ChemicalBook >> CAS DataBase List >>Ethyl (ethoxymethylene)cyanoacetate

Ethyl (ethoxymethylene)cyanoacetate

Ethyl (ethoxymethylene)cyanoacetate structure

CAS No.: 94-05-3

Chemical Name:: Ethyl (ethoxymethylene)cyanoacetate

Synonyms: ETHYL 2-CYANO-3-ETHOXYACRYLATE;ethyl (Z)-2-cyano-3-ethoxyacrylate;(E)-ethyl 2-cyano-3-ethoxyacrylate;EMCAE;Ethyl (ethoxyMethyle;2-Cyano-3-ethoxyacryL;Neratinib Impurity 52;Ethyl (ethoxymethylene);Ethyl-2-cyan-3-ethoxyacrylat;(ethoxymethylene)cyanoacetate

CBNumber:: CB9758865

Molecular Formula:: C8H11NO3

Molecular Weight:: 169.18

MDL Number:: MFCD00009136

MOL File:: 94-05-3.mol

MSDS File:: SDS

Last updated:2026-05-28 06:06:28

Request For Quotation

Ethyl (ethoxymethylene)cyanoacetate Properties

Melting point	49-51 °C(lit.)
Boiling point	190-191 °C30 mm Hg(lit.)
Density	1.2435 (rough estimate)
refractive index	1.5100 (estimate)
Flash point	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Crystalline Mass or Crystals
color	White to yellow
Water Solubility	<0.01 g/L (20 ºC)
BRN	878814
InChI	1S/C8H11NO3/c1-3-11-6-7(5-9)8(10)12-4-2/h6H,3-4H2,1-2H3/b7-6+
InChIKey	KTMGNAIGXYODKQ-VOTSOKGWSA-N
SMILES	CCO\C=C(/C#N)C(=O)OCC
LogP	1.376 at 25℃
CAS DataBase Reference	94-05-3(CAS DataBase Reference)
FDA UNII	0F33W9H92I
NIST Chemistry Reference	2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester(94-05-3)
EPA Substance Registry System	2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester (94-05-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H315-H317-H319-H334-H335

Precautionary statements

P261-P284-P301+P310a-P305+P351+P338-P405-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,T,Xn

Risk Statements

36/37/38-42/43-41-37/38-22

Safety Statements

26-37/39

RIDADR

3276

WGK Germany

Hazard Note

Toxic

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29269090

Storage Class

11 - Combustible Solids

REACH Registrations

Active

NFPA 704

	1
2		0

Ethyl (ethoxymethylene)cyanoacetate price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	E28005	Ethyl 2-cyano-3-ethoxyacrylate 98%	94-05-3	25g	$56.9	2026-04-30	Buy
Sigma-Aldrich	E28005	Ethyl 2-cyano-3-ethoxyacrylate 98%	94-05-3	100g	$60.6	2026-04-30	Buy
TCI Chemical	E0341	Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	94-05-3	25g	$22	2026-04-30	Buy
TCI Chemical	E0341	Ethyl 2-(Ethoxymethylene)-2-cyanoacetate >98.0%(GC)	94-05-3	500g	$222	2026-04-30	Buy
Usbiological	449608	Ethyl Cyano(ethoxymethylene)acetate	94-05-3	5g	$319	2026-06-03	Buy

Product number	Packaging	Price	Buy
E28005	25g	$56.9	Buy
E28005	100g	$60.6	Buy
E0341	25g	$22	Buy
E0341	500g	$222	Buy
449608	5g	$319	Buy

Ethyl (ethoxymethylene)cyanoacetate Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystalline solid

Uses

Ethyl Cyano(ethoxymethylene)acetate is an intermediate in the synthesis of anti-inflammatory agents with gastroprotective effect in rats.

Synthesis

122-51-0

105-56-6

94-05-3

a) General procedure for the preparation of ethyl 4-(2-cyano-2-ethoxycarbonylvinylamino)benzoate: triethyl orthoformate (33.3 mL, 0.2 mol) was mixed with ethyl cyanoacetate (21.3 mL, 0.2 mol) in acetic acid anhydride (80 mL), and the mixture was heated for 5 hr at 150-160 °C. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give ethyl 2-cyano-3-ethoxyacrylate as a yellow solid (28.5 g, 84% yield).

References

[1] Patent: US2006/4046, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: WO2014/145986, 2014, A1. Location in patent: Paragraph 0274
[3] Arkivoc, 2017, vol. 2017, # 3, p. 73 - 86
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 591 - 599
[5] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 18

Ethyl (ethoxymethylene)cyanoacetate synthesis

Synthesis of Ethyl (ethoxymethylene)cyanoacetate from Ethanol and Ethyl 2-cyano-3-(dimethylamino)acrylate

Ethyl (ethoxymethylene)cyanoacetate Preparation Products And Raw materials

Raw materials

Ethyl cyanoacetate Triethyl orthoformate

Preparation Products

Allopurinol 4-Amino-5-carboxy-2-ethyl-mercaptopyrimidine Ethyl 3-amino-4-pyrazolecarboxylate 5-Carboxycytosine 4-Amino-2-(methylthio)pyrimidine-5-carboxylic acid

Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate 5-Hydroxymethylcytosine 1,4-Dicyanobenzene Ethyl 5-amino-1-methylpyrazole-4-carboxylate Pyrazole-4-carboxylic acid, 3-amino-1-methyl-, ethyl ester

ethyl 2-cyano-3-ethoxycrotonate 5-Amino-4-carbethoxy-1-phenylpyrazole 5-Amino-1-(2-chlorophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

1of3

Ethyl (ethoxymethylene)cyanoacetate Suppliers

Global Suppliers ( 339)

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei zhonglong Kangsheng Fine Chemical Co., Ltd	027-027-83850178 18162590268	1984393783@qq.com	China	4740	58
NORANA GROUP	027-59209883 17386138556	service@nornachem.com	China	4874	58
Hubei DAHAO Chemical Co., Ltd.	027-027-59106191 13986034860	1400828855@qq.com	China	8682	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Hubei zhonglong Kangsheng Fine Chemical Co., Ltd	58
NORANA GROUP	58
Hubei DAHAO Chemical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Latest Price from Ethyl (ethoxymethylene)cyanoacetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Ethyl cyano(ethoxymethylene)acetate 94-05-3	$40.00-240.00	25g	0.98	25kg	Shanghai UCHEM Inc.
2026-09-11	Ethyl (ethoxymethylene)cyanoacetate 94-05-3		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-28	Ethyl (ethoxymethylene)cyanoacetate 94-05-3	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

Ethyl cyano(ethoxymethylene)acetate
94-05-3
$40.00-240.00
0.98
Shanghai UCHEM Inc.

Ethyl (ethoxymethylene)cyanoacetate
94-05-3
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Ethyl (ethoxymethylene)cyanoacetate
94-05-3
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Ethyl (ethoxymethylene)cyanoacetate Spectrum

Ethyl (ethoxymethylene)cyanoacetate(94-05-3)MS Ethyl (ethoxymethylene)cyanoacetate(94-05-3)¹HNMR Ethyl (ethoxymethylene)cyanoacetate(94-05-3)¹³CNMR Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR1 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR2 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)IR3 Ethyl (ethoxymethylene)cyanoacetate(94-05-3)Raman

94-05-3 (Ethyl (ethoxymethylene)cyanoacetate) Related Search:

Tris(trimethylsilyl)phosphate Ethyl 3-ethoxyacrylate Ethyl acrylate Ethyl cellulose Ethylbenzene

Ethyl acetate Ethyl cyanoformate acetic acid, triethoxy-, ethyl ester Ethyl N-cyanoethanimideate Ethyl methacrylate

Ethyl isocyanoacetate 1-Hydroxyethylidene-1,1-diphosphonic acid Ethanol oxyma Chloroethane

Ethyl 2-cyanoacrylate Poly(ethyl acrylate) Cyanoacetic acid

1of4

Acrylic acid, 2-cyano-3-ethoxy-, ethyl ester Ethyl (2E)-2-cyano-3-ethoxy-2-propenoate Ethyl 3-ethoxy-2-cyanoacrylate Ethyl alpha-(ethoxymethylene)-alpha-cyanoacetate Ethyl cyano(ethoxymethylene)acetate 2-cyano-3-ethoxy-2-propenoicaciethylester 2-Propenoicacid,2-cyano-3-ethoxy-,ethylester 2-CYANO-3-ETHOXY-2-PROPENOIC ACID ETHYL ESTER 2-CYANO-3-ETHOXYACRYLIC ACID ETHYL ESTER ETHYL 2-CYANO-3-ETHOXYACRYLATE FOR SYNTH Ethyl 2-cyano-3-ethoxyacrylate 98% 2-(ETHOXYMETHYLENE)-2-CYANOACETIC ACID ETHYL ESTER EMCAE ETHOXY METHYLENE CYANOACETIC ACID ETHYL ESTER ETHYL 2-(ETHOXYMETHYLENE)-2-CYANOACETATE ETHYL (ETHOXYMETHYLENE)CYANOACETATE Ethoxyl Methylene Cyanoacetic Ethyl Ethyl-2-cyan-3-ethoxyacrylat Ethyl (E)-2-cyano-3-ethoxyprop-2-enoate 2-Cyano-3-ethoxypropenoic acid ethyl ester 2-Ethoxymethylenecyanoacetic acid ethyl ester 3-Ethoxy-2-cyanopropenoic acid ethyl ester Cyano(ethoxymethylene)acetic acid ethyl ester Ethyl 2-ethoxymethylene-cyanoacetate Ethyl(Ethoxymethylene)cyaoacetate Ethyl 2-Cyano-3-ethoxyacrylate, 97+% Ethoxy heartland of methyl ethyl cyano acetate Ethyl (ethoxymethylene) Ethyl 2-cyano-3-ethoxyprop-2-enoate, Ethyl (ethoxymethylene)cyanoacetate Ethyl (ethoxyMethyle 2-Cyano-3-ethoxyacrylic Acid Ethyl Ester 2-(Ethoxymethylene)-2-cyanoacetic Acid Ethyl Ester Ethyl 2-Cyano-3-ethoxyacrylate 2-Cyano-3-ethoxyacryL Ethyl2-(Ethoxymethylene)-2-cyanoacetate> (ethoxymethylene)cyanoacetate Neratinib Impurity 52 TIANFU-CHEM - Ethyl (ethoxymethylene)cyanoacetate ethyl (2Z)-2-cyano-3-ethoxyprop-2-enoate (E)-ethyl 2-cyano-3-ethoxyacrylate ethyl (Z)-2-cyano-3-ethoxyacrylate ETHYL 2-CYANO-3-ETHOXYACRYLATE 94-05-3 1994-5-3 1994-05-03 1994-05-3 C2H5OCHCCNCOOC2H5 Building Blocks Carbonyl Compounds C8 to C9 Esters Organic Building Blocks Aliphatic Compound Pharmaceutical Intermediates Building Blocks C8 to C9 Carbonyl Compounds Chemical Synthesis Esters Organic Building Blocks