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Ethyl (ethoxymethylene)cyanoacetate

Ethyl (ethoxymethylene)cyanoacetate structure

CAS No.: 94-05-3

Chemical Name:: Ethyl (ethoxymethylene)cyanoacetate

Synonyms: ETHYL 2-CYANO-3-ETHOXYACRYLATE;ethyl (Z)-2-cyano-3-ethoxyacrylate;(E)-ethyl 2-cyano-3-ethoxyacrylate;EMCAE;Ethyl (ethoxyMethyle;2-Cyano-3-ethoxyacryL;Neratinib Impurity 52;Ethyl (ethoxymethylene);Ethyl-2-cyan-3-ethoxyacrylat;(ethoxymethylene)cyanoacetate

CBNumber:: CB9758865

Molecular Formula:: C8H11NO3

Molecular Weight:: 169.18

MDL Number:: MFCD00009136

MOL File:: 94-05-3.mol

MSDS File:: SDS

Last updated:2026-01-25 15:34:02

Product description	Number	Pack Size	Price
Ethyl 2-cyano-3-ethoxyacrylate 98%	E28005	25g	$50.73
Ethyl 2-cyano-3-ethoxyacrylate 98%	E28005	100g	$54.05
Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	E0341	25g	$22
Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	E0341	500g	$222
EthylCyano(ethoxymethylene)acetate	E907510	5g	$50
More product size

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Ethyl (ethoxymethylene)cyanoacetate Properties

Melting point	49-51 °C(lit.)
Boiling point	190-191 °C30 mm Hg(lit.)
Density	1.2435 (rough estimate)
refractive index	1.5100 (estimate)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Crystalline Mass or Crystals
color	White to yellow
Water Solubility	<0.01 g/L (20 ºC)
BRN	878814
InChI	1S/C8H11NO3/c1-3-11-6-7(5-9)8(10)12-4-2/h6H,3-4H2,1-2H3/b7-6+
InChIKey	KTMGNAIGXYODKQ-VOTSOKGWSA-N
SMILES	CCO\C=C(/C#N)C(=O)OCC
LogP	1.376 at 25℃
CAS DataBase Reference	94-05-3(CAS DataBase Reference)
FDA UNII	0F33W9H92I
NIST Chemistry Reference	2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester(94-05-3)
EPA Substance Registry System	2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester (94-05-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H315-H317-H319-H334-H335

Precautionary statements

P261-P284-P301+P310a-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T,Xn

Risk Statements

36/37/38-42/43-41-37/38-22

Safety Statements

26-37/39

RIDADR

3276

WGK Germany

Hazard Note

Toxic

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29269090

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

Ethyl (ethoxymethylene)cyanoacetate price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E28005	Ethyl 2-cyano-3-ethoxyacrylate 98%	94-05-3	25g	$50.73	2025-07-31	Buy
Sigma-Aldrich	E28005	Ethyl 2-cyano-3-ethoxyacrylate 98%	94-05-3	100g	$54.05	2025-07-31	Buy
TCI Chemical	E0341	Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	94-05-3	25g	$22	2025-07-31	Buy
TCI Chemical	E0341	Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	94-05-3	500g	$222	2025-07-31	Buy
TRC	E907510	EthylCyano(ethoxymethylene)acetate	94-05-3	5g	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
E28005	25g	$50.73	Buy
E28005	100g	$54.05	Buy
E0341	25g	$22	Buy
E0341	500g	$222	Buy
E907510	5g	$50	Buy

Ethyl (ethoxymethylene)cyanoacetate Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline solid

Uses

Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.

Synthesis

122-51-0

105-56-6

94-05-3

a) General procedure for the preparation of ethyl 4-(2-cyano-2-ethoxycarbonylvinylamino)benzoate: triethyl orthoformate (33.3 mL, 0.2 mol) was mixed with ethyl cyanoacetate (21.3 mL, 0.2 mol) in acetic acid anhydride (80 mL), and the mixture was heated for 5 hr at 150-160 °C. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give ethyl 2-cyano-3-ethoxyacrylate as a yellow solid (28.5 g, 84% yield).

References

[1] Patent: US2006/4046, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0274
[3] Arkivoc, 2017, vol. 2017, # 3, p. 73 - 86
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 591 - 599
[5] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 18

Ethyl (ethoxymethylene)cyanoacetate synthesis

Synthesis of Ethyl (ethoxymethylene)cyanoacetate from Ethanol and Ethyl 2-cyano-3-(dimethylamino)acrylate

Ethyl (ethoxymethylene)cyanoacetate Preparation Products And Raw materials

Raw materials

Ethyl cyanoacetate Triethyl orthoformate

Preparation Products

Allopurinol 4-AMINO-5-CARBOXY-2-ETHYL-MERCAPTOPYRIMIDINE Ethyl 3-amino-4-pyrazolecarboxylate 5-CARBOXYCYTOSINE 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID

ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 5-HYDROXYMETHYLCYTOSINE 1,4-Dicyanobenzene ETHYL 5-AMINO-1-METHYLPYRAZOLE-4-CARBOXYLATE PYRAZOLE-4-CARBOXYLIC ACID, 3-AMINO-1-METHYL-, ETHYL ESTER

ethyl 2-cyano-3-ethoxycrotonate 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 5-Amino-1-(2-chlorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

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Ethyl (ethoxymethylene)cyanoacetate Suppliers

Global( 330)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangxi Huihe Chemical Co., Ltd.	+86-19189228086 +8618858568638	wuzhouding@huihecrop.com	China	886	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8731	58
Wuhan Fortuna Chemical Co., Ltd	+86-027-59207850 +86-13986145403;	info@fortunachem.com	China	6011	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+1-5184799099	lbaochemicals@gmail.com	China	674	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58

Supplier	Advantage
Jiangxi Huihe Chemical Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Shanghai UCHEM Inc.	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
career henan chemical co	58

View Lastest Price from Ethyl (ethoxymethylene)cyanoacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-15	Ethyl (ethoxymethylene)cyanoacetate 94-05-3	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2026-02-13	Ethyl (ethoxymethylene)cyanoacetate 94-05-3	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-11	Ethyl cyano(ethoxymethylene)acetate 94-05-3	US $40.00-240.00 / g	25g	0.98	25kg	Shanghai UCHEM Inc.

Ethyl (ethoxymethylene)cyanoacetate
94-05-3
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

Ethyl (ethoxymethylene)cyanoacetate
94-05-3
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Ethyl cyano(ethoxymethylene)acetate
94-05-3
US $40.00-240.00 / g
0.98
Shanghai UCHEM Inc.

Ethyl (ethoxymethylene)cyanoacetate Spectrum

Ethyl (ethoxymethylene)cyanoacetate(94-05-3)MS Ethyl (ethoxymethylene)cyanoacetate(94-05-3)¹HNMR Ethyl (ethoxymethylene)cyanoacetate(94-05-3)¹³CNMR Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR1 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR2 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR3 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)Raman

94-05-3(Ethyl (ethoxymethylene)cyanoacetate)Related Search:

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acetic acid, triethoxy-, ethyl ester Ethanol Cyanoacetic acid

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Acrylic acid, 2-cyano-3-ethoxy-, ethyl ester Ethyl (2E)-2-cyano-3-ethoxy-2-propenoate Ethyl 3-ethoxy-2-cyanoacrylate Ethyl alpha-(ethoxymethylene)-alpha-cyanoacetate Ethyl cyano(ethoxymethylene)acetate 2-cyano-3-ethoxy-2-propenoicaciethylester 2-Propenoicacid,2-cyano-3-ethoxy-,ethylester 2-CYANO-3-ETHOXY-2-PROPENOIC ACID ETHYL ESTER 2-CYANO-3-ETHOXYACRYLIC ACID ETHYL ESTER ETHYL 2-CYANO-3-ETHOXYACRYLATE FOR SYNTH Ethyl 2-cyano-3-ethoxyacrylate 98% 2-(ETHOXYMETHYLENE)-2-CYANOACETIC ACID ETHYL ESTER EMCAE ETHOXY METHYLENE CYANOACETIC ACID ETHYL ESTER ETHYL 2-(ETHOXYMETHYLENE)-2-CYANOACETATE ETHYL 2-CYANO-3-ETHOXYACRYLATE ETHYL (ETHOXYMETHYLENE)CYANOACETATE Ethoxyl Methylene Cyanoacetic Ethyl Ethyl-2-cyan-3-ethoxyacrylat Ethyl (E)-2-cyano-3-ethoxyprop-2-enoate 2-Cyano-3-ethoxypropenoic acid ethyl ester 2-Ethoxymethylenecyanoacetic acid ethyl ester 3-Ethoxy-2-cyanopropenoic acid ethyl ester Cyano(ethoxymethylene)acetic acid ethyl ester Ethyl 2-ethoxymethylene-cyanoacetate Ethyl(Ethoxymethylene)cyaoacetate Ethyl 2-Cyano-3-ethoxyacrylate, 97+% Ethoxy heartland of methyl ethyl cyano acetate ethyl (Z)-2-cyano-3-ethoxyacrylate Ethyl (ethoxymethylene) (E)-ethyl 2-cyano-3-ethoxyacrylate Ethyl 2-cyano-3-ethoxyprop-2-enoate, Ethyl (ethoxymethylene)cyanoacetate Ethyl (ethoxyMethyle 2-Cyano-3-ethoxyacrylic Acid Ethyl Ester 2-(Ethoxymethylene)-2-cyanoacetic Acid Ethyl Ester Ethyl 2-Cyano-3-ethoxyacrylate 2-Cyano-3-ethoxyacryL Ethyl2-(Ethoxymethylene)-2-cyanoacetate> (ethoxymethylene)cyanoacetate Neratinib Impurity 52 TIANFU-CHEM - Ethyl (ethoxymethylene)cyanoacetate ethyl (2Z)-2-cyano-3-ethoxyprop-2-enoate 94-05-3 1994-5-3 1994-05-03 1994-05-3 C2H5OCHCCNCOOC2H5 Building Blocks Carbonyl Compounds C8 to C9 Esters Organic Building Blocks Aliphatic Compound Pharmaceutical Intermediates Building Blocks C8 to C9 Carbonyl Compounds Chemical Synthesis Esters Organic Building Blocks