3'-Bromo-2'-Fluoroacetophenone
- CAS No.
- 161957-61-5
- Chemical Name:
- 3'-Bromo-2'-Fluoroacetophenone
- Synonyms
- 1-(3-Bromo-2-fluorophenyl)ethan-1-one;153471;1-(3-Bromo-2-fL;3-Bromo-2-fluorobenzophenone;3-bormo-2-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3'-Bromo-2'-fluoroacetophenone;3-Bromo-2-fluoroacetophenone,96%;3'-Bromo-2'-fluoroacetophenone 95%;1-(3-Bromo-2-fluoro-phenyl)-ethanone
- CBNumber:
- CB9950175
- Molecular Formula:
- C8H6BrFO
- Molecular Weight:
- 217.04
- MDL Number:
- MFCD09264507
- MOL File:
- 161957-61-5.mol
- MSDS File:
- SDS
| Boiling point | 252.4±25.0 °C(Predicted) |
|---|---|
| Density | 1.535±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | Solid |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C8H6BrFO/c1-5(11)6-3-2-4-7(9)8(6)10/h2-4H,1H3 |
| InChIKey | GSLFYQYBXIVNLS-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=CC(Br)=C1F)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2914790090 | |||||||||
| NFPA 704 |
|
3'-Bromo-2'-Fluoroacetophenone price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC48297 | 3'-Bromo-2'-fluoroacetophenone 98% | 161957-61-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC48297 | 3'-Bromo-2'-fluoroacetophenone 98% | 161957-61-5 | 5g | $54 | 2026-06-04 | Buy |
| Apolloscientific | PC48297 | 3'-Bromo-2'-fluoroacetophenone 98% | 161957-61-5 | 10g | $104 | 2026-06-04 | Buy |
| Activate Scientific | AS15282 | 1-(3-Bromo-2-fluoro-phenyl)-ethanone 98% | 161957-61-5 | 1g | $34 | 2026-06-04 | Buy |
| Activate Scientific | AS15282 | 1-(3-Bromo-2-fluoro-phenyl)-ethanone 98% | 161957-61-5 | 5g | $123 | 2026-06-04 | Buy |
3'-Bromo-2'-Fluoroacetophenone Chemical Properties, Uses, Production
Synthesis Reference(s)
Tetrahedron Letters, 36, p. 881, 1995 DOI: 10.1016/0040-4039(94)02385-O
Synthesis
680610-73-5
75-16-1
161957-61-5
General procedure for the synthesis of 3-bromo-2-fluoroacetophenone from N-methoxy-N-methyl-3-bromo-2-fluorobenzamide and methylmagnesium bromide: 1. methylmagnesium bromide (3M in ether, 21mL) was slowly added to a solution of tetrahydrofuran (100mL) containing 3-bromo-2-fluoro-N-methoxy-N-methylbenzamide (10.89g) at -78°C. 2. The reaction mixture was gradually warmed to room temperature and stirred continuously for 16 hours. 3. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched by slow addition of 2 M HCl solution up to pH=1 . 4. The solvent was removed by rotary evaporator and the product was subsequently extracted with ethyl acetate (3 x 100 mL). 5. The organic layers were combined, dried over anhydrous sodium sulfate and the solvent was again removed by rotary evaporator to give a light brown solid product. 6. The resulting solid was dissolved in dichloromethane (200 mL) and washed with saturated aqueous NaHCO3 (200 mL). 7. The dichloromethane layer was separated, dried with anhydrous sodium sulfate, and finally the solvent was removed by rotary evaporator to give 1-(3-bromo-2-fluorophenyl)-acetophenone as a yellow oil (8.8 g, 97% yield). 1H NMR (CDCl3) data: δ 2.67 (3H, d, ArCOCH3), 7.11 (1H, t, Ar), 7.69-7.81 (2H, m, Ar).
References
[1] Patent: US2009/209529, 2009, A1. Location in patent: Page/Page column 34
[2] Patent: US2008/76771, 2008, A1. Location in patent: Page/Page column 18
3'-Bromo-2'-Fluoroacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Bankchem Pharmatech Co.,Ltd. | 010-80236392 17600588818 | bankchem@163.com | China | 247 | 58 |
| Hebei Boxin Biotechnology Co. , Ltd. | 19131160546 | 2681315246@qq.com | China | 13193 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
View Latest Price from 3'-Bromo-2'-Fluoroacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 3'-Bromo-2'-Fluoroacetophenone
161957-61-5
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2019-12-23 | 3'-Bromo-2'-Fluoroacetophenone
161957-61-5
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3'-Bromo-2'-Fluoroacetophenone
161957-61-5
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3'-Bromo-2'-Fluoroacetophenone
161957-61-5
- $1.00
- 99%
- Career Henan Chemical Co
