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2'-Bromo-5'-fluoroacetophenone

2'-Bromo-5'-fluoroacetophenone Structure
2'-Bromo-5'-fluoroacetophenone structure
CAS No.
1006-33-3
Chemical Name:
2'-Bromo-5'-fluoroacetophenone
Synonyms
2'-Bromo-5'-fluoroacetophenone;2'-Bromo-5'-fluoroacetophenone;13C7]-2',4'-Dichloroacetophenone;Acetophenone, 2'-bromo-5'-fluoro-;2'-Bromo-5'-fluoroacetophenone,98%;1-(2-bromo-5-fluorophenyl)ethanone;2'-Bromo-5'-fluoroacetophenone, 99%;Ethanone,1-(2-bromo-5-fluorophenyl)-;1-(2-Bromo-5-fluorophenyl)ethan-1-one;"2-Bromo-5-fluoroacetophenone 13C2, D3"
CBNumber:
CB7318797
Molecular Formula:
C8H6BrFO
Molecular Weight:
217.04
MDL Number:
MFCD07780635
MOL File:
1006-33-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:55
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2'-Bromo-5'-fluoroacetophenone Properties

Boiling point 144℃/18mm
Density 1.535±0.06 g/cm3(Predicted)
refractive index 1.5525
storage temp. Sealed in dry,Room Temperature
solubility Soluble in methanol.
form liquid
color Clear, pale lemon/lime

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2914790090
NFPA 704
1
2 0

2'-Bromo-5'-fluoroacetophenone price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC32800 2'-Bromo-5'-fluoroacetophenone ≥95% 1006-33-3 1g $21 2026-06-04 Buy
Apolloscientific PC32800 2'-Bromo-5'-fluoroacetophenone ≥95% 1006-33-3 5g $28 2026-06-04 Buy
Apolloscientific PC32800 2'-Bromo-5'-fluoroacetophenone ≥95% 1006-33-3 10g $35 2026-06-04 Buy
Activate Scientific AS41649 2'-Bromo-5'-fluoroacetophenone 98% 1006-33-3 5g $28 2026-06-04 Buy
Activate Scientific AS41649 2'-Bromo-5'-fluoroacetophenone 98% 1006-33-3 25g $98 2026-06-04 Buy
Product number Packaging Price Buy
PC32800 1g $21 Buy
PC32800 5g $28 Buy
PC32800 10g $35 Buy
AS41649 5g $28 Buy
AS41649 25g $98 Buy

2'-Bromo-5'-fluoroacetophenone Chemical Properties,Uses,Production

Uses

2'-Bromo-5'-fluoroacetophenone is used in the synthesis of oxabicyclic compounds. It is also used in the enantioselective synthesis of chiral 3-aryl-1-indanone molecules.

Synthesis

1-(2-bromo-5-fluorophenyl)ethanol

906673-56-1

2'-BROMO-5'-FLUOROACETOPHENONE

1006-33-3

General procedure for the synthesis of 2-bromo-5-fluoroacetophenone from 1-(2-bromo-5-fluorophenyl)ethanol: 1. Preparation of 1-(2-bromo-5-fluorophenyl)ethanone Trichloroisocyanuric acid (59.5 g, 0.256 mol, 1.05 eq.) was added to a solution of 1-(2-bromo-5-fluorophenyl)ethanol (53.4 g, 0.2438 mol) in dichloromethane (500 mL) at 0-20 °C. To the resulting suspension was added TEMPO (2,2,6,6-tetramethylpiperidine 1-yloxy; 188 mg, 1.20 mmol, 0.5 mol%). The reaction mixture was stirred at ice bath temperature until the oxidation was complete (HPLC monitoring, about 4.5 hours). The reaction mixture was diluted with methyl tert-butyl ether (MTBE, ca. 1300 mL), sequentially with 1N NaOH (2 × 250 mL), 1N HCl containing potassium iodide (for the removal of TEMPO; 8 g of KI in 1000 mL of 1N HCl; 2 × 250 mL), 1N NaHCO3 containing sodium thiosulfate (for the removal of I2; 15 g Na2S2O3 in 1000 mL of 1N NaHCO3), 1N HCl containing potassium iodide (1 × 200 mL), 1N NaHCO3 containing sodium thiosulfate (2 × 200 mL), and brine (150 mL) washed. After drying (anhydrous MgSO4), the solvent was removed under reduced pressure to give 1-(2-bromo-5-fluorophenyl)ethanone as a light amber liquid (52.96 g, about 97% yield) with 98% purity by HPLC, which can be used in the next reaction without further purification. 1H-NMR (300MHz, CDCl3) δ 7.59 (dd, J=8.7,4.9Hz, 1H), 7.19 (dd, J=8.5,3.0Hz, 1H), 7.04 (ddd, J=9.1,7.8,3.0Hz, 1H), 2.64 (s, 3H).

References

[1] Patent: WO2010/111418, 2010, A2. Location in patent: Page/Page column 99
[2] Organic and Biomolecular Chemistry, 2011, vol. 9, # 22, p. 7836 - 7848
[3] Journal of Organic Chemistry, 2017, vol. 82, # 21, p. 11585 - 11593
[4] Organic Letters, 2012, vol. 14, # 12, p. 3230 - 3232
[5] Journal of the American Chemical Society, 2014, vol. 136, # 48, p. 16748 - 16751

2'-Bromo-5'-fluoroacetophenone Preparation Products And Raw materials

Raw materials

1-(2-bromo-5-fluorophenyl)ethanol Methylmagnesium Bromide 2-Bromo-5-fluorobenzonitrile Trichloroisocyanuric acid TEMPO
Dichloromethane

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Preparation Products

2'-Bromo-5'-fluoroacetophenone Suppliers

Global( 180)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
ShangHai DEMO Chemical Co.,Ltd 57
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Lastest Price from 2'-Bromo-5'-fluoroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2'-BROMO-5'-FLUOROACETOPHENONE pictures 2025-12-24 2'-BROMO-5'-FLUOROACETOPHENONE
1006-33-3
 1KG 99.0% 1000KG Shaanxi Dideu Medichem Co. Ltd
2 2021-07-13 2"-BROMO-5"-FLUOROACETOPHENONE
1006-33-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
2 2021-07-10 2"-BROMO-5"-FLUOROACETOPHENONE
1006-33-3
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2'-Bromo-5'-fluoroacetophenone Spectrum

2'-BROMO-5'-FLUOROACETOPHENONE(1006-33-3)1HNMR

1006-33-3(2'-Bromo-5'-fluoroacetophenone)Related Search:

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1-(2-bromo-5-fluorophenyl)ethanone 1-(2-Bromo-5-fluorophenyl)ethan-1-one Ethanone,1-(2-bromo-5-fluorophenyl)- Acetophenone, 2'-bromo-5'-fluoro- 2'-Bromo-5'-fluoroacetophenone,98% "2-Bromo-5-fluoroacetophenone 13C2, D3" 2'-Bromo-5'-fluoroacetophenone 13C7]-2',4'-Dichloroacetophenone 2'-Bromo-5'-fluoroacetophenone, 99% 2'-Bromo-5'-fluoroacetophenone 1006-33-3 Adehydes, Acetals & Ketones Bromine Compounds Fluorine Compounds