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2-Methoxypyridine-5-boronic acid pinacol ester

2-Methoxypyridine-5-boronic acid pinacol ester structure

CAS No.: 445264-61-9

Chemical Name:: 2-Methoxypyridine-5-boronic acid pinacol ester

Synonyms: 2-methoxyl-5-pyridineboronic acid pinacol ester;2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-(-2-Methoxypyridin-5-yl) Pyridine;2-Methoxypyridine-5-boronic acid pinacoL;6-Methoxy-pyridine-3-boronic acid picol ester;6-Methoxy-3-pyridylboronic Acid Pinacol Ester;2-Methoxypyridine-5-boronic acid pinacol ester;6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER;(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester

CBNumber:: CB9367724

Molecular Formula:: C12H18BNO3

Molecular Weight:: 235.09

MDL Number:: MFCD05663858

MOL File:: 445264-61-9.mol

MSDS File:: SDS

Last updated:2026-09-12 18:56:27

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2-Methoxypyridine-5-boronic acid pinacol ester Properties

Melting point	47-51 °C(lit.)
Boiling point	102°C/0.08mmHg(lit.)
Density	1.06±0.1 g/cm3(Predicted)
Flash point	216 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Water Solubility	Soluble in water
form	powder to crystal
pka	3.39±0.12(Predicted)
color	White to Almost white
InChI	1S/C12H18BNO3/c1-11(2)12(3,4)17-13(16-11)9-6-7-10(15-5)14-8-9/h6-8H,1-5H3
InChIKey	QOGNDJLSYMJGPP-UHFFFAOYSA-N
SMILES	COc1ccc(cn1)B2OC(C)(C)C(C)(C)O2
CAS DataBase Reference	445264-61-9(CAS DataBase Reference)
UNSPSC Code	12352103

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/38

Safety Statements

WGK Germany

HS Code

2933399990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2

NFPA 704

	0
2		0

2-Methoxypyridine-5-boronic acid pinacol ester price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	636029	2-Methoxypyridine-5-boronic acid pinacol ester 97%	445264-61-9	1g	$32	2023-06-20	Buy
Sigma-Aldrich	636029	2-Methoxypyridine-5-boronic acid pinacol ester 97%	445264-61-9	5g	$152	2023-01-07	Buy
TCI Chemical	M2650	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)	445264-61-9	1g	$35	2026-04-30	Buy
TCI Chemical	M2650	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)	445264-61-9	5g	$139	2026-04-30	Buy
Usbiological	159675	(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester	445264-61-9	1g	$418	2026-06-03	Buy

Product number	Packaging	Price	Buy
636029	1g	$32	Buy
636029	5g	$152	Buy
M2650	1g	$35	Buy
M2650	5g	$139	Buy
159675	1g	$418	Buy

2-Methoxypyridine-5-boronic acid pinacol ester Chemical Properties, Uses, Production

Uses

2-Methoxypyridine-5-boronic acid pinacol ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.

Uses

(2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester is used in the design and synthesis of oxazolidinone antibacterial agents. As well, it is used in the synthesis of [3,2-b]pyridines.

Synthesis

13472-85-0

73183-34-3

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER

445264-61-9

Step 1: 5-bromo-2-methoxypyridine (55 g, 0.29 mol), pinacol ester of bisboronic acid (90 g, 0.35 mol), potassium acetate (57 g, 0.58 mol) and bis(triphenylphosphine)palladium(II) chloride (2.2 g, 3 mmol) were dissolved in anhydrous dioxane (500 mL) under nitrogen protection. The reaction mixture was heated and stirred at 108 °C overnight. Upon completion of the reaction, the mixture was concentrated and purified by column chromatography using hexane/ethyl acetate as eluent to afford pinacol ester of 6-methoxypyridine-3-boronic acid (58 g, 84% yield).

References

[1] Patent: US9249156, 2016, B2. Location in patent: Page/Page column 36
[2] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 26; 28
[3] Patent: WO2014/186035, 2014, A1. Location in patent: Page/Page column 151
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 12, p. 2496 - 2500
[5] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6477 - 6485

2-Methoxypyridine-5-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 5-Bromo-2-methoxypyridine Bis(pinacolato)diboron 1,4-Dioxane Bis(triphenylphosphine)palladium(II) chloride

Potassium Acetate

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Preparation Products

2-Methoxypyridine-5-boronic acid pinacol ester Suppliers

Global Suppliers ( 194)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 13913916777	cfzhang@aikonchem.com	China	19902	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	55

View Latest Price from 2-Methoxypyridine-5-boronic acid pinacol ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-08-13	2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9		1G	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2021-07-13	2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 445264-61-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
$1.10
99.00%
Dideu Industries Group Limited

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
$0.00
98%
Shenzhen Nexcon Pharmatechs Ltd.

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER
445264-61-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Methoxypyridine-5-boronic acid pinacol ester Spectrum

2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER(445264-61-9)¹HNMR

445264-61-9 (2-Methoxypyridine-5-boronic acid pinacol ester) Related Search:

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Methyl acrylate 4-Methoxyphenylacetone 3-Pyridylboronic acid 3-(Methoxymethoxy)benzaldehyde 2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-Benzyloxypyridine-5-boronic acid, pinacol ester 2-(Cyclopropylmethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

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2-METHOXY-5-PYRIDINEBORONIC ACID, PINACOL ESTER 6-METHOXYPYRIDINE-3-BORONIC ACID, PINACOL ESTER (2-Methoxypyridin-5-yl)boronic Acid Pinacol Ester 2-Methoxy-5-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine (2-Methoxy-5-pyridineboronic acid pinacol ester) 2-Methoxy-5-pyridineboronic acid pinacol ester, 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 6-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Methoxy-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine 6-Methoxy-pyridine-3-boronic acid picol ester 2-Methoxyl-5-pyridineboronic acid pinacol ester 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Methoxypyridine-5-boronic acid pinacol ester 97% 2-(6-Methoxypyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolan 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine > 2-Methoxypyridine-5-boronic acid pinacoL Pyridine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-(6-Methoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 6-Methoxy-3-pyridylboronic Acid Pinacol Ester 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER ISO 9001：2015 REACH 2-(-2-Methoxypyridin-5-yl) Pyridine 2-Methoxypyridine-5-boronic acid pinacol ester,2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine - [M23718] 2-methoxyl-5-pyridineboronic acid pinacol ester 2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-Methoxypyridine-5-boronic acid pinacol ester 445264-61-9 408502-23-9 Boronic Acids and Derivatives Boronate Esters Organometallic Reagents Heteroaryl Boronic Ester CHIRAL CHEMICALS