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2'-BROMO-5'-FLUOROACETOPHENONE

2'-BROMO-5'-FLUOROACETOPHENONE structure

CAS No.: 1006-33-3

Chemical Name:: 2'-BROMO-5'-FLUOROACETOPHENONE

Synonyms: 2'-Bromo-5'-fluoroacetophenone;2'-Bromo-5'-fluoroacetophenone;13C7]-2',4'-Dichloroacetophenone;Acetophenone, 2'-bromo-5'-fluoro-;2'-Bromo-5'-fluoroacetophenone,98%;1-(2-bromo-5-fluorophenyl)ethanone;2'-Bromo-5'-fluoroacetophenone, 99%;Ethanone,1-(2-bromo-5-fluorophenyl)-;1-(2-Bromo-5-fluorophenyl)ethan-1-one;"2-Bromo-5-fluoroacetophenone 13C2, D3"

CBNumber:: CB7318797

Molecular Formula:: C8H6BrFO

Molecular Weight:: 217.04

MDL Number:: MFCD07780635

MOL File:: 1006-33-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:40

Product description	Number	Pack Size	Price
2''-Bromo-5''-fluoroacetophenone	B684870	25g	$250
2'-Bromo-5'-fluoroacetophenone	FB44577	2g	$65
2'-Bromo-5'-fluoroacetophenone	2617-B-37	5G	$199
2'-Bromo-5'-fluoroacetophenone	PC32800	10g	$145
2'-Bromo-5'-fluoroacetophenone	FB44577	10g	$165
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2'-BROMO-5'-FLUOROACETOPHENONE Properties

Boiling point	144℃/18mm
Density	1.535±0.06 g/cm3(Predicted)
refractive index	1.5525
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in methanol.
form	liquid
color	Clear, pale lemon/lime

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2914790090

NFPA 704

	1
2		0

2'-BROMO-5'-FLUOROACETOPHENONE price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B684870	2''-Bromo-5''-fluoroacetophenone	1006-33-3	25g	$250	2021-12-16	Buy
Biosynth Carbosynth	FB44577	2'-Bromo-5'-fluoroacetophenone	1006-33-3	2g	$65	2021-12-16	Buy
SynQuest Laboratories	2617-B-37	2'-Bromo-5'-fluoroacetophenone	1006-33-3	5G	$199	2021-12-16	Buy
Apolloscientific	PC32800	2'-Bromo-5'-fluoroacetophenone	1006-33-3	10g	$145	2021-12-16	Buy
Biosynth Carbosynth	FB44577	2'-Bromo-5'-fluoroacetophenone	1006-33-3	10g	$165	2021-12-16	Buy

Product number	Packaging	Price	Buy
B684870	25g	$250	Buy
FB44577	2g	$65	Buy
2617-B-37	5G	$199	Buy
PC32800	10g	$145	Buy
FB44577	10g	$165	Buy

2'-BROMO-5'-FLUOROACETOPHENONE Chemical Properties,Uses,Production

Uses

2'-Bromo-5'-fluoroacetophenone is used in the synthesis of oxabicyclic compounds. It is also used in the enantioselective synthesis of chiral 3-aryl-1-indanone molecules.

Synthesis

906673-56-1

1006-33-3

General procedure for the synthesis of 2-bromo-5-fluoroacetophenone from 1-(2-bromo-5-fluorophenyl)ethanol: 1. Preparation of 1-(2-bromo-5-fluorophenyl)ethanone Trichloroisocyanuric acid (59.5 g, 0.256 mol, 1.05 eq.) was added to a solution of 1-(2-bromo-5-fluorophenyl)ethanol (53.4 g, 0.2438 mol) in dichloromethane (500 mL) at 0-20 °C. To the resulting suspension was added TEMPO (2,2,6,6-tetramethylpiperidine 1-yloxy; 188 mg, 1.20 mmol, 0.5 mol%). The reaction mixture was stirred at ice bath temperature until the oxidation was complete (HPLC monitoring, about 4.5 hours). The reaction mixture was diluted with methyl tert-butyl ether (MTBE, ca. 1300 mL), sequentially with 1N NaOH (2 × 250 mL), 1N HCl containing potassium iodide (for the removal of TEMPO; 8 g of KI in 1000 mL of 1N HCl; 2 × 250 mL), 1N NaHCO3 containing sodium thiosulfate (for the removal of I2; 15 g Na2S2O3 in 1000 mL of 1N NaHCO3), 1N HCl containing potassium iodide (1 × 200 mL), 1N NaHCO3 containing sodium thiosulfate (2 × 200 mL), and brine (150 mL) washed. After drying (anhydrous MgSO4), the solvent was removed under reduced pressure to give 1-(2-bromo-5-fluorophenyl)ethanone as a light amber liquid (52.96 g, about 97% yield) with 98% purity by HPLC, which can be used in the next reaction without further purification. 1H-NMR (300MHz, CDCl3) δ 7.59 (dd, J=8.7,4.9Hz, 1H), 7.19 (dd, J=8.5,3.0Hz, 1H), 7.04 (ddd, J=9.1,7.8,3.0Hz, 1H), 2.64 (s, 3H).

References

[1] Patent: WO2010/111418, 2010, A2. Location in patent: Page/Page column 99
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7836 - 7848
[3] Journal of Organic Chemistry, 2017, vol. 82, # 21, p. 11585 - 11593
[4] Organic Letters, 2012, vol. 14, # 12, p. 3230 - 3232
[5] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16748 - 16751

2'-BROMO-5'-FLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

1-(2-bromo-5-fluorophenyl)ethanol Methylmagnesium Bromide 2-Bromo-5-fluorobenzonitrile Trichloroisocyanuric acid TEMPO

Dichloromethane

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Preparation Products

2'-BROMO-5'-FLUOROACETOPHENONE Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Synbest Biotech(Hangzhou) Co., Ltd	86-571-88737065	sales@synbestech.com	CHINA	170	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Synbest Biotech(Hangzhou) Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58

View Lastest Price from 2'-BROMO-5'-FLUOROACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	2'-BROMO-5'-FLUOROACETOPHENONE 1006-33-3	US $0.00-0.00 / KG	1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2021-07-13	2"-BROMO-5"-FLUOROACETOPHENONE 1006-33-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	2"-BROMO-5"-FLUOROACETOPHENONE 1006-33-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2'-BROMO-5'-FLUOROACETOPHENONE
1006-33-3
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

2"-BROMO-5"-FLUOROACETOPHENONE
1006-33-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2"-BROMO-5"-FLUOROACETOPHENONE
1006-33-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2'-BROMO-5'-FLUOROACETOPHENONE Spectrum

2'-BROMO-5'-FLUOROACETOPHENONE(1006-33-3)¹HNMR

1006-33-3(2'-BROMO-5'-FLUOROACETOPHENONE)Related Search:

3'-Bromo-4'-fluoroacetophenone97%,3'-BROMO-4'-FLUOROACETOPHENONE,3-BROMO-4-FLUOROACETOPHENONE,3- BROMO-4-FLUOROACETOPHENONE 98+% 2-Bromo-2',4'-difluoroacetophenone 4'-BROMO-3'-NITROACETOPHENONE 3,5-DIFLUOROPHENACYL BROMIDE 4'-Fluoro-3'-nitroacetophenone

3'-Bromo-2'-Fluoroacetophenone 2'-Bromo-4'-fluoroacetophenone97%,2'-Bromo-4'-fluoroacetophenone 97% 2-Bromo-4'-fluoroacetophenone 2-BROMO-2'-FLUOROACETOPHENONE 2-BROMO-3'-FLUOROACETOPHENONE,ALPHA-BROMO-3-FLUOROACETOPHENONE

ALPHA,ALPHA-DIBROMO-4-FLUOROACETOPHENONE 1-(4-Bromo-2-fluorophenyl)ethanone 2'-BROMO-5'-FLUOROACETOPHENONE 2-Bromo-5-fluorobenzaldehyde 3-(2'-BROMO-5'-FLUOROPHENYL)-3-OXOPROPANENITRILE

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1-(2-bromo-5-fluorophenyl)ethanone 1-(2-Bromo-5-fluorophenyl)ethan-1-one Ethanone,1-(2-bromo-5-fluorophenyl)- Acetophenone, 2'-bromo-5'-fluoro- 2'-Bromo-5'-fluoroacetophenone,98% "2-Bromo-5-fluoroacetophenone 13C2, D3" 2'-Bromo-5'-fluoroacetophenone 13C7]-2',4'-Dichloroacetophenone 2'-Bromo-5'-fluoroacetophenone, 99% 2'-Bromo-5'-fluoroacetophenone 1006-33-3 Adehydes, Acetals & Ketones Bromine Compounds Fluorine Compounds