5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE
- CAS No.
- 5334-43-0
- Chemical Name:
- 5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE
- Synonyms
- 5-AMINO-1-PHENYL-1H-PYRAZOLE-4-CARBONITRILE;MB-3670;AKOS B018556;AKOS UB-20252;BUTTPARK 51\09-65;AKOS BBS-00000722;TIMTEC-BB SBB005515;ART-CHEM-BB B018556;1-PHENYL-4-CYANO-5-AMINOPYRAZOLE;5-AMINO-4-CYANO-1-PHENYLPYRAZOLE
- CBNumber:
- CB9777187
- Molecular Formula:
- C10H8N4
- Molecular Weight:
- 184.2
- MDL Number:
- MFCD00020730
- MOL File:
- 5334-43-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Amino-1-phenylpyrazole-4-carbonitrile 96% | 389595 | 1g | $38.9 |
| 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 258489 | 1g | $350 |
| 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 258489 | 2g | $483 |
| 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 258489 | 5g | $652 |
| 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 258489 | 10g | $881 |
| More product size | |||
| Melting point | 132-137 °C (lit.) |
|---|---|
| Boiling point | 402.0±30.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | -1.12±0.10(Predicted) |
| form | Solid |
| color | Pale Yellow to Dark Yellow |
| BRN | 161503 |
| Stability | Stable |
| InChI | 1S/C10H8N4/c11-6-8-7-13-14(10(8)12)9-4-2-1-3-5-9/h1-5,7H,12H2 |
| InChIKey | MAKQREKUUHPPIS-UHFFFAOYSA-N |
| SMILES | Nc1c(cnn1-c2ccccc2)C#N |
| CAS DataBase Reference | 5334-43-0(CAS DataBase Reference) |
| FDA UNII | 65KX32U6WT |
| NIST Chemistry Reference | 5-Amino-4-cyano-1-phenyl pyrazole(5334-43-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 389595 | 5-Amino-1-phenylpyrazole-4-carbonitrile 96% | 5334-43-0 | 1g | $38.9 | 2023-06-20 | Buy |
| Usbiological | 258489 | 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 5334-43-0 | 1g | $350 | 2026-06-03 | Buy |
| Usbiological | 258489 | 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 5334-43-0 | 2g | $483 | 2026-06-03 | Buy |
| Usbiological | 258489 | 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 5334-43-0 | 5g | $652 | 2026-06-03 | Buy |
| Usbiological | 258489 | 5-Amino-1-phenylpyrazolo-4-carbonitrile Asreported | 5334-43-0 | 10g | $881 | 2026-06-03 | Buy |
5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE Chemical Properties,Uses,Production
Chemical Properties
Off-White Powder
Uses
Shown to have chemiluminescence activity, antifilarial activity and to possess adenosine receptor affinity.
Definition
ChEBI: 5-amino-1-phenyl-1H-pyrazole-4-carbonitrile is a member of pyrazoles and a ring assembly.
Synthesis
100-63-0
123-06-8
5334-43-0
3.2 Synthesis of 5-amino-4-cyano-1-phenyl-1H-pyrazole (3a) Phenylhydrazine (2d) (0.45 mL, 4.2 mmol) was dissolved in ethanol (4 mL) with ethoxymethylene malononitrile (1b) (0.51 g, 4.2 mmol). Microwave irradiation was carried out using a CEM Discover microwave synthesizer at 120 °C for 45 min in a sealed pressure rated Pyrex tube (10 mL) with an initial power setting of 100 W. The reaction was carried out in a compressed air chamber with the microwave irradiated at 120 °C for 1 min. Upon completion of the reaction, the solvent was cooled in a stream of compressed air and subsequently removed by decompression distillation. The product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (5:1 v/v) as eluent to afford 1-phenyl-4-cyano-5-aminopyrazole (0.738 g, 95% yield) as a light brown solid with a melting point of 137-139 °C (literature value: 137 °C). High-resolution mass spectrum (measured value: 185.0827, C10H9N4 [MH]+ calculated value: 185.0822); Fourier transform infrared spectra (KBr, cm1) νmax: 3302 (NH), 3240 (NH), 2230 (CN), 1577, 1530, 1368; 1H NMR (400 MHz, CDCl3) δ: 7.58 (1H, s, H-3), 7.49-7.37 (5H, m, Ph), 4.52 (2H, br s, disappears after exchange of D2O, NH2); 13C NMR (100 MHz, CDCl3) δ: 141.9 (CH), 135.0 (C), 129.3 (CH), 125.5 (CH), 124.1 ( CH), 121.3 (CH), 115.6 (C), 86.2 (C); low resolution mass spectra (APcI) m/z (relative intensity): 226 ([M + MeCNH]+, 100), 185 ([MH]+, 64).
References
[1] Tetrahedron, 2013, vol. 69, # 39, p. 8429 - 8438
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 3, p. 591 - 599
[3] European Journal of Organic Chemistry, 2018, vol. 2018, # 13, p. 1514 - 1524
[4] Synthetic Communications, 2011, vol. 41, # 10, p. 1500 - 1507
[5] Heterocyclic Communications, 2005, vol. 11, # 5, p. 385 - 388
5-AMINO-1-PHENYLPYRAZOLE-4-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49962 | 58 |
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