ChemicalBook >> CAS DataBase List >>N-Boc-4,4-difluoro-L-proline methyl ester

N-Boc-4,4-difluoro-L-proline methyl ester

N-Boc-4,4-difluoro-L-proline methyl ester structure

CAS No.: 203866-17-5

Chemical Name:: N-Boc-4,4-difluoro-L-proline methyl ester

Synonyms: N-Boc-4,4-Difluoro-L<;BOC-L-PRO(4,4-DIFLUORO)-OME;Methyl (S)-1-Boc-4,4-difl...;BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER;N-Boc-4,4-difluoro-L-proline methyl ester;N-T-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER;N-Boc-4,4-Difluoro-L-proline Methyl ester 97%;(2S)-N-Boc-4,4-difluoro-L-proline methyl ester;N-Boc-4,4-difluoro-L-proline Methyl Ester,99%e.e.;BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER USP/EP/BP

CBNumber:: CB2324050

Molecular Formula:: C11H17F2NO4

Molecular Weight:: 265.25

MDL Number:: MFCD03094918

MOL File:: 203866-17-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:19:30

Request For Quotation

N-Boc-4,4-difluoro-L-proline methyl ester Properties

Melting point	41-46 °C
Boiling point	293℃
Density	1.22
Flash point	110 °C
storage temp.	2-8°C
pka	-8.00±0.60(Predicted)
form	White to off-white crystalline powder
Appearance	White to light yellow Solid
Major Application	peptide synthesis
InChI	InChI=1S/C11H17F2NO4/c1-10(2,3)18-9(16)14-6-11(12,13)5-7(14)8(15)17-4/h7H,5-6H2,1-4H3/t7-/m0/s1
InChIKey	RQDZKOOUQIDZOG-ZETCQYMHSA-N
SMILES	N1(C(OC(C)(C)C)=O)CC(F)(F)C[C@H]1C(OC)=O
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Boc-4,4-difluoro-L-proline methyl ester price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	702463	N-Boc-4,4-Difluoro-L-proline methyl ester 97%	203866-17-5	1g	$494	2026-04-30	Buy
Apolloscientific	PC409002	N-t-BOC-4,4-Difluoro-L-Proline Methyl Ester >98%	203866-17-5	250mg	$21	2026-06-04	Buy
Apolloscientific	PC409002	N-t-BOC-4,4-Difluoro-L-Proline Methyl Ester >98%	203866-17-5	1g	$24	2026-06-04	Buy
Apolloscientific	PC409002	N-t-BOC-4,4-Difluoro-L-Proline Methyl Ester >98%	203866-17-5	5g	$55	2026-06-04	Buy
Apolloscientific	PC409002	N-t-BOC-4,4-Difluoro-L-Proline Methyl Ester >98%	203866-17-5	25g	$262	2026-06-04	Buy

Product number	Packaging	Price	Buy
702463	1g	$494	Buy
PC409002	250mg	$21	Buy
PC409002	1g	$24	Buy
PC409002	5g	$55	Buy
PC409002	25g	$262	Buy

N-Boc-4,4-difluoro-L-proline methyl ester Chemical Properties, Uses, Production

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

102195-80-2

203866-17-5

General procedure for the synthesis of N-BOC-4,4-difluoro-L-proline methyl ester from BOC-4-oxo-L-proline methyl ester: Intermediate 5a (300 g, 1.23 mmol, 1.00 eq.) was dissolved in dichloromethane (30 mL) at 0 °C, and DAST (1.80 g, 11.2 mmol, 9.00 eq.) was slowly added dropwise to the dichloromethane (10 mL) solution. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was washed sequentially with saturated aqueous sodium bicarbonate solution (1 x 30 mL) and brine (3 x 30 mL). The organic layer was separated, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give Intermediate 5b (300 mg, 92% yield) as a yellow oil.

References

[1] Patent: WO2006/123257, 2006, A2. Location in patent: Page/Page column 70
[2] Patent: WO2013/96771, 2013, A1. Location in patent: Page/Page column 95
[3] Journal of the American Chemical Society, 2016, vol. 138, # 7, p. 2443 - 2453
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 17, p. 7589 - 7613
[5] Patent: WO2005/23762, 2005, A1. Location in patent: Page/Page column 72

N-Boc-4,4-difluoro-L-proline methyl ester Preparation Products And Raw materials

Raw materials

N-BOC-4,4-difluoro-L-proline N-Boc-4-oxo-L-Proline methyl ester Iodomethane Dichloromethane Diethylaminosulfur trifluoride

Preparation Products

(S)-N-(2-(2-cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide 4,4-Difluoro-L-proline Methyl ester trifluoroacetate N-BOC-4,4-difluoro-L-proline

N-Boc-4,4-difluoro-L-proline methyl ester Suppliers

Global Suppliers ( 141)

Supplier	Tel	Email	Country	ProdList	Advantage
SANBEM Biotech (Suzhou) Co., Ltd.	0512-85667806 18551283436;400-965-3330	sales@sanbem.com	China	3018	58
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	823	55
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58

Supplier	Advantage
SANBEM Biotech (Suzhou) Co., Ltd.	58
BTC Pharmaceutical CO. Ltd	55
Shanghai Boyle Chemical Co., Ltd.	55
Alfa Aesar	84
Energy Chemical	61
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Daicel Chiral Technologies (China)CO.,LTD	65
Shanghai Topbiochem Technology Co., Ltd	58

View Latest Price from N-Boc-4,4-difluoro-L-proline methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-02-26	1-O-tert-butyl 2-O-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate 203866-17-5		1kg	98%		BTC Nantong Pharmaceuticals Technology Co.,Ltd

1-O-tert-butyl 2-O-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate
203866-17-5
98%
BTC Nantong Pharmaceuticals Technology Co.,Ltd

N-Boc-4,4-difluoro-L-proline methyl ester Spectrum

BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER(203866-17-5)¹HNMR

203866-17-5 (N-Boc-4,4-difluoro-L-proline methyl ester) Related Search:

L-Tryptophan BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER N-trans-BOC-(3S)-Fluoropyrrolidine N-BOC-4,4-difluoro-L-proline Boc-L-Proline-methyl ester

N-BOC-cis-4-fluoro-L-proline (S)-3-Fluoro-pyrrolidine Methyl (2S,4R)-4-fluoroprolinate Boc-trans-4-fluoro-L-proline methyl ester 2-(2,2-Difluoro-propylamino)-ethanol

3,3-Difluoropyrrolidine hydrochloride 1-(1,1-Dimethylethyl) (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate (2S,4R)-4-Fluoropyrrolidine-2-carboxylic acid 1-Boc-3,3-difluoropyrrolidine (2S,4S)-4-Fluoro-pyrrolidine-2-carboxylic acid

(2S,4S)-4-Fluoro-2-methoxycarbonyl-pyrrolidine HCl N-Boc-alpha-methyl-L-proline L-Proline, 4,4-difluoro- (9CI)

1of4

N-Boc-4,4-Difluoro-L-proline Methyl ester 97% Methyl (S)-1-Boc-4,4-difl... 1,2-Pyrrolidinedicarboxylicacid, 4,4-difluoro-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)- Methyl 1-(tert-butoxycarbonyl)-4,4-difluoropyrrolidine-(2S)-carboxylate 1-tert-Butyl 2-methyl (S)-4,4-difluoropyrrolidine-1,2-dicarboxylate Methyl (S)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1-tert-butyl 2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate N-Boc-4,4-Difluoro-L-proline methyl ester N-Boc-4,4-difluoro-L-proline Methyl Ester,99%e.e. BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER BOC-L-PRO(4,4-DIFLUORO)-OME N-T-BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER N-Boc-4,4-difluoro-L-proline methyl ester 1-tert-Butyl 2-methyl (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate, tert-Butyl (2S)-2-(methoxycarbonyl)-4,4-difluoropyrrolidine-1-carboxylate 1-tert-Butyl 2-methyl (2S)-4,4-difluoro-1,2-pyrrolidinedicarboxylate tert-Butyl (2S)-2-(methoxycarbonyl)-4,4-difluoropyrrolidine-1-carboxylate (S)-4,4-Difluoro-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester O1-tert-butyl O2-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate 1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate 1-O-tert-butyl 2-O-methyl (2S)-4,4-difluoropyrrolidine-1,2-dicarboxylate 1-(tert-butyl) 2-methyl (S)-4,4-difluoropyrrolidine-1,2-dica BOC-4,4-DIFLUORO-L-PROLINE METHYL ESTER USP/EP/BP (2S)-N-Boc-4,4-difluoro-L-proline methyl ester N-Boc-4,4-Difluoro-L< N-Boc-4,4-Difluoro-L-proline methyl ester 203866-17-5 C11H17F2NO4