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2-Bromo-5-fluoropyridine

2-Bromo-5-fluoropyridine Structure
2-Bromo-5-fluoropyridine structure
CAS No.
41404-58-4
Chemical Name:
2-Bromo-5-fluoropyridine
Synonyms
5-FLUOROPYRIDINE-2-BORONIC ACID;EOS-60511;2-bromo-5-fluoropyr;2-bromo-5-fluoropyridin;2-BroMo-5-floropyridine;2-BoMo-5-fluoropyridine;5-Fluoro-2-broMopyridine;2-BROMO-5-FLUOROPYRIDINE;3-Fluoro-6-bromopyridine;2--5- fluoropyridinebroMide
CBNumber:
CB9683345
Molecular Formula:
C5H3BrFN
Molecular Weight:
175.99
MDL Number:
MFCD00234011
MOL File:
41404-58-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:41:30
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2-Bromo-5-fluoropyridine Properties

Melting point 30-31 °C (lit.)
Boiling point 80-83 °C/44 mmHg (lit.)
Density 1.707±0.06 g/cm3(Predicted)
refractive index 1.5396
Flash point 167 °F
storage temp. Inert atmosphere,Room Temperature
form Liquid
pka -1.63±0.10(Predicted)
color Colorless to slightly yellow
BRN 1561456
InChI InChI=1S/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H
InChIKey UODINHBLNPPDPD-UHFFFAOYSA-N
SMILES C1(Br)=NC=C(F)C=C1
CAS DataBase Reference 41404-58-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn,F
Risk Statements  36/37/38-20/21/22-10
Safety Statements  26-36-16
RIDADR  2811
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Bromo-5-fluoropyridine price More Price(99)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 595675 2-Bromo-5-fluoropyridine 97% 41404-58-4 5g $88.7 2026-04-30 Buy
Sigma-Aldrich 595675 2-Bromo-5-fluoropyridine 97% 41404-58-4 1g $25 2023-06-20 Buy
TCI Chemical B2799 2-Bromo-5-fluoropyridine >98.0%(GC) 41404-58-4 5g $36 2026-04-30 Buy
TCI Chemical B2799 2-Bromo-5-fluoropyridine >98.0%(GC) 41404-58-4 25g $176 2026-04-30 Buy
Usbiological 261715 2-Bromo-5-fluoropyridine Asreported 41404-58-4 5g $333 2026-06-03 Buy
Product number Packaging Price Buy
595675 5g $88.7 Buy
595675 1g $25 Buy
B2799 5g $36 Buy
B2799 25g $176 Buy
261715 5g $333 Buy

2-Bromo-5-fluoropyridine Chemical Properties, Uses, Production

Chemical Properties

Light yellow Cryst

Uses

2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.

Uses

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

  • 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
  • 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid
It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Synthesis

2-Amino-5-fluoropyridine

21717-96-4

2-Bromo-5-fluoropyridine

41404-58-4

Example C Synthesis of 2-bromo-5-fluoropyridine: 2-Amino-5-fluoropyridine (6.5 g, 58 mmol) was added in batches to 48% hydrobromic acid (28.8 mL, 296 mmol) cooled to 0-5 °C. A solution formed from bromine (8.9 mL, 174 mmol) and sodium nitrite (10 g, 145 mmol) dissolved in 20 mL of water was added slowly and dropwise at 0-5 °C (note: nitrogen release). The reaction mixture was stirred for 1 hour and then quenched with concentrated hydrochloric acid. A 32% sodium hydroxide solution (50.5 mL, 0.55 mol) was then added. The reaction mixture was continued to be stirred for 20 minutes at room temperature and then extracted three times with ether. The combined organic phases were washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure at 30 °C and 500 mbar (note: the product is volatile). The crude product was purified by rapid chromatography on silica gel with an elution gradient of dichloromethane/pentane (0:100 → 50:50). The final product was 2-bromo-5-fluoropyridine (6.7 g, 66% yield) in light yellow solid form.

References

[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 29
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0268
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 19, p. 5349 - 5352

2-Bromo-5-fluoropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-fluoropyridine Sodium nitrite Hydrogen bromide Sodium hydroxide

Preparation Products

2-Cyano-5-fluoropyridine GNE-495 5-Fluoro-2-iodopyridine 5-Fluoro-2-hydroxymethyl pyridine Ethyl 5-fluoropyridine-2-carboxylate
4-(5-Fluoro-2-pyridinyl)benzeneMethanol 1-(5-Fluoropyridin-2-yl)ethanone

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2-Bromo-5-fluoropyridine Suppliers

Global Suppliers ( 528)
Supplier Tel Email Country ProdList Advantage
Ningbo Fuhe Chemical Co., Ltd. 0574-1806900 18069001216 nbfjj@126.com China 99 58
Beijing DeLee Pharma Technology Co.,Ltd. 17316103847 sales@deleepharma.com China 234 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Supplier Advantage
Ningbo Fuhe Chemical Co., Ltd. 58
Beijing DeLee Pharma Technology Co.,Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
INTATRADE GmbH 66
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57

View Latest Price from 2-Bromo-5-fluoropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-fluoropyridine pictures 2026-09-02 2-Bromo-5-fluoropyridine
41404-58-4
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Bromo-5-fluoropyridine pictures 2026-03-20 2-Bromo-5-fluoropyridine
41404-58-4
 $8.90 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Bromo-5-fluoropyridine pictures 2025-06-25 2-Bromo-5-fluoropyridine
41404-58-4
 $1.10 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd

2-Bromo-5-fluoropyridine Spectrum

2-Bromo-5-fluoropyridine(41404-58-4)MS2-Bromo-5-fluoropyridine(41404-58-4)1HNMR2-Bromo-5-fluoropyridine(41404-58-4)13CNMR2-Bromo-5-fluoropyridine(41404-58-4)IR12-Bromo-5-fluoropyridine(41404-58-4)IR2

41404-58-4 (2-Bromo-5-fluoropyridine) Related Search:

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2-Bromo-5-fluoropyrimidine 2-Bromo-5-methylpyridine 2-Bromo-6-(trifluoromethyl)pyridine 2-Bromo-6-methylpyridine 2-Bromo-5-nitropyridine
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2-BROMO-5-FLUOROPYRIDINE 2--5- fluoropyridinebroMide 2-BroMo-5-fluoropyridine, 97+% 2 - broMine - 5 - fluoride pyridine 5-FLUOROPYRIDIN-2-YL-BORONIC ACID 2-bromo-5-fluoropyridin 2-Bromo-5-fluoropyridine98% 5-Fluoro-2-broMopyridine 2-BoMo-5-fluoropyridine 2-BroMo-5-fluoropyridine, 98% 1GR 2-BroMo-5-floropyridine 3-Fluoro-6-bromopyridine EOS-60511 2-bromo-5-fluoropyr 2-Bromo-5-fluoropyridine > Pyridine, 2-bromo-5-fluoro- 2-Bromo-5-fluoropyridine ISO 9001：2015 REACH 5-FLUOROPYRIDINE-2-BORONIC ACID 41404-58-4 21404-58-4 41404-58-2 Building Blocks Bromopyridines Halopyridines Fluoropyridines Halogenated Heterocycles Heterocyclic Building Blocks Pyridines Fluorine series Fluorinated Organohalides Bromopyridines Fluoropyridines Halopyridines Boronic Acid C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Variety of halogenated heterocyclic series Pyridine series blocks Bromides FluoroCompounds Pyridines Pyridine Pyridines, Pyrimidines, Purines and Pteredines Fluorin-contained pyridine series bc0001 41404-58-4