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1-Boc-4-cyanopiperidine

1-Boc-4-cyanopiperidine structure

CAS No.: 91419-52-2

Chemical Name:: 1-Boc-4-cyanopiperidine

Synonyms: TERT-BUTYL 4-CYANOPIPERIDINE-1-CARBOXYLATE;tert-Butyl 4-Cyano-1-piperidinecarboxylate;4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-4-cyanopiperid;Boc-4-cyanopiperidine;N-Boc-4-cyanopyridine;N-boc-4-cyanopiperidie;1-Boc-4-cynopiperidine;1-BOC-4-CYANOPIPERIDINE;N-Boc 4-cyano piperdine

CBNumber:: CB9684610

Molecular Formula:: C11H18N2O2

Molecular Weight:: 210.27

MDL Number:: MFCD01861223

MOL File:: 91419-52-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

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1-Boc-4-cyanopiperidine Properties

Melting point	60-63 °C
Boiling point	325.3±35.0 °C(Predicted)
Density	1.07±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform
pka	-3.08±0.40(Predicted)
form	Crystalline Powder
color	White to off-white
InChI	InChI=1S/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-7H2,1-3H3
InChIKey	UQADQTBQNVARAP-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C#N)CC1
CAS DataBase Reference	91419-52-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS09,GHS06,GHS07

Signal word

Warning

Hazard statements

H312-H331-H301+H311+H331-H315-H302-H319-H400

Precautionary statements

P273-P305+P351+P338-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501-P280h-P304+P340-P311a-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,N

Risk Statements

20/21/22-50-36-22

Safety Statements

36-36/37/39-61-26

RIDADR

3439

WGK Germany

Hazard Note

Harmful

HazardClass

6.1

PackingGroup

III

HS Code

29333990

Storage Class

11 - Combustible Solids

REACH Registrations

Active

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
2		0

1-Boc-4-cyanopiperidine price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	696447	N-Boc-piperidine-4-carbonitrile 97%	91419-52-2	1g	$70.6	2026-04-30	Buy
TCI Chemical	B3962	1-tert-Butoxycarbonyl-4-cyanopiperidine >97.0%(GC)	91419-52-2	1g	$47	2026-04-30	Buy
TCI Chemical	B3962	1-tert-Butoxycarbonyl-4-cyanopiperidine >97.0%(GC)	91419-52-2	5g	$164	2026-04-30	Buy
Usbiological	261680	N-Boc-4-cyanopiperidine Asreported	91419-52-2	50g	$694	2026-06-03	Buy
Usbiological	261680	N-Boc-4-cyanopiperidine Asreported	91419-52-2	100g	$1062	2026-06-03	Buy

Product number	Packaging	Price	Buy
696447	1g	$70.6	Buy
B3962	1g	$47	Buy
B3962	5g	$164	Buy
261680	50g	$694	Buy
261680	100g	$1062	Buy

1-Boc-4-cyanopiperidine Chemical Properties, Uses, Production

Chemical Properties

1-Boc-4-cyanopiperidine is a yellowish oil,it is flammable, it reacts with oxidizing agents.

Uses

Reactant for synthesis of:

Aminomethylated fluoropiperidines
Protein kinase B inhibitors
GlyT1 inhibitors
Piperidinecarboxylic acids via nitrilase-catalyzed enantioselective synthesis

Reactant for

Replacement in CB2 receptor inhibitors
Double addition reactions of methyllithium and n-butyllithium to unsaturated nitriles

Application

1-Boc-4-cyanopiperidine is an important intermediate mainly used in pharmaceuticals and organic synthesis.

Synthesis

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE

91419-48-6

91419-52-2

The general procedure for the synthesis of N-Boc-4-cyanopiperidine from tert-butyl 4-carbamoylpiperidine-1-carboxylate is as follows: to a solution of ethyl acetate (EtOAc, 1 mL, 1 M) containing an aldoxime or amide (1.0 mmol) and triethylamine (Et3N, 1.5 mmol) was added batchwise to XtalFluor-E (1.1 mmol) at room temperature. ). The reaction mixture was stirred at room temperature for 1 hour. Subsequently, the reaction was quenched with saturated sodium bicarbonate (NaHCO3) solution and extracted with aqueous sodium carbonate (Na2CO3) and dichloromethane (CH2Cl2, 2 × 10 mL). The combined organic layers were washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to give the crude product. If necessary, the crude product can be purified by fast column chromatography.

References

[1] Synthesis (Germany), 2015, vol. 47, # 23, p. 3758 - 3766
[2] Patent: WO2004/2483, 2004, A1. Location in patent: Page/Page column 21-22; 39-40
[3] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 12, p. 1503 - 1507
[4] European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 181 - 186
[5] Chemical and Pharmaceutical Bulletin, 2001, vol. 49, # 7, p. 822 - 829

1-Boc-4-cyanopiperidine synthesis

Synthesis of 1-Boc-4-cyanopiperidine from 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde

1-Boc-4-cyanopiperidine Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Isonipecotamide Di-tert-butyl dicarbonate Phosphorus oxitrichloride Chloroform

Isonipecotic acid Thionyl chloride 1-Boc-4-methanesulfonyloxypiperidine 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-piperidine-4-carboxylic acid

4-(Methylsulfonyl)benzonitrile 1-Piperidinecarboxylic acid,4-[(hydroxyimino)methyl]-,1,1-dimethylethyl ester tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxylate 1-N-Boc-4-bromopiperidine N-BOC-4-Hydroxypiperidine

4-Cyanopiperidine Tosyl cyanide

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Preparation Products

tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

1-Boc-4-cyanopiperidine Suppliers

Global Suppliers ( 408)

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
AstaTech(Chengdu) Biopharmaceutical Corp.	028-82666846 18080826311	sales@astatech.com.cn	China	499	58
SHANGHAI HOHANCE CHEMICAL CO.,LTD	021-31115312 18217084087	mary@hohance.com	China	170	62
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
Chengdu Firster Pharmaceutical Co., Ltd.	60
Shanghai Hobor Chemical Co., Ltd	60
AstaTech(Chengdu) Biopharmaceutical Corp.	58
SHANGHAI HOHANCE CHEMICAL CO.,LTD	62
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Chembest Research Laboratories Limited	61
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 1-Boc-4-cyanopiperidine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	1-Boc-4-cyanopiperidine 91419-52-2	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	1-Boc-4-cyanopiperidine 91419-52-2	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-05-20	1-Boc-4-cyanopiperidine 91419-52-2	1KG	99.0%min GC	20-40tons/year	AstaTech(Chengdu) Biopharmaceutical Corp.

1-Boc-4-cyanopiperidine
91419-52-2
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

1-Boc-4-cyanopiperidine
91419-52-2
98%
Henan Aochuang Chemical Co.,Ltd.

1-Boc-4-cyanopiperidine
91419-52-2
99.0%min GC
AstaTech(Chengdu) Biopharmaceutical Corp.

1-Boc-4-cyanopiperidine Spectrum

1-Boc-4-cyanopiperidine(91419-52-2)¹HNMR

91419-52-2 (1-Boc-4-cyanopiperidine) Related Search:

Butyl acetate Cyhalofop-butyl RESMETHRIN Haloperidol Diisobutyl phthalate

4-Cyanopiperidine Methyl cyanoformate Isobutyl chloroformate tert-Butyl carbazate Methylene dithiocyanate

Buprofezin Sodium cyanoborohydride 2-Butoxyethanol tert-Butyl peroxybenzoate Ethyl cyanoformate

Butyl acrylate tert-Butanol Ethyl 2-cyanoacrylate

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1-Piperidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester Boc-4-cyanopiperidine 1-BOC-PIPERIDINE-4-CARBONITRILE N-Boc-piperidine-4-carbonitrile N-boc-4-cyanopiperidie 1-Boc-4-cyanopiperid N-tert-Butoxycarbonyl-4-cyanopiperidine 1-N-Boc-4-cyano-piperidine ,98% 1-tert-Butoxycarbonyl-4-cyanopiperidine tert-Butyl 4-cyanopiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)piperidine-4-carbonitrile 1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate 4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester N-BOC-4-CYANO-PIPERIDINE 1-N-BOC-4-CYANO-PIPERIDINE 1-N-BOC-PIPERIDINE-4-CARBONITRILE 1-BOC-4-CYANOPIPERIDINE 4-CYANOPIPERIDINE, N-BOC PROTECTED 1-tert-Butoxycarbonyl-4-cyanopiperidine > N-Boc-piperidine-4-carbonitriL 1-Boc-4-piperidinecarbonitrile 1-tert-Butoxycarbonyl-4-piperidinecarbonitrile 4-Cyano-1-piperidinecarboxylic Acid tert-Butyl Ester t-Butyl 4-cyanopiperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-cyano-, 1,1-dimethylethyl ester (9CI, ACI) 4-cyano-1-Piperidinecarboxylic acid 1,1-dimethylethyl ester (9CI ACI) N-Boc 4-cyano piperdine 1-Boc-4-cynopiperidine N-Boc-piperidine-4-carbonitrile tert-butyl 3-cyanopiperidine-2-carboxylate tert-Butyl 4-cyanopiperidin-1-carboxylate 4-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 4-Cyano-1-piperidinecarboxylate TERT-BUTYL 4-CYANOPIPERIDINE-1-CARBOXYLATE N-Boc-4-cyanopyridine 91419-52-2 91419-53-4 Heterocyclic Building Blocks pharmacetical Pyrans, Piperidines &Piperazines Piperidine Piperazine Aromatics Pyrans, Piperidines & Piperazines Boron, Nitrile, Thio,& TM-Cpds Heterocycles