Isobutaneboronic acid
- CAS No.
- 84110-40-7
- Chemical Name:
- Isobutaneboronic acid
- Synonyms
- ISOBUTYLBORONIC ACID;(2-METHYLPROPYL)BORONIC ACID;2-Methylpropaneboronic acid;Isobutylboronic;RARECHEM AH PB 0258;FUB-144 fubamb 5fadb;Ixazomib Impurity 34;isobutaneboronic acid;1-ISOBUTANEBORONIC ACID;Bortezomib impurity 100
- CBNumber:
- CB9729575
- Molecular Formula:
- C4H11BO2
- Molecular Weight:
- 101.94
- MDL Number:
- MFCD00134156
- MOL File:
- 84110-40-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 108-111 °C(lit.) |
|---|---|
| Boiling point | 180.0±23.0 °C(Predicted) |
| Density | 0.910±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Acetonitrile (Slightly), DMSO, Methanol (Slightly) |
| pka | 10.49±0.43(Predicted) |
| form | Crystalline Powder or Flakes |
| color | White to cream |
| InChI | InChI=1S/C4H11BO2/c1-4(2)3-5(6)7/h4,6-7H,3H2,1-2H3 |
| InChIKey | ZAZPDOYUCVFPOI-UHFFFAOYSA-N |
| SMILES | B(CC(C)C)(O)O |
| CAS DataBase Reference | 84110-40-7(CAS DataBase Reference) |
| FDA UNII | KHX76H7JHZ |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | No | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Isobutaneboronic acid price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 346225 | (2-Methylpropyl)boronic acid ≥95.0% | 84110-40-7 | 1g | $40 | 2026-04-30 | Buy |
| Sigma-Aldrich | 346225 | (2-Methylpropyl)boronic acid ≥95.0% | 84110-40-7 | 5g | $85.5 | 2026-04-30 | Buy |
| TCI Chemical | I0597 | Isobutylboronic Acid (contains varying amounts of Anhydride) | 84110-40-7 | 5g | $74 | 2026-04-30 | Buy |
| TCI Chemical | I0597 | Isobutylboronic Acid (contains varying amounts of Anhydride) | 84110-40-7 | 25g | $296 | 2026-04-30 | Buy |
| Usbiological | 280325 | Isobutylboronic acid | 84110-40-7 | 5g | $307 | 2026-06-03 | Buy |
Isobutaneboronic acid Chemical Properties,Uses,Production
Description
Isobutaneboronic acid is also known as isobutylboronic acid. Isobutaneboronic acid has been used to synthesize potent and selective dipeptidyl boronic acid proteasome inhibitors, which are promising therapeutics to treat cancer and inflammatory diseases.1
Reference
J. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338
Chemical Properties
White to Almost white powder to crystal
Uses
suzuki reaction
Uses
2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.
Uses
(2-Methylpropyl)boronic acid can be used as:
A reactant in the preparation of 4-isobutylisoquinoline from 4-bromoisoquinoline by Suzuki-Miyaura type couple reaction.
A catalyst along with aluminum hydroxide, boric acid in the polymerization of styrene.
It can also be used as a reactant in:
Copper catalyzed cross-coupling reactions.
The synthesis of polyborylalkanes by Ir-catalyzed C-H borylation reaction.
The preparation of heterosubstituted diazaboroles and borinines.
Synthesis
In a 50 ml round-bottomed flask containing potassium 4-methoxyphenyltrifluoroborate (456 mg, 3.0 mmol) and silica gel (180 mg, 3.0 mmol), a volume of H2O (9 mL) was added rapidly under nitrogen. The reaction was stirred at room temperature until NMR indicated that the reaction was complete (about 1 h). The reaction mixture was filtered to remove silica gel and the filter cake was thoroughly rinsed with ethyl acetate to separate the aqueous and organic layers, and the aqueous layer was extracted with ethyl acetate (2 15 mL) (Table 2, electron-deficient arylboronic acid washed with brine). The combined organic layers were dried (MgSO4), filtered, concentrated, and vacuum dried overnight to provide the desired pure product in 83% yield (0.38 g, 2.49 mmol) as a white solid. The conventional operation was then continued using potassium isobutyl trifluoroborate and the reaction was completed within 1 hour. The desired pure product was obtained in 73% yield (0.24 g, 2.3 mmol) resulting in isobutylboronic acid as a white solid.
Isobutaneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AllyChem Co., Ltd. | 0411-62313318 13889470786 | info@allychem.com | China | 1021 | 65 |
| Shanghai Kangtuo Chemical Co., Ltd. | 021-69185552 13701777608 | kangtuochem@163.com | China | 4224 | 55 |
| Tianjin Xinshengjiahe Technology Development Co., Ltd. | 022-83719186 13212251377 | 18522618860@163.com | China | 82 | 55 |
| Anhui Tokind Advanced Material Co., Ltd. | 0554-2114112 18118134211 | tokind@tokinchem.com | China | 58 | 58 |
| Tianshui YiYao Chemical Co., Ltd. | 0938-0938-8493022 15379872136 | xiaoshi079@163.com | China | 2030 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
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View Lastest Price from Isobutaneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Isobutylboronic Acid
84110-40-7
|
$11.00 | 1KG | 99% | 100mt | Jinan Finer Chemical Co., Ltd | |
 |
2026-08-12 | Isobutaneboronic acid
84110-40-7
|
$253.00 | 100g | 98% | 1kg | Baoji Guokang Healthchem Co., Ltd. | |
 |
2026-03-20 | Isobutaneboronic acid
84110-40-7
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Isobutylboronic Acid
84110-40-7
- $11.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Isobutaneboronic acid
84110-40-7
- $253.00
- 98%
- Baoji Guokang Healthchem Co., Ltd.
-
- Isobutaneboronic acid
84110-40-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
