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2-Chloronicotinamide

2-Chloronicotinamide Structure
2-Chloronicotinamide structure
CAS No.
10366-35-5
Chemical Name:
2-Chloronicotinamide
Synonyms
2-Chloronicotimide;TIMTEC-BB SBB004012;RARECHEM AH CK 0070;2-CHLORONICOTINAMIDE;2-CHLORONICOTINALDEHYDE;Nicotinamide, 2-chloro-;2-Chloronicotinamide 98%;2-Chloronicotinamide >2-CHLORONICOTINAMIDE CNAM;2-Chloronicotinamide, 98+%
CBNumber:
CB9449716
Molecular Formula:
C6H5ClN2O
Molecular Weight:
156.57
MDL Number:
MFCD00006237
MOL File:
10366-35-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:53:46
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2-Chloronicotinamide Properties

Melting point 164-167 °C(lit.)
Boiling point 313.7±27.0 °C(Predicted)
Density 1.4411 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. Inert atmosphere,Room Temperature
pka 14.19±0.50(Predicted)
form Fine Crystalline Powder
color Beige
BRN 119026
InChI InChI=1S/C6H5ClN2O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,8,10)
InChIKey ZQZAHPFFZWEUCL-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC=C1C(N)=O
CAS DataBase Reference 10366-35-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29333990
NFPA 704
1
2 0

2-Chloronicotinamide price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C1404 2-Chloronicotinamide >98.0%(GC) 10366-35-5 5g $35 2026-04-30 Buy
TCI Chemical C1404 2-Chloronicotinamide >98.0%(GC) 10366-35-5 25g $116 2026-04-30 Buy
Activate Scientific AS22366 2-Chloronicotinamide 98% 10366-35-5 5g $20 2026-06-04 Buy
Apolloscientific OR1214 2-Chloronicotinamide 98% 10366-35-5 1g $21 2026-06-04 Buy
Apolloscientific OR1214 2-Chloronicotinamide 98% 10366-35-5 5g $24 2026-06-04 Buy
Product number Packaging Price Buy
C1404 5g $35 Buy
C1404 25g $116 Buy
AS22366 5g $20 Buy
OR1214 1g $21 Buy
OR1214 5g $24 Buy

2-Chloronicotinamide Chemical Properties, Uses, Production

Chemical Properties

BEIGE FINE CRYSTALLINE POWDER

Uses

2-Chloronicotinamide is an off-white gracile crystal powder and serves as an important drug intermediate. 2-Chloronicotinamide acts as a substrate and precursor to produce 2-chloronicotinic acid through amidase-mediated hydrolysis and biocatalytic processes. 2-Chloronicotinamide is applied as a precursor in the synthesis of 2-piperazin-1-ylnicotinamide, 2-chloropyridine-3-carbothioamide, and 2-chloro-N-iso-butylnicotinamide[6-8].

Synthesis

2-Chloro-3-cyanopyridine

6602-54-6

2-Chloronicotinamide

10366-35-5

General procedure for the synthesis of 2-chloronicotinamide from 2-chloro-3-cyanopyridine: 400 mL of concentrated sulfuric acid was added to a 1000 mL three-necked flask, followed by the addition of 2-chloro-3-cyanopyridine (138 g, 1 mol), which was stirred until completely dissolved. The reaction system was warmed up to 90 °C and the reaction was maintained at this temperature with stirring for 2 hours. Upon completion of the reaction, the reaction mixture was slowly poured into a mixture containing 1000 mL of ammonia and 1 kg of ice and stirring was continued for 1 hour. The precipitated crude product was collected by filtration. The crude product was transferred to 1000 mL of ethyl acetate and stirred for 1 hour to wash and subsequently separated by filtration to give a white solid product. Finally, the white solid was dried by blowing at 50 °C to give 153 g of the intermediate 2-chloronicotinamide as a white solid in 98% yield.

References

[1] Patent: CN105367571,  2017,  B. Location in patent: Paragraph 0014; 0037; 0038
[2] Tetrahedron Letters,  2012,  vol. 53,  # 4,  p. 449 - 452
[3] Journal of Chemical Research,  2011,  vol. 35,  # 8,  p. 480 - 483
[4] Synlett,  2018,  vol. 29,  # 15,  p. 2061 - 2065
[5] Journal of Organic Chemistry,  1954,  vol. 19,  p. 1633,1636
[6] Tang, X.-L., Jin, J.-Q., Wu, Z.-M., Jin, L.-Q., Zheng, R.-C., Zheng, Y.-G. (2019). Structure-Based Engineering of Amidase from Pantoea sp. for Efficient 2-Chloronicotinic Acid Biosynthesis. Applied and Environmental Microbiology, 85(5). https://doi.org/10.1128/aem.02471-18
[7] Zheng, R.-C., Jin, J.-Q., Wu, Z.-M., Tang, X.-L., Jin, L.-Q., Zheng, Y.-G. (2018). Biocatalytic hydrolysis of chlorinated nicotinamides by a superior AS family amidase and its application in enzymatic production of 2-chloronicotinic acid. Bioorganic Chemistry, 76, 81–87. https://doi.org/10.1016/j.bioorg.2017.11.001
[8] He, H., Zhang, J., Niu, X., Wan, B., Lv, M., Li, F., Gao, X., Wan, Y., Yu, Y. (2025). Solubility determination, molecular simulation and thermodynamic analysis of 2-chloronicotinamide in three binary solvents from 278.15 K to 328.15 K. Journal of Molecular Liquids, 422, 126929. https://doi.org/10.1016/j.molliq.2025.126929

2-Chloronicotinamide synthesis

6602-54-6
10366-35-5
Synthesis of 2-Chloronicotinamide from 2-Chloro-3-cyanopyridine

2-Chloronicotinamide Preparation Products And Raw materials

Raw materials

Ethyl 2-chloronicotinate Nicotinamide 2-Chloronicotinyl chloride Nicotinamide-N-oxide 2-Chloronicotinic acid
2-Chloro-3-cyanopyridine

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Preparation Products

2-Chloro-3-cyanopyridine 3-Pyridinecarboxamide,1,2-dihydro-2-oxo-(9CI)

2-Chloronicotinamide Suppliers

Global Suppliers ( 216)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59

View Latest Price from 2-Chloronicotinamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloronicotinamide pictures 2026-08-20 2-Chloronicotinamide
10366-35-5
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Chloronicotinamide pictures 2021-10-15 2-Chloronicotinamide
10366-35-5
 $10.00 1KG 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2-Chloronicotinamide pictures 2021-07-13 2-Chloronicotinamide
10366-35-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Chloronicotinamide Spectrum

2-Chloronicotinamide(10366-35-5)MS2-Chloronicotinamide(10366-35-5)1HNMR2-Chloronicotinamide(10366-35-5)13CNMR2-Chloronicotinamide(10366-35-5)IR12-Chloronicotinamide(10366-35-5)IR22-Chloronicotinamide(10366-35-5)Raman

10366-35-5 (2-Chloronicotinamide) Related Search:

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RARECHEM AH CK 0070 TIMTEC-BB SBB004012 2-CHLORONICOTINAMIDE 2-CHLORO-PYRIDIN-3-CARBOXYLIC ACID AMIDE 2-CHLOROPYRIDINE-3-CARBOXAMIDE 2-CHLORONICOTINAMIDE CNAM 2-CHLORO-NICOTINAMIDE, 2-CHLORO-PYRIDIN-3-CARBOXYLIC ACID AMIDE 97% 2-CHLORO-NICOTINAMIDE, 2-CHLORO-PYRIDINE-3-CARBOXYLIC ACID AMIDE 2-CHLORONICOTINALDEHYDE 2-Chloronicotinamide, 98+% 3-Pyridinecarboxamide, 2-chloro- 2-Chloro-3-pyridinecarboxamide 2-Chloro-pyridine-3-carboxylic acid amide Nicotinamide, 2-chloro- 2-Chloronicotinamide 98% 2-Chloronicotinamide > 2-Chloronicotinamide ISO 9001：2015 REACH 2-Chloronicotimide 2-Chloropyridin-3-carboxamide 10366-35-5 Halopyridines Chloropyridines Pyridines Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles amine|alkyl chloride C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Chloropyridines Halopyridines