ChemicalBook >> CAS DataBase List >>Boc-trans-4-fluoro-L-proline methyl ester
Boc-trans-4-fluoro-L-proline methyl ester
- CAS No.
- 203866-18-6
- Chemical Name:
- Boc-trans-4-fluoro-L-proline methyl ester
- Synonyms
- (4R)-1-BOC-4-FLUORO-L-PROLINE METHYL ESTER;1-tert-butyl 2-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate;BOC-trans-4-Fluoroproline methyl ester;Boc-trans-4-fluoro-L-proline methyl ester;N-Boc-tran-4-Fluoro-L-proline Methyl ester;1-Boc-Trans-4-fluoro-L-proline Methyl ester;N-Boc-trans-4-fluoro-L-proline methyl ester;N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER;N-Boc-trans-4-fluoro-L-proline methyl ester 97%;(2S,4R)-N-Boc-trans-4-fluoro-L-proline methyl ester
- CBNumber:
- CB9314591
- Molecular Formula:
- C11H18FNO4
- Molecular Weight:
- 247.26
- MDL Number:
- MFCD07367993
- MOL File:
- 203866-18-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-09-12 18:56:22
| Melting point | 34-39 °C |
|---|---|
| Density | 1.16 |
| Flash point | 110 °C |
| storage temp. | 2-8°C |
| form | powder |
| Appearance | Colorless to off-white <36°C Solid,>39°C Liquid |
| optical activity | [α]22/D -80.0°, c = 1 in methanol |
| Water Solubility | Insoluble in water. |
| InChI | InChI=1S/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8+/m1/s1 |
| InChIKey | METPQQHVRNLTRX-SFYZADRCSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(OC)=O |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264b-P270-P280-P301+P312-P302+P352-P305+P351+P338-P330-P332+P313-P337+P313-P362+P364-P403-P501c | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Boc-trans-4-fluoro-L-proline methyl ester price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 702412 | N-Boc-trans-4-fluoro-L-proline methyl ester 97% | 203866-18-6 | 1g | $465 | 2026-04-30 | Buy |
| Sigma-Aldrich | 702412 | N-Boc-trans-4-fluoro-L-proline methyl ester 97% | 203866-18-6 | 250mg | $200 | 2023-06-20 | Buy |
| Biosynth | FB50550 | Boc-trans-4-fluoro-L-proline methyl ester | 203866-18-6 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FB50550 | Boc-trans-4-fluoro-L-proline methyl ester | 203866-18-6 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FB50550 | Boc-trans-4-fluoro-L-proline methyl ester | 203866-18-6 | 10g | $201.3 | 2026-06-04 | Buy |
Boc-trans-4-fluoro-L-proline methyl ester Chemical Properties, Uses, Production
Uses
N-Boc-trans-4-fluoro-L-proline methyl ester is used to prepare (S)-2-[N-(N'-benzyl-(S)-4-fluoro-L-prolyl)amino]benzophenone by reacting with of 2-aminobenzophenone in the presence of potassium tert -butoxide.
Synthesis
203866-14-2
74-88-4
203866-18-6
GENERAL STEPS: (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid (2 g, 8.57 mmol), potassium carbonate (5.9 g, 42.69 mmol), and THF (80 mL) were mixed, and methyl iodide (6.1 g, 42.98 mmol) was added, and the reaction was stirred for 12 hours at room temperature. After completion of the reaction, the solid was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel with EtOAc/petroleum ether (1:5) as eluent to afford N-BOC-trans-4-fluoro-L-proline methyl ester (800 mg, 38% yield) as a colorless oil.
References
[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0521; 0522; 01714; 01715
Synthesis of Boc-trans-4-fluoro-L-proline methyl ester from 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate and Iodomethane
Boc-trans-4-fluoro-L-proline methyl ester Preparation Products And Raw materials
Global Suppliers ( 138)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xinxin Pharmaceutical Technology Co., Ltd. | 13671725141 | hickle@yeah.net | China | 768 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
View Latest Price from Boc-trans-4-fluoro-L-proline methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-03 | BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
203866-18-6
|
$6.60 | 1KG | 97%-99% | 1kg -1000kg | Career Henan Chemical Co |
-
- BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
203866-18-6
- $6.60
- 97%-99%
- Career Henan Chemical Co
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1-Boc-Trans-4-fluoro-L-proline Methyl ester
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N-Boc-trans-4-fluoro-L-proline methyl ester 97%
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cid 2-Methyl Ester,99%e.e.
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1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)-
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER USP/EP/BP
BOC-trans-4-Fluoroproline methyl ester
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N-Boc-trans-4-fluoro-L -proline methyl ester
Methyl (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylate - [E13524]
(4R)-1-BOC-4-FLUORO-L-PROLINE METHYL ESTER
1-tert-butyl 2-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate
Boc-trans-4-fluoro-L-proline methyl ester
203866-18-6
C11H18FNO4
Asymmetric Synthesis
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Chemical Synthesis
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Pyrrolidines
