy |
| Apolloscientific | PC8153 | 4-Bromo-2,5-difluoronitrobenzene ≥95% | 167415-27-2 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC8153 | 4-Bromo-2,5-difluoronitrobenzene ≥95% | 167415-27-2 | 5g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS34592 | 1-Bromo-2,5-difluoro-4-nitrobenzene 98% | 167415-27-2 | 5g | $26 | 2026-06-04 | Buy |
4-Bromo-2,5-difluoronitrobenzene Chemical Properties, Uses, Production
Chemical Properties
light yellow solid
Synthesis
399-94-0
167415-27-2
General procedure for the synthesis of 4-bromo-2,5-difluoronitrobenzene from 2,5-difluorobromobenzene: Referring to Example-50, a mixture of acids was prepared by cooling concentrated sulfuric acid (57 mL) in an ice bath, followed by the slow dropwise addition of 69% nitric acid (25.5 g, 279 mmol) over a period of 25 minutes. A dichloroethane (125 mL) solution of 2-bromo-1,4-difluorobenzene (50 g, 254 mmol) was added slowly dropwise over 1.5 h to the above mixed acid under ice bath cooling conditions. After the dropwise addition, the reaction mixture was continued to be stirred at room temperature for 2 hours. Upon completion of the reaction, the reaction solution was slowly poured into ice water (500 g) and extracted with ether (300 mL x 2). The organic phases were combined and washed sequentially with water (300 mL), saturated aqueous sodium bicarbonate solution (300 mL) and saturated saline (300 mL). The organic layer was dried over anhydrous magnesium sulfate and then distilled under reduced pressure to remove the solvent. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/chloroform=4:1) to afford 1-bromo-2,5-difluoro-4-nitrobenzene (56 g, yield: 93%) as a pale yellow solid.1H-NMR (400 MHz, CDCl3): δ 7.59 (dd, J=9.5 and 5.5 Hz, 1H), 7.89 (dd, J=7.3 and 6.5 Hz, 1H).19F-NMR (376 MHz, CDCl3): δ -120.1 (d, J=15.2 Hz, 1F), -107.9 (d, J=15.2 Hz, 1F).
References
[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0809; 0810
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0164; 0168
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0251
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 22, p. 4367 - 4379
[5] Journal of Organic Chemistry, 1995, vol. 60, # 18, p. 5838 - 5842
4-Bromo-2,5-difluoronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 4-Bromo-2,5-difluoronitrobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 4-BROMO-2,5-DIFLUORONITROBENZENE
167415-27-2
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-14 | 4-BROMO-2,5-DIFLUORONITROBENZENE
167415-27-2
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 4-BROMO-2,5-DIFLUORONITROBENZENE
167415-27-2
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-BROMO-2,5-DIFLUORONITROBENZENE
167415-27-2
- $1.00
- 99%
- Career Henan Chemical Co
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