(S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 101410-18-8
- Chemical Name:
- (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- 1-Pyrrolidineca;1-N-Boc-thioprolinamide;N-Boc-thio-L-prolinamide;BOC-(S)-Pyrrolidine-2-Thiocarboxamide;(S)-1-Boc-pyrrolidine-2-carbothioamide;N-BOC-(S)-Pyrrolidine-2-thiocarboxamide;TERT-BUTYL2(S)-THIOCARBAMOYLPYRROLIDINE-1-CARBOXYLATE;tert-butyl (S)-2-carbamothioylpyrrolidine-1-carboxylate;(S)-tert-butyl 2-thiocarbaMoylpyrrolidine-1-carboxylate;tert-butyl (2S)-2-carbamothioylpyrrolidine-1-carboxylate
- CBNumber:
- CB5386725
- Molecular Formula:
- C10H18N2O2S
- Molecular Weight:
- 230.33
- MDL Number:
- MFCD06738835
- MOL File:
- 101410-18-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | J61419 | 250mg | $30 |
| (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | J61419 | 1g | $84 |
| (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | J61419 | 5g | $409 |
| (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 98% | B399 | 250mg | $42 |
| (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 98% | B399 | 1g | $117 |
| More product size | |||
| Melting point | 195-199 °C(Solv: tetrahydrofuran (109-99-9)) |
|---|---|
| Boiling point | 339.5±52.0 °C(Predicted) |
| Density | 1.191±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 12.98±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H18N2O2S/c1-10(2,3)14-9(13)12-6-4-5-7(12)8(11)15/h7H,4-6H2,1-3H3,(H2,11,15)/t7-/m0/s1 |
| InChIKey | KPAOKCBKJXBXNI-ZETCQYMHSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H]1C(N)=S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | J61419 | (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | 101410-18-8 | 250mg | $30 | 2026-06-04 | Buy |
| AK Scientific | J61419 | (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | 101410-18-8 | 1g | $84 | 2026-06-04 | Buy |
| AK Scientific | J61419 | (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 95% | 101410-18-8 | 5g | $409 | 2026-06-04 | Buy |
| AK Scientific | B399 | (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 98% | 101410-18-8 | 250mg | $42 | 2026-06-04 | Buy |
| AK Scientific | B399 | (S)-2-Thiocarbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester 98% | 101410-18-8 | 1g | $117 | 2026-06-04 | Buy |
(S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Synthesis
35150-07-3
117175-41-4
General procedure for the synthesis of tert-butyl (R)-2-thiocarboxamido pyrrolidine-1-carboxylate from N-tert-butoxycarbonyl-L-prolinamide: (S)-1-(tert-butoxycarbonyl)prolinamide (9.0 g, 42.0 mmol) and Lawesson's reagent (8.5 g, 21.0 mmol) were dissolved in anhydrous THF (55 mL) and the reaction was stirred for 3.5 hours at room temperature under nitrogen protection. The reaction was stirred at room temperature for 3.5 h under nitrogen protection. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Saturated aqueous NaHCO3 (100 mL) was added to the residue and stirring was continued for 1 hour. The aqueous phase suspension was extracted with EtOAc/CH2Cl2 (1:1, 400 mL), the organic phase was washed with saturated aqueous NaHCO3 solution (2 x 100 mL), and the combined aqueous phases were then extracted with EtOAc/CH2Cl2 (200 mL). All organic extracts were combined, dried with Na2SO4 and concentrated under reduced pressure to give tert-butyl (S)-2-thiocarbonylpyrrolidine-1-carboxylate as a white solid (8.74 g, 90% yield) with a melting point (EtOAc) of 190-192 °C. [α]D -103.4 (c 1.00, CHCl3). IR (KBr) 3380, 3202, 2981, 2881, 1671, 1411, 1166 cm-1. 1H NMR (400 MHz, CDCl3) δ= 1.41-1.50 (m, 9H), 1.65-2.75 (m, 4H), 3.22- 3.74 (m, 2H), 4.67 (dd, J = 8.0 and 3.6 Hz, 1H) ppm. HRMS (ESI) m/z calculated value C10H19N2O2S (M + H) 231.1162, measured value 231.1161.
References
[1] Journal of the American Chemical Society, 2002, vol. 124, # 6, p. 916 - 917
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 7, p. 2229 - 2233
[3] Tetrahedron Letters, 2011, vol. 52, # 42, p. 5435 - 5437
[4] Patent: US2011/65726, 2011, A1. Location in patent: Page/Page column 12
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 228 - 247
(S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-09 | (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
101410-18-8
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
101410-18-8
- $1.00
- 99%
- Career Henan Chemical Co
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