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1-Bromo-2,4-difluoro-5-nitrobenzene

1-Bromo-2,4-difluoro-5-nitrobenzene structure

CAS No.: 345-24-4

Chemical Name:: 1-Bromo-2,4-difluoro-5-nitrobenzene

Synonyms: AURORA KA-7912;BUTTPARK 89\07-60;MCH-1 antagonist 2;4-DIFLUORO-5-NITROBENZENE;2,4-Difluoro-5-BroMonitrobenzene;2,4-Difluoro-5-nitrobroMobenzene;5-BROMO-2,4-DIFLUORONITROBENZENE;1-Bromo-2,4-difluoro-5-nitrobenzene;5-Bromo-2,4-difluoronitrobenzene 98%;Benzene, 1-broMo-2,4-difluoro-5-nitro-

CBNumber:: CB4776741

Molecular Formula:: C6H2BrF2NO2

Molecular Weight:: 237.99

MDL Number:: MFCD00129166

MOL File:: 345-24-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:58

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1-Bromo-2,4-difluoro-5-nitrobenzene Properties

Melting point	19°C(lit.)
Boiling point	85°C 0,4mm
Density	1.890±0.06 g/cm3(Predicted)
refractive index	1.5580 to 1.5620
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
InChI	InChI=1S/C6H2BrF2NO2/c7-3-1-6(10(11)12)5(9)2-4(3)8/h1-2H
InChIKey	OOUUWURPSUSDTD-UHFFFAOYSA-N
SMILES	C1(Br)=CC([N+]([O-])=O)=C(F)C=C1F
CAS DataBase Reference	345-24-4(CAS DataBase Reference)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H335-H315

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

WGK Germany

WGK 3

HazardClass

IRRITANT

HS Code

2904990090

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

1-Bromo-2,4-difluoro-5-nitrobenzene price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	KOB0017	1-Bromo-2,4-difluoro-5-nitrobenzene	345-24-4	1 g	$276	2026-04-30	Buy
TCI Chemical	B5688	1-Bromo-2,4-difluoro-5-nitrobenzene >98.0%(GC)	345-24-4	1g	$24	2026-04-30	Buy
TCI Chemical	B5688	1-Bromo-2,4-difluoro-5-nitrobenzene >98.0%(GC)	345-24-4	5g	$57	2026-04-30	Buy
Apolloscientific	PC10283	5-Bromo-2,4-difluoronitrobenzene 98%	345-24-4	5g	$21	2026-06-04	Buy
Apolloscientific	PC10283	5-Bromo-2,4-difluoronitrobenzene 98%	345-24-4	25g	$32	2026-06-04	Buy

Product number	Packaging	Price	Buy
KOB0017	1 g	$276	Buy
B5688	1g	$24	Buy
B5688	5g	$57	Buy
PC10283	5g	$21	Buy
PC10283	25g	$32	Buy

1-Bromo-2,4-difluoro-5-nitrobenzene Chemical Properties,Uses,Production

Uses

1-Bromo-2,4-difluoro-5-nitrobenzene is a nitrobenzene derivative containing fluorine and bromine atom substituents. It can be used as a pharmaceutical intermediate for the preparation of novel N2-phenylpyrimidine-2,4-diamine compounds showing effective inhibition of EGFR mutations, and thus can be effectively used in the treatment of EGFR-mutated cancers.

Synthesis

348-57-2

345-24-4

General procedure for the synthesis of 2,4-difluoro-5-bromonitrobenzene from 2,4-difluorobromobenzene: Concentrated HNO3 (34.0 mL) was added slowly and dropwise to a suspension of 1-bromo-2,4-difluorobenzene (53.0 mmol, 6.00 mL) in concentrated H2SO4 (38.5 mL) at 0 °C, ensuring that the internal temperature was maintained below 0 °C. The reaction mixture was stirred for 10 minutes with vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 10 min and subsequently poured into an ice/water mixture under vigorous stirring. The mixture was extracted with ether (ET20, 3 x 100 mL). The combined organic phases were washed sequentially with aqueous NaHCO3 (3 x 100 mL) and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by fast chromatography (eluent: EtOAc/hexane=1:9) to afford 5-bromo-2,4-difluoronitrobenzene as a yellow oil (12.2 g, 97% yield).1H NMR (400 MHz, CDCl3) δ 8.45 (t, 1H, J=7.5 Hz), 7.16 (dd, 1H, J=11.0,8.6 Hz) ; ESMS m/z: 240, 238, 223, 221, 112.

References

[1] Synthesis, 1998, # 8, p. 1101 - 1103
[2] Patent: WO2004/5257, 2004, A1. Location in patent: Page 67
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3870 - 3882
[4] Patent: US2005/154020, 2005, A1. Location in patent: Page/Page column 8
[5] Patent: US2005/154022, 2005, A1. Location in patent: Page/Page column 9

1-Bromo-2,4-difluoro-5-nitrobenzene synthesis

Synthesis of 1-Bromo-2,4-difluoro-5-nitrobenzene from 1-Bromo-2,4-difluorobenzene

1-Bromo-2,4-difluoro-5-nitrobenzene Preparation Products And Raw materials

Raw materials

1-Bromo-2,4-difluorobenzene Nitric acid Sulfuric acid

Preparation Products

6-Bromo-5-fluoroindolin-2-one

1-Bromo-2,4-difluoro-5-nitrobenzene Suppliers

Global( 145)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9513	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Changzhou Huanling Chemical Co., Ltd.	68
Accela ChemBio Co.,Ltd.	64
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
T&W GROUP	58
Shanghai Topbiochem Technology Co., Ltd	58

View Lastest Price from 1-Bromo-2,4-difluoro-5-nitrobenzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-02	1-Bromo-2,4-difluoro-5-nitrobenzene 345-24-4		10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2022-02-22	1-Bromo-2,4-difluoro-5-nitrobenzene 345-24-4		1KG	99.1%	100 tons	Honest Joy Holdings Limited
2019-07-06	1-BROMO-2,4-DIFLUORO-5-NITROBENZENE 345-24-4	$1.00	1KG	95%	500kg	Career Henan Chemical Co

1-Bromo-2,4-difluoro-5-nitrobenzene
345-24-4
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

1-Bromo-2,4-difluoro-5-nitrobenzene
345-24-4
$0.00
99.1%
Honest Joy Holdings Limited

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE
345-24-4
$1.00
95%
Career Henan Chemical Co

1-Bromo-2,4-difluoro-5-nitrobenzene Spectrum

1-BROMO-2,4-DIFLUORO-5-NITROBENZENE(345-24-4)¹HNMR 1-BROMO-2,4-DIFLUORO-5-NITROBENZENE(345-24-4)FT-IR

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BUTTPARK 89\07-60 AURORA KA-7912 5-BROMO-2,4-DIFLUORONITROBENZENE 2,4-Difluoro-5-nitrobroMobenzene 2,4-Difluoro-5-BroMonitrobenzene 5-Bromo-2,4-difluoronitrobenzene 98% Benzene, 1-broMo-2,4-difluoro-5-nitro- 4-DIFLUORO-5-NITROBENZENE MCH-1 antagonist 2 1-Bromo-2,4-difluoro-5-nitrobenzene 345-24-4 Halides Phenyls & Phenyl-Het Phenyls & Phenyl-Het