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2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile structure

CAS No.: 13600-42-5

Chemical Name:: 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

Synonyms: 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile;BUTTPARK 43\57-39;IFLAB-BB F2108-0099;2,6-Dichloro-4-(Trifluoromethy;,6-Dichloro-4-(trifluoromethyl)nicotinonitrile;2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE;3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine;3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE;2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98%;3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98%

CBNumber:: CB9351572

Molecular Formula:: C7HCl2F3N2

Molecular Weight:: 241

MDL Number:: MFCD00084977

MOL File:: 13600-42-5.mol

MSDS File:: SDS

Last updated:2026-05-28 05:31:41

Product description	Number	Pack Size	Price
3-Cyano-2,6-dichloro-4-trifluoromethylpyridine	425216	1g	$319
3-Cyano-2,6-dichloro-4-trifluoromethylpyridine	425216	5g	$439
3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	270269	2g	$333
3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	270269	5g	$496
3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	270269	10g	$674
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2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Properties

Melting point	38 °C
Boiling point	282.4±35.0 °C(Predicted)
Density	1.63±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	crystals
pka	-6.82±0.10(Predicted)
color	Colourless
CAS DataBase Reference	13600-42-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	T,Xi,Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	22-26-36/37/39
RIDADR	3439
HazardClass	TOXIC
HS Code	2933399990

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	425216	3-Cyano-2,6-dichloro-4-trifluoromethylpyridine	13600-42-5	1g	$319	2026-06-03	Buy
Usbiological	425216	3-Cyano-2,6-dichloro-4-trifluoromethylpyridine	13600-42-5	5g	$439	2026-06-03	Buy
Usbiological	270269	3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	13600-42-5	2g	$333	2026-06-03	Buy
Usbiological	270269	3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	13600-42-5	5g	$496	2026-06-03	Buy
Usbiological	270269	3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine Asreported	13600-42-5	10g	$674	2026-06-03	Buy

Product number	Packaging	Price	Buy
425216	1g	$319	Buy
425216	5g	$439	Buy
270269	2g	$333	Buy
270269	5g	$496	Buy
270269	10g	$674	Buy

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Chemical Properties,Uses,Production

Chemical Properties

yellow powder

Uses

3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is used as a reagent in the synthesis of cyano(trifluoromethyl)aminopyridine derivatives which are used as androgen receptor antagonists for stimulating hair growth and reducing sebum production. 3-Cyano-2,6-dichloro-4-trifluoromethylpyridine is also used in the preparation of novel analogs of marine indole alkaloids which are used as potential anticancer agents.

Synthesis

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

3335-46-4

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile

13600-42-5

GENERAL STEPS: In a 500 mL round bottom flask, 84.5 g (414 mmol) of 2,6-dihydroxy-3-cyano-4-(trifluoromethyl)pyridine, 400 g of phosphoryl chloride and 35 g of catalyst were added. The mixture was heated and refluxed for 20 h, during which the progress of the reaction was monitored by TLC. Upon completion of the reaction, the reflux unit was changed to a distillation unit to evaporate the excess phosphorus trichloride. The reaction mixture was slowly poured into an ice-water mixture and a white solid was precipitated. The solid was collected by filtration and dried to give 79.6 g of the target product 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine in 79.78% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 475 - 477
[2] Patent: CN107382848, 2017, A. Location in patent: Paragraph 0043; 0046-0047

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Preparation Products And Raw materials

Raw materials

3-CYANO-2,6-DIHYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE

Preparation Products

4-(Trifluoromethyl)nicotinic acid 2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE 4-(TRIFLUOROMETHYL)NICOTINAMIDE 4-(Trifluoromethyl)nicotinonitrile

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Suppliers

Global( 180)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1444	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	280	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Hangzhou Cyanochem Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Fuxin Pharmaceutical	58
SIMAGCHEM CORP	58

View Lastest Price from 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-25	2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5	$1.10	1g	99.0% min	100 tons min	Shaanxi Dideu Medichem Co. Ltd
2021-10-16	2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5	$10.00	1KG	99%	20 Tons	Hebei Zhanyao Biotechnology Co. Ltd
2019-12-31	2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 13600-42-5	$1.00	1KG	99%	10000KGS	Career Henan Chemical Co

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
$1.10
99.0% min
Shaanxi Dideu Medichem Co. Ltd

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
$10.00
99%
Hebei Zhanyao Biotechnology Co. Ltd

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile
13600-42-5
$1.00
99%
Career Henan Chemical Co

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile Spectrum

2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile(13600-42-5)¹HNMR 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile(13600-42-5)¹HNMR 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile(13600-42-5)¹⁹FNMR 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile(13600-42-5)¹³CNMR

13600-42-5(2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile)Related Search:

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3-Cyano-2,6-dichloro-4-(trifluoomethyl)pyridine 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 98% 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine 2,6-dichloro-4-((trifluoromethyl))-pyridin-3-carbonitrile 2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINONITRILE 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine, 2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile 3-CYANO-2,6-DICHLORO-4-(TRIFLUOROMETHYL)PYRIDINE IFLAB-BB F2108-0099 BUTTPARK 43\57-39 2,6-Dichloro-4-(Trifluoromethy 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine 98% 3-Cyano-2,6-dichloro-4-(trifluoromethyl)pyridine98% 2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile 3-Pyridinecarbonitrile, 2,6-dichloro-4-(trifluoromethyl)- 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile ISO 9001：2015 REACH ,6-Dichloro-4-(trifluoromethyl)nicotinonitrile 2,6-Dichloro-4-(trifluoromethyl)-3-pyridinecarbonitrile 2,6-Dichloro-4-(trifluoromethyl)nicotinonitrile?New 13600-42-5 C7HCl2F3N2 cyanide| alkyl chloride Pyridine Pyridine series Pyridines