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N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine structure

CAS No.: 166815-96-9

Chemical Name:: N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine

Synonyms: tert-Butyl 4-((tosyloxy)Methyl)piperidine-1-carboxylate;N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine; 166815-96-9;tert-Butyl 4-((tosyloxy);1-Boc-4-(tosyloxyMethyl)piperidine;1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine;1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE;1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96%;1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96%;N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)

CBNumber:: CB9423172

Molecular Formula:: C18H27NO5S

Molecular Weight:: 369.48

MDL Number:: MFCD05864740

MOL File:: 166815-96-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:56:28

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N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine Properties

Melting point	74-76℃
Boiling point	487.8±18.0 °C(Predicted)
Density	1.174±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	-1.94±0.40(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C18H27NO5S/c1-14-5-7-16(8-6-14)25(21,22)23-13-15-9-11-19(12-10-15)17(20)24-18(2,3)4/h5-8,15H,9-13H2,1-4H3
InChIKey	DARTVAOOTJKHQW-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(COS(C2=CC=C(C)C=C2)(=O)=O)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B4759	1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine >98.0%(N)	166815-96-9	5g	$40	2026-04-30	Buy
TCI Chemical	B4759	1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine >98.0%(N)	166815-96-9	25g	$191	2026-04-30	Buy
TRC	TRC-B809553-50MG	tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate	166815-96-9	50mg	$91	2026-06-03	Buy
TRC	TRC-B809553-10MG	tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate	166815-96-9	10mg	$72	2026-06-03	Buy
TRC	TRC-B809553-100MG	tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate	166815-96-9	100mg	$109	2026-06-03	Buy

Product number	Packaging	Price	Buy
B4759	5g	$40	Buy
B4759	25g	$191	Buy
TRC-B809553-50MG	50mg	$91	Buy
TRC-B809553-10MG	10mg	$72	Buy
TRC-B809553-100MG	100mg	$109	Buy

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine Chemical Properties, Uses, Production

Uses

tert-Butyl 4-((tosyloxy)methyl)piperidine-1-carboxylate is a useful intermediate used in the preparation of biologically active molecules with pharmacological applications.

Synthesis

98-59-9

123855-51-6

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE

166815-96-9

Example 1A Synthesis of tert-butyl 4-((tolylenesulfonyloxy)methyl)piperidine-1-carboxylate: N-BOC-4-piperidine methanol (10 g, 46.5 mmol) and triethylamine (5.64 g, 55.8 mmol) were dissolved in dichloromethane (100 mL) under nitrogen protection and cooled to 0°C. Subsequently, p-toluenesulfonyl chloride (9.73 g, 51.2 mmol) and 4-dimethylaminopyridine (1.13 g, 9.3 mmol) were slowly added to the solution. The reaction mixture was stirred at 17°C for 2 hours. After completion of the reaction, the reaction was quenched by the addition of water (100 mL). The aqueous layer was extracted with dichloromethane (100 mL x 2). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. Purification by column chromatography afforded 1-N-Boc-4-(4-methylbenzenesulfonyl oxymethyl)piperidine (17 g, 99% yield) as a white solid.LCMS (ESI) m/z: 370 (M + 1).

References

[1] Patent: US2017/29430, 2017, A1. Location in patent: Paragraph 0255
[2] Patent: CN105315267, 2016, A. Location in patent: Paragraph 0033; 0049
[3] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 107-108; 168-169; 210-211
[4] Patent: WO2012/168349, 2012, A1. Location in patent: Page/Page column 37
[5] Patent: US2013/34504, 2013, A1. Location in patent: Paragraph 0147; 0148; 0149

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine synthesis

Synthesis of N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine from Triethylenediamine and 2-methylpentane and Tosyl chloride and N-Boc-4-piperidinemethanol

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine Preparation Products And Raw materials

Raw materials

N-BOC-piperidine-4-carboxylic acid N-Boc-4-piperidinemethanol Tosyl chloride 4-Dimethylaminopyridine Dichloromethane

Triethylenediamine 4-Piperidinemethanol Di-tert-butyl dicarbonate p-Toluenesulfonic acid 2-methylpentane

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Preparation Products

tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine Suppliers

Global Suppliers ( 166)

Supplier	Tel	Email	Country	ProdList	Advantage
SanoChem (Chengdu) Tech. Co., Ltd.	28-87999436 02887999436	sales@sano-chem.com	China	3792	55
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Carbott PharmTech Inc.	0535-6385396	info@carbottpharm.com	China	996	56
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7881	64
Jinan Trio PharmaTech Co., Ltd.	0531-88811783	sales@trio-pharmatech.com	China	1856	62

Supplier	Advantage
SanoChem (Chengdu) Tech. Co., Ltd.	55
Shanghai Hobor Chemical Co., Ltd	60
Anhui Dexinjia Biopharm Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Carbott PharmTech Inc.	56
Pure Chemistry Scientific Inc.	62
Tetranov Biopharm	64
Jinan Trio PharmaTech Co., Ltd.	62

View Latest Price from N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-30	N-tert-Butoxycarbonyl -4-(4-toluenesulfonyloxymethyl) 166815-96-9	$500.00		NLT 98%	2MT per month	Anhui Dexinjia Biopharm Co., Ltd
2025-12-05	N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9		1kg	99.9	3 tons	Hefei TianRui Pharmaceutical Chemical Co., Ltd.
2024-10-31	N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 166815-96-9	$10.00	10g	0.99	1ton	Yangzhou Qinyuan Pharmatech Co.,ltd

N-tert-Butoxycarbonyl -4-(4-toluenesulfonyloxymethyl)
166815-96-9
$500.00
NLT 98%
Anhui Dexinjia Biopharm Co., Ltd

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
166815-96-9
$0.00
99.9
Hefei TianRui Pharmaceutical Chemical Co., Ltd.

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE
166815-96-9
$10.00
0.99
Yangzhou Qinyuan Pharmatech Co.,ltd

N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine Spectrum

N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE(166815-96-9)¹HNMR

166815-96-9 (N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine) Related Search:

N-Boc-ethylenediamine hydrochloride 1-N-Boc-3-fluoro-aniline 1-N-Boc-4-(4-bromophenyl)piperidine 6-tert-Butoxycarbonylamino-3-oxo-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester 1-Boc-4-methylpiperidine-4-carboxylic acid

1-N-Boc-4-(Phenylamino)piperidine 1-Boc-4-methanesulfonyloxymethyl-piperidine p-Toluenesulfonic acid (S)-2-methylbutyl ester N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine

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tert-butyl 4-{[(4-methylbenzenesulfonyl)oxy]methyl}piperidine-1-carboxylate 4-[(4-methylphenyl)sulfonyloxymethyl]-1-piperidinecarboxylic acid tert-butyl ester 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylic acid tert-butyl ester tert-Butyl 4-((tosyloxy) 1-PIPERIDINECARBOXYLIC ACID, 4-[[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, 1,1-DIMETHYLETHYL ESTER N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine95% N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl) 1-piperidinecarboxylic acid, 4-[[[(4-methylphenyl)sulfonyl tert-butyl 4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate 1-N-bOC-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 1-Boc-4-(p-toluenesulfonyloxyMethyl)piperidine, 96% 1-Boc-4-(tosyloxyMethyl)piperidine 4-[[(4-Tolylsulfonyl)oxy]methyl]piperidine-1-carboxylic acid tert-butyl ester N-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine N-tert-Butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine 166815-96-9 1-(tert-Butoxycarbonyl)-4-[(p-toluenesulfonyloxy)methyl]piperidine> 1-N-BOC-4-(4-Methylbenzenesulfonyloxymethyl)piperidine 1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine,96% 1-(tert-Butoxycarbonyl)-4-(tosyloxymethyl)piperidine N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidi... 1-Boc-4-(p-toluenesulfonyloxymethyl)piperidine N-Boc-4-(4-toluenesulfonyloxymethyl)piperidine tert-Butyl 4-((tosyloxy)Methyl)piperidine-1-carboxylate N-tert-Butoxycarbonyl-4-(4-toluenesulfonyloxymethyl)piperidine 166815-96-9