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ChemicalBook >> CAS DataBase List >>1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Structure
1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate structure
CAS No.
203866-14-2
Chemical Name:
1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
Synonyms
N-BOC-TRANS-4-FLUORO-L-PROLINE;N-T-BOC-TRANS-4-FLUORO-L-PROLINE;N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID;Boc-trans-4-F-Pro-OH;Boc-trans-4-fluoro-Pro-OH;BOC-TRANS-4-FLUORO-L-PROLINE;N-Boc-Tran-4-Fluoro-L-proline;1-BOC-Trans-4-fluoro-L-proline;(2R,4S)-N-BOC-4-FLUORO-D-PROLINE;(2S,4R)-N-Boc-trans-4-Fluoro-L-Proline
CBNumber:
CB2312240
Molecular Formula:
C10H16FNO4
Molecular Weight:
233.24
MDL Number:
MFCD06796085
MOL File:
203866-14-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:14:50
Request For Quotation

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Properties

Melting point 115-119°C
Boiling point 346.0±42.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
refractive index -69 ° (C=1, MeOH)
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 3.53±0.40(Predicted)
color White to Almost white
optical activity [α]22/D -65.0±5°, c = 1 in chloroform
InChI InChI=1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1
InChIKey YGWZXQOYEBWUTH-RQJHMYQMSA-N
SMILES N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(O)=O
CAS DataBase Reference 203866-14-2(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 687332 N-Boc-trans-4-fluoro-L-proline 97% 203866-14-2 500mg $230 2026-04-30 Buy
TCI Chemical B3177 (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >96.0%(GC)(T) 203866-14-2 1g $175 2026-04-30 Buy
TCI Chemical B3177 (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >96.0%(GC)(T) 203866-14-2 200mg $53 2026-04-30 Buy
Usbiological 458406 N-Boc-trans-4-fluoro-L-proline 203866-14-2 500mg $347 2026-06-03 Buy
Usbiological 458406 N-Boc-trans-4-fluoro-L-proline 203866-14-2 2.5g $460 2026-06-03 Buy
Product number Packaging Price Buy
687332 500mg $230 Buy
B3177 1g $175 Buy
B3177 200mg $53 Buy
458406 500mg $347 Buy
458406 2.5g $460 Buy

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Chemical Properties, Uses, Production

Synthesis

Synthesis of 203866-14-2

Step 1) Synthesis of Compound 9-2

Compound 9-1 (11.0 g, 44.8 mmol) was dissolved in DCM (200 mL). Et2NSF3 (8.85 mL, 67.3 mmol) was slowly added dropwise at -78 °C. After the addition was complete, the reaction was kept at a constant temperature for 2.0 hours, and then reacted at room temperature for 19 hours.

After the reaction was complete, ammonium chloride aqueous solution (100 mL) was added to quench the reaction. The aqueous layer was extracted with DCM (100 mL × 3). The organic phases were combined, washed with saturated brine, dried over anhydrous Na2SO4, concentrated, and purified by column chromatography (eluent: PE/EtOAc(v/v) = 20/1) to obtain 7.75 g of pale yellow liquid, yield: 70%.

Step 2) Synthesis of compound 9-3

Compound 9-2 (5.83 g, 23.6 mmol) was dissolved in THF (30 mL). At 0 °C, an aqueous solution of lithium hydroxide (1.98 g, 30 mL) was slowly added dropwise. After the addition was complete, the reaction was allowed to proceed at room temperature for 2.0 hours. After the reaction was complete, the pH of the reaction solution was adjusted to 5 with dilute hydrochloric acid (1M). After removing THF, the pH of the aqueous layer was adjusted to 2 with dilute hydrochloric acid (1M). The solution was extracted with EtOAc (80mL×3). The organic phases were combined, washed with saturated brine, dried over anhydrous Na2SO4, and concentrated to give 5.27g of white solid. Yield: 96%.

Chemical Properties

White powder

Uses

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate synthesis

203866-18-6
203866-14-2
Synthesis of 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate from Boc-trans-4-fluoro-L-proline methyl ester

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Preparation Products And Raw materials

Raw materials

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2S,4R)- Boc-trans-4-fluoro-L-proline methyl ester

Preparation Products

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Suppliers

Global Suppliers ( 228)
Supplier Tel Email Country ProdList Advantage
SHANGHAI INSPO CHEMICAL CO.,LTD 18917565227 inspo@inspochem.com China 631 58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd. 13671725141 hickle@yeah.net China 768 58
Shanghai joygo pharmacetical tech., Co., Ltd. 13621615409 sale1@joygooo.com China 108 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
SHANGHAI INSPO CHEMICAL CO.,LTD 58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd. 58
Shanghai joygo pharmacetical tech., Co., Ltd. 50
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-t-BOC-trans-4-Fluoro-L-Proline pictures 2026-08-25 N-t-BOC-trans-4-Fluoro-L-Proline
203866-14-2
 $2.20-8.80 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-BOC-trans-4-fluoro-L-proline pictures 2026-01-04 N-BOC-trans-4-fluoro-L-proline
203866-14-2
 $1400.00 98 % 500 Kg R&D Scientific Inc.
BOC-TRANS-4-FLUORO-L-PROLINE pictures 2024-02-26 BOC-TRANS-4-FLUORO-L-PROLINE
203866-14-2
 1kg 98% BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate Spectrum

BOC-TRANS-4-FLUORO-L-PROLINE(203866-14-2)1HNMR

203866-14-2 (1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate) Related Search:

Nr (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid N-BOC-cis-4-fluoro-L-proline Cbz-D-Valine
Boc-trans-4-fluoro-L-proline methyl ester Boc-trans-4-fluoro-5-oxo-L-proline methyl ester L-Proline D-Proline N-Boc-cis-4-Fluoro-D-Proline
BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER N-BOC-4,4-difluoro-L-proline 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate

1of3

N-BOC-(4S,2R)-4-FLUORO-2-PYRROLIDINECARBOXYLIC ACID N-(TERT-BUTOXYCARBONYL)-(2S,4R)-4-FLUOROPROLINE BOC-TRANS-4-FLUORO-L-PROLINE (2S,4R)-N-Boc-trans-4-Fluoro-L-Proline (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N4-BOC protected trans-4-Fluoro-L-proline, N-BOC protected (2S,4R)-Boc-4-fluoro-pyrrolidine-2-carboxylic acid (2R,4S)-N-BOC-4-FLUORO-D-PROLINE (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid, N-BOC protected (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline (2S,4R)-4-FLUORO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (2R,4S)-N-Boc-trans-4-Fluoro-D-proline methyl ester (2R,4S)-N-Boc-trans-4-Fluoro-D-proline trans-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylicacid N-Boc-Tran-4-Fluoro-L-proline Boc-trans-4-fluoro-Pro-OH (2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline N-Boc-trans-4-fluoro-L-proline 1-BOC-Trans-4-fluoro-L-proline (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylic acid (2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboyxlic acid (2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4R)-4-Fluoro-1,2-pyrrolidinedicarboxylic Acid tert-B utyl Ester 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) ester, (2S,4R)- (2S,4R)-N-Boc-4-fluoropyrrolidine-2-carboxy lic acid (2S,4R)-1-(tert-Dutoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid > (2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylicaci BOC-TRANS-4-FLUORO-L-PROLINE USP/EP/BP TIANFU CHEM --BOC-TRANS-4-FLUORO-L-PROLINE Boc-trans-4-F-Pro-OH 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate 1-(tert-Butyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate N-Boc-trans-4-fluoro-L-proline N-BOC-(2S,4R)-4-fluoro-2-pyrrolidinecarboxylic acid N-BOC-TRANS-4-FLUORO-L-PROLINE N-T-BOC-TRANS-4-FLUORO-L-PROLINE 203866-14-2 Carboxylic Acids (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Chiral Building Blocks Heterocyclic Building Blocks Pyrrolidines