- 5-Ammonionicotinate
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- $20.00
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2022-02-25
- CAS:24242-19-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10kg
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| | 5-Aminonicotinic acid Basic information |
| | 5-Aminonicotinic acid Chemical Properties |
| Melting point | 293 °C | | Boiling point | 253.51°C (rough estimate) | | density | 1.3471 (rough estimate) | | refractive index | 1.5100 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.36±0.10(Predicted) | | form | Crystalline Powder | | color | Golden-brown | | BRN | 115848 | | InChI | InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10) | | InChIKey | BYIORJAACCWFPU-UHFFFAOYSA-N | | SMILES | C1=NC=C(N)C=C1C(O)=O | | CAS DataBase Reference | 24242-19-1(CAS DataBase Reference) |
| Hazard Codes | Xn,Xi | | Risk Statements | 36/37/38-20/21/22-22 | | Safety Statements | 36/37/39-26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Provider | Language |
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ACROS
| English |
| | 5-Aminonicotinic acid Usage And Synthesis |
| Chemical Properties | Off-white Cryst | | Uses | 5-Aminonicotinic acid is used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents. | | Definition | ChEBI: 5-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 5 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a nicotinic acid. | | Application | 5-aminonicotinic acid is an aminonicotinic acid, it is mainly used as a biochemical reagent and pharmaceutical chemical intermediate.
| | Hazard | 5-Aminonicotinic acid has acute oral toxicity and acute dermal toxicity, it causes skin irritation and serious eye irritation.
| | Synthesis | The general procedure for the synthesis of 5-aminonicotinic acid from 5-bromonicotinic acid was as follows: 5-bromo-3-pyridinecarboxylic acid (25 g, 0.124 mol) was mixed with ammonia (67.32 mL) and copper sulfate pentahydrate (8.41 g) was added. The reaction mixture was transferred to an autoclave, heated to 120 °C and kept for 16 hours. The reaction process was monitored by thin layer chromatography (TLC) using ninhydrin as a color developer. Upon completion of the reaction, the reaction mixture was washed with saturated sodium sulfide solution to remove copper ions, followed by adjusting the pH to 4-5 with concentrated hydrochloric acid.The acidified mixture was cooled to precipitate solids. The solid product was collected by filtration and dried to give 5-aminonicotinic acid (12.9 g, 74% yield). | | References | [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[2] Patent: WO2004/35545, 2004, A2. Location in patent: Page 46
[3] Patent: WO2003/101959, 2003, A1. Location in patent: Page 50-51
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981, vol. 35, # 4, p. 289 - 294
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 2381,2383 |
| | 5-Aminonicotinic acid Preparation Products And Raw materials |
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