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5-Amino-4-carbethoxy-1-phenylpyrazole

5-Amino-4-carbethoxy-1-phenylpyrazole structure

CAS No.: 16078-71-0

Chemical Name:: 5-Amino-4-carbethoxy-1-phenylpyrazole

Synonyms: ETHYL 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE;AKOS 231-01;AKOS B000506;AKOS NCG-0076;BUTTPARK 19\09-73;AKOS BBS-00002940;5-AMno-4-carbethoxy-1-phenylpyrazole;5-amino-4-carboethoxy-1-phenylyrazole;3-AMINO-4-CARBETHOXY-2-PHENYLPYRAZOLE;5-Amino-4-carbethoxy-1-phenylpyrazole

CBNumber:: CB9270345

Molecular Formula:: C12H13N3O2

Molecular Weight:: 231.25

MDL Number:: MFCD00020731

MOL File:: 16078-71-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:56:20

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5-Amino-4-carbethoxy-1-phenylpyrazole Properties

Melting point	98-100 °C (lit.)
Boiling point	373.33°C (rough estimate)
Density	1.1818 (rough estimate)
refractive index	1.5290 (estimate)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	methanol: soluble25mg/mL, clear, colorless
form	powder to crystal
pka	0.55±0.10(Predicted)
color	White to Light yellow to Light orange
BRN	211079
InChI	InChI=1S/C12H13N3O2/c1-2-17-12(16)10-8-14-15(11(10)13)9-6-4-3-5-7-9/h3-8H,2,13H2,1H3
InChIKey	AYJIUOZKKTUKKD-UHFFFAOYSA-N
SMILES	N1(C2=CC=CC=C2)C(N)=C(C(OCC)=O)C=N1
CAS DataBase Reference	16078-71-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	TA5PP5LH2V
NIST Chemistry Reference	Ethyl 3-amino-2-phenylpyrazole-4-carboxylate(16078-71-0)
EPA Substance Registry System	1H-Pyrazole-4-carboxylic acid, 5-amino-1-phenyl-, ethyl ester (16078-71-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P280a-P304+P340-P405-P501a-P261-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-37/39-36/37/39

WGK Germany

RTECS

UQ6392025

HS Code

29331990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

5-Amino-4-carbethoxy-1-phenylpyrazole price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	379441	Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate 98%	16078-71-0	5g	$85.8	2023-06-20	Buy
TCI Chemical	E1258	Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC)	16078-71-0	1g	$115	2026-04-30	Buy
TCI Chemical	E1258	Ethyl 5-Amino-1-phenylpyrazole-4-carboxylate >98.0%(HPLC)	16078-71-0	5g	$461	2026-04-30	Buy
Usbiological	275610	Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported	16078-71-0	5g	$333	2026-06-03	Buy
Usbiological	275610	Ethyl 5-amino-1-phenylpyrazole-4-carboxylate Asreported	16078-71-0	10g	$475	2026-06-03	Buy

Product number	Packaging	Price	Buy
379441	5g	$85.8	Buy
E1258	1g	$115	Buy
E1258	5g	$461	Buy
275610	5g	$333	Buy
275610	10g	$475	Buy

5-Amino-4-carbethoxy-1-phenylpyrazole Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystalline flakes

Uses

Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate may be used as internal standard for the GC-MS determination of etomidate [ethyl-1-(1-phenylethyl)-1H-imidazole-5-carboxylate] in mouse brain tissue.

General Description

Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate is a heterocyclic building block.

Synthesis

100-63-0

94-05-3

16078-71-0

General procedure for the synthesis of ethyl 5-amino-1-phenylpyrazole-4-carboxylate from phenylhydrazine and ethyl ethoxymethylcyanoacetate: ethyl 2-cyano-3-ethoxyacrylate (1.5 g, 8.9 mmol, 1.0 equiv.) was dissolved in ethanol (10 mL), followed by the addition of N,N-diisopropylethylamine (0.74 mL, 9.8 mmol, 1.1 equiv.) and phenylhydrazine (0.96 mL, 9.8 mmol, 1.1 equiv.). The reaction mixture was heated to 85 °C and stirred for 12 hours. Upon completion of the reaction, the mixture was concentrated to dryness and the residue was dissolved in a minimal amount of dichloromethane and purified by silica gel column chromatography (eluent: 20-30% ethyl acetate in hexane solution) to afford ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate (2.0 g, 96% yield) as an orange solid.MS (EI) m/z: 232 [M + H]+.

References

[1] Patent: WO2016/49500, 2016, A1. Location in patent: Paragraph 00217
[2] Cell Chemical Biology, 2018,
[3] Organic Letters, 2013, vol. 15, # 19, p. 5044 - 5047
[4] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4428 - 4433
[5] Tetrahedron, 2017, vol. 73, # 40, p. 5959 - 5973

5-Amino-4-carbethoxy-1-phenylpyrazole synthesis

Synthesis of 5-Amino-4-carbethoxy-1-phenylpyrazole from Ethyl (ethoxymethylene)cyanoacetate and Phenylhydrazine

5-Amino-4-carbethoxy-1-phenylpyrazole Preparation Products And Raw materials

Raw materials

Ethanol Triethyl orthoformate Acetic acid Phenylhydrazine Ethyl cyanoacetate

ethyl 3-aMino-1-phenyl-1H-pyrazole-4-carboxylate (E)-Ethyl 2-cyano-3-ethoxyacrylate Ethyl 3-amino-4-pyrazolecarboxylate Ethyl (ethoxymethylene)cyanoacetate Iodobenzene

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Preparation Products

5-Amino-1-phenylpyrazole-4-carboxamide

5-Amino-4-carbethoxy-1-phenylpyrazole Suppliers

Global Suppliers ( 155)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Pure Chemistry Scientific Inc.	62
Adamas Reagent, Ltd.	59

View Latest Price from 5-Amino-4-carbethoxy-1-phenylpyrazole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-10	5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE 16078-71-0	$1.00	1KG	99%	200kg	Career Henan Chemical Co

5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE
16078-71-0
$1.00
99%
Career Henan Chemical Co

5-Amino-4-carbethoxy-1-phenylpyrazole Spectrum

5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE(16078-71-0)MS 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE(16078-71-0)¹HNMR 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE(16078-71-0)IR1 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE(16078-71-0)IR2 5-AMINO-4-CARBETHOXY-1-PHENYLPYRAZOLE(16078-71-0)Raman

16078-71-0 (5-Amino-4-carbethoxy-1-phenylpyrazole) Related Search:

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1H-Pyrazole-4-carboxylic acid, 5-amino-1-phenyl-, ethyl ester 5-amino-1-phenyl-1h-pyrazole-4-carboxylicaciethylester ETHYL 5-AMINO-1-PHENYL-4-PYRAZOLECARBOXYLATE ETHYL 5-AMINO-1-PHENYLPYRAZOLE-4-CARBOXYLATE BUTTPARK 19\09-73 5-AMINO-1-PHENYL-4-PYRAZOLECARBOXYLIC ACID ETHYL ESTER 5-amino-1-phenylpyrazole-4-carboxylic acid ethyl ester 5-amino-4-carboethoxy-1-phenylyrazole 5-amino-4-ethoxycarbonyl-1-phenylpyrazole 5-Amino-4-carbethoxy-1-phenylpyrazole,98% 5-aMino-1-phenyl-4-pyrazolecarboxylate 5-AMno-4-carbethoxy-1-phenylpyrazole Ethyl 5-amino-1-phenyl-4-pyrazolecarboxylate 98% AKOS B000506 AKOS 231-01 AKOS NCG-0076 AKOS BBS-00002940 3-AMINO-4-CARBETHOXY-2-PHENYLPYRAZOLE 5-AMINO-4-CARBOETHOXY-1-PHENYLPYRAZOLE 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER ETHYL 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 5-Amino-4-carbethoxy-1-phenylpyrazole 16078-71-0 AMINO Pyrazoles Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines Heterocyclic Compounds Building Blocks Heterocyclic Building Blocks Pyrazoles