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- 3-Bromoquinoline
-
- $11.00
-
2026-10-13
- CAS:5332-24-1
- Min. Order: 25g
- Purity: 0.98
- Supply Ability: 25kg
- 3-Bromoquinoline
-
- $1.10
-
2026-08-20
- CAS:5332-24-1
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 3-Bromoquinoline
-
-
2025-04-04
- CAS:5332-24-1
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1Ton
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| | 3-Bromoquinoline Chemical Properties |
| Melting point | 13-15 °C (lit.) | | Boiling point | 274-276 °C (lit.) | | density | 1.533 g/mL at 25 °C (lit.) | | vapor pressure | 0.196Pa at 25℃ | | refractive index | n20/D 1.664(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 2.69(at 25℃) | | form | Liquid | | color | Clear colorless to yellow | | Water Solubility | 103mg/L at 25℃ | | BRN | 112939 | | InChI | 1S/C9H6BrN/c10-8-5-7-3-1-2-4-9(7)11-6-8/h1-6H | | InChIKey | ZGIKWINFUGEQEO-UHFFFAOYSA-N | | SMILES | Brc1cnc2ccccc2c1 | | LogP | 3.03 | | CAS DataBase Reference | 5332-24-1(CAS DataBase Reference) | | NIST Chemistry Reference | Quinoline, 3-bromo-(5332-24-1) | | EPA Substance Registry System | Quinoline, 3-bromo- (5332-24-1) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | UN2810 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 29334900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | 3-Bromoquinoline Usage And Synthesis |
| Preparation | 3-Bromoquinoline reacts with mixed acids to form 3-bromo-5-nitroquinoline, which is then oxidized to 5-bromo-2,3-pyridinedicarboxylic acid upon heating with potassium permanganate. 6-Bromoquinoline reacts with nitric acid upon heating to form 6-bromo-8-nitroquinoline, which is then oxidized to 2,3-pyridinedicarboxylic acid upon reaction with potassium permanganate. 2-Bromoquinoline is prepared by reacting 2-hydroxyquinoline with phosphorus pentabromide. 3-Bromoquinoline is prepared by heating quinoline perbromide at 180°C. 4-Bromoquinoline is prepared by heating 4-hydroxyquinoline with phosphorus pentabromide, or by diazotizing 4-aminoquinoline. 5-Bromoquinoline is prepared by heating m-bromoaniline, glycerol, m-bromonitrobenzene, and concentrated sulfuric acid, or by diazotizing 5-aminoquinoline. 6-Bromoquinoline is prepared by heating p-bromoaniline with glycerol, concentrated sulfuric acid, and p-bromonitrobenzene. 7-Bromoquinoline is prepared by diazotization of 7-aminoquinoline. 8-Bromoquinoline is prepared by heating o-bromoaniline, glycerol, concentrated sulfuric acid, and o-bromonitrobenzene. Uses: As a reagent in organic synthesis. | | Bromoquinoline | There are seven position isomers with the main properties are as follows:
Name
Melting point(℃)
Boiling point(℃)
Solubility
2-bromoquinoline
48～49
It is soluble in diethyl ether, chloroform and benzene
3-bromoquinoline
12～15
274～276,
95(66.66Pa)
4-bromoquinoline
29～30
270(decomposition)
Easily soluble in dilute acid
5-bromoquinoline
52 (needle crystal)
280
7-bromoquinoline
52 (needle crystal)
290
8-bromoquinoline
80
165～166
(2399.79Pa)
| | Application and synthesis method | 3-Bromoquinoline can have action with mixed acid to generate 3-bromo-5-nitroquinoline, followed by heating with potassium permanganate to be oxidized to 5-bromo-2, 3-pyridine dicarboxylic acid.
6-bromo-quinoline can be heated together nitric acid to generate 6-bromo-8-nitro-quinoline, followed by reaction with potassium permanganate to be oxidized into 2, 3-pyridinedicarboxylic acid.
2-bromo-quinoline can be manufactured through the reaction between 2-hydroxyquinoline and phosphorus pentabromide
3-bromo-quinoline can be obtained through heating the quinoline perbromide at 180 ° C.
4-bromoquinoline can be obtained through either the heating reaction between 4-hydroxyquinoline and phosphorus pentabromide or by the diazotization reaction of 4-aminoquinoline.
5-bromo-quinoline can be obtained from the heating reaction between m-bromo aniline, glycerol, m-bromonitrobenzene and concentrated sulfuric acid, or through the diazotization reaction of 5-amino-quinoline.
6-bromo-quinoline can be obtained through the heating reaction between p-bromoaniline, glycerol, concentrated sulfuric acid and p-bromo-nitrobenzene.
7-bromoquinoline can be obtained through the diazotization of 7-aminoquinoline.
8-bromo-quinoline can be obtained through the heating of o-bromo aniline, glycerol, concentrated sulfuric acid and o-bromo-nitrobenzene in the heating system.
Purposes: as organic synthesis reagents. | | Uses | For pharmaceuticals
Medicine, pesticide intermediates | | Chemical Properties | colorless to light yellow liquid | | Uses | 3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 27, p. 1318, 1962 DOI: 10.1021/jo01051a047 | | General Description | 3-Bromoquinoline undergoes bromine-magnesium exchange reaction with lithium tributylmagnesate in toluene at -10°C, which is quenched by various electrophiles to yield functionalized quinolines. | | Flammability and Explosibility | Not classified | | References | [1] Patent: US3956301, 1976, A
[2] Patent: US5266700, 1993, A |
| | 3-Bromoquinoline Preparation Products And Raw materials |
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